Article
Clinical Neurology
Antia Reguera Acuna, Esther Suarez San Martin, Ciara Garcia Fernandez, Santiago Fernandez Menendez, Marta Blazquez Estrada, Manuel Amorin Diaz, Manuel Menendez Gonzalez, Victoria Alvarez Martinez
Summary: This study reviewed 14 cases of Intermediate Alleles (IAs) in the HTT gene, most of which exhibited some form of extrapyramidal symptoms. Cognitive and/or behavioral symptoms were also common in these cases.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hanna Antila, Iris Kwak, Ashley Choi, Alexa Pisciotti, Ivan Covarrubias, Justin Baik, Amelia Eisch, Kevin Beier, Steven Thomas, Franz Weber, Shinjae Chung
Summary: This study in mice found that acute psychosocial stress disrupts sleep by increasing brief arousals, reducing sleep spindles, and impairing infraslow oscillations during non-rapid eye movement sleep. The activity of noradrenergic neurons in the locus coeruleus was involved in this process. Inhibiting these neurons could improve sleep quality. The study also discovered the interaction between stress-regulatory noradrenergic neurons and the preoptic area of the hypothalamus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Zheyu Xu, Kirstie N. Anderson, Seyed Ehsan Saffari, Rachael A. Lawson, K. Ray Chaudhuri, David Brooks, Nicola Pavese
Summary: The study found that sleep disturbances in early Parkinson's disease patients increase over time, with insomnia being the most common issue, while a minority of patients receive treatment for their sleep disturbances.
JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
W. Xu, F. De Carvalho, A. K. Clarke, A. Jackson
Summary: Through long-term wireless recording, researchers characterized dynamic cerebro-thalamo-cerebellar interactions during natural sleep in monkeys. The observations suggest a contribution of the cerebellum to neocortical sleep spindles, potentially involving communication via cerebello-thalamo-neocortical pathways. The study highlights the complexity of neural activity in the sleeping cerebellum and its interaction with other brain regions during sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Cell Biology
Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Summary: Sleep spindles are essential for learning as they reactivate previously active neuronal ensembles. A study on non-human primates during sleep shows that spindles in the basal ganglia (BG) are similar to cortical spindles in morphology, spectral content, and response to pre-sleep tasks. Spiking activity in the striatal projection neurons is phase-locked to striatal and EEG spindles, while other BG nuclei do not show entrainment to spindles.
Article
Clinical Neurology
Martin Paucar, Jose Laffita-Mesa, Valter Niemela, Helena Malmgren, Inger Nennesmo, Kristina Lagerstedt-Robinson, Magnus Nordenskjold, Per Svenningsson
Summary: Screening of a Swedish cohort revealed two cases of SCA17, one case of IPD associated with 5-OPRI, but no nucleotide expansions in C9orf72 or HDL2, SCA2 or SCA3. In addition, two sporadic cases were diagnosed with SGCE-myoclonic-dystonia and benign hereditary chorea. Whole exome sequencing identified a variant of unknown significance in STUB1 in two patients with predominant cerebellar ataxia.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Sabrina Maffi, Eugenia Scaricamazza, Simone Migliore, Melissa Casella, Consuelo Ceccarelli, Ferdinando Squitieri
Summary: This study investigated the correlations between sleep features and motor, cognitive, behavioral, and functional changes in individuals with Huntington's disease (HD). The results showed a significant association between sleep abnormalities and the severity of disease progression, as well as impaired independence, cognitive performance, and motor functions. Sleep abnormalities are an important aspect of the clinical profile of HD and can greatly impact patients' quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Dieter Kunz, Sophia Stotz, Frederik Bes
Summary: The study found that clock-timed, low-dose, long-term melatonin treatment in patients with isolated REM sleep behavior disorder (iRBD) seems to be associated with symptom improvement, which can last for years, challenging the view of melatonin having purely symptomatic effects.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Clinical Neurology
Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeida, Gabriel Ginani Ferreira, Andrezza Paula Brito Silva, Pedro Renato de Paula Brandao, Wolfgang H. Oertel, Carlos H. Schenck, Raimundo Nonato Delgado Rodrigues
Summary: The flow of gene expression is a tightly controlled cell process, with microRNAs playing a crucial role in maintaining healthy cell physiology. Aberrant expressions of microRNAs are associated with Parkinson's disease pathogenesis, while REM-sleep behavior disorder may serve as a valuable phenotype for disease prediction.
Article
Neurosciences
Daniele Urso, Salvatore Nigro, Benedetta Tafuri, Valentina Gnoni, Marco Filardi, Roberto De Blasi, K. Ray Chaudhuri, Giancarlo Logroscino
Summary: This study investigated the association between Magnetic Resonance Parkinsonism Index (MRPI) and REM sleep behavior disorder (RBD). The findings showed that MRPI can serve as an imaging marker for RBD in de novo Parkinson's disease (PD) and idiopathic RBD (iRBD) patients.
