期刊
NATURE NEUROSCIENCE
卷 13, 期 11, 页码 1348-1350出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2657
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资金
- Canadian Institutes for Health Research [MOP-86643, MT-13657]
- Canada Research Chair
- Ontario Graduate Scholarship
- National Science Foundation [DMS-0817703]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0817703] Funding Source: National Science Foundation
Presynaptic terminals favor intermediate-conductance Ca(V)2.2 (N type) over high-conductance Ca(V)1 (L type) channels for single-channel, Ca2+ nanodomain-triggered synaptic vesicle fusion. However, the standard Ca(V)1>Ca(V)2>Ca(V)3 conductance hierarchy is based on recordings using nonphysiological divalent ion concentrations. We found that, with physiological Ca2+ gradients, the hierarchy was Ca(V)2.2>Ca(V)1>Ca(V)3. Mathematical modeling predicts that the Ca(V)2.2 Ca2+ nanodomain, which is similar to 25% more extensive than that generated by Ca(V)1, can activate a calcium-fusion sensor located on the proximal face of the synaptic vesicle.
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