期刊
NATURE NEUROSCIENCE
卷 12, 期 12, 页码 1485-1487出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.2428
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资金
- Howard Hughes Medical Institute Funding Source: Medline
The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na+ spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by localized downregulation of A-type K+ channel function. Thus, dendritic plasticity might be used to store recent experience in individual branches of the dendritic arbor.
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