期刊
NATURE NEUROSCIENCE
卷 14, 期 4, 页码 414-416出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2763
关键词
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资金
- Swiss National Science Foundation
- Systems X initiative of the Swiss Confederation
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hyperpolarizing current injections further strengthened synapses after cocaine treatment. Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts the rules for activity-dependent plasticity, eventually leading to addictive behavior.
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