Article
Clinical Neurology
Mitchell G. Miglis, Jennifer Zitser, Logan Schneider, Emmanuel During, Safwan Jaradeh, Roy Freeman, Christopher H. Gibbons
Summary: The study showed that a majority of iRBD patients have cutaneous p-syn and this is associated with autonomic dysfunction on testing. It is expected that longitudinal follow-up will help in predicting phenoconversion rates and future disease status.
Article
Clinical Neurology
Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sanchez-Gomez, Maria Paola Cecchini, Sara Mariotto, Sergio Ferrari, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, M. Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Hoegl, Werner Poewe, Gianluigi Zanusso
Summary: RT-QuIC detection of alpha-synuclein aggregates in olfactory mucosa showed a linkage between alpha-synuclein pathology and olfactory dysfunction in patients with isolated RBD and Parkinson's disease, indicating a potential for early detection and preventive therapies.
Article
Clinical Neurology
Mitchell G. Miglis, Jennifer Zitser, Logan Schneider, Emmanuel During, Safwan Jaradeh, Roy Freeman, Christopher H. Gibbons
Summary: The study found that cutaneous p-syn was detected in most iRBD patients and was associated with autonomic dysfunction on testing. Future research will help determine the predictive role of skin biopsy and autonomic testing in defining phenoconversion rates and future disease status.
Article
Clinical Neurology
Florian Holtbernd, Sandro Romanzetti, Wolfgang Hermann Oertel, Susanne Knake, Elisabeth Sittig, Anna Heidbreder, Andrea Maier, Janna Krahe, Jennifer Wojtala, Imis Dogan, Joerg Bernhard Schulz, Johannes Schiefer, Annette Janzen, Kathrin Reetz
Summary: Using MRI, we found similar patterns of structural brain alterations in RBD and PD patients, suggesting a continuum in disease spectrum between the two.
Article
Biochemistry & Molecular Biology
Shinya Okuda, Takeo Nakayama, Norihito Uemura, Rie Hikawa, Masashi Ikuno, Hodaka Yamakado, Haruhisa Inoue, Naoko Tachibana, Yu Hayashi, Ryosuke Takahashi, Naohiro Egawa
Summary: The accumulation of alpha-synuclein is the main feature of alpha-synucleinopathy, with rapid eye movement sleep behavior disorder being a key manifestation of this condition, clinically confirmed by REM sleep without atonia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Milan Nigam, Amandine Hippolyte, Pauline Dodet, Ana Gales, Jean-Baptiste Maranci, Saba Al-Youssef, Smaranda Leu-Semenescu, Isabelle Arnulf
Summary: This study assessed the impact of COVID-19-related restrictions on different types of narcolepsy. The results showed that during the lockdown, people experienced longer sleep time and decreased sleepiness. Teleworkers had a greater increase in sleep time. Some participants enjoyed the lockdown, while others felt isolated and psychologically distressed.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Ana Branquinho Bras, Jean-Baptiste Maranci, Zhongmei Yang, Charlotte Chaumereuil, Isabelle Arnulf
Summary: This study described the duration, motor patterns, and autonomic patterns associated with arousals in normal subjects across different sleep stages. The findings suggest that most arousals are associated with movements, indicating that arousal may be an intermediary state between wakefulness and sleep.
Article
Multidisciplinary Sciences
Jean-Baptiste Maranci, Milan Nigam, Luc Masset, Eva-Flore Msika, Marie Charlotte Vionnet, Charlotte Chaumereil, Marie Vidailhet, Smaranda Leu-Semenescu, Isabelle Arnulf
Summary: Growing evidence suggests that sleep plays a crucial role in regulating emotions. This study found an association between REM sleep and slow eye movements (SEMs), as well as dream emotions.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yuri L. Sosero, Eric Yu, Mehrdad A. Estiar, Lynne Krohn, Kheireddin Mufti, Uladzislau Rudakou, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Jean-Francois Trempe, Timothy G. Quinnell, Nicholas Oscroft, Isabelle Arnulf, Jacques Y. Montplaisir, Jean-Francois Gagnon, Alex Desautels, Yves Dauvilliers, Gian Luigi Gigli, Mariarosaria Valente, Francesco Janes, Andrea Bernardini, Karel Sonka, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Francesco Biscarini, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Doering, Valerie Cochen De Cock, Christelle Charley Monaca, Anna Heidbreder, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F. Boeve, Ronald B. Postuma, Guy A. Rouleau, Abubaker Ibrahim, Ambra Stefani, Birgit Hogl, Michele T. M. Hu, Ziv Gan-Or
Summary: This study found that loss-of-function mutations in the PSAP gene were present in patients with iRBD, and the co-occurrence with GBA variants suggests a potential genetic interaction. These findings may have implications for understanding the prodromal stage of synucleinopathy and the development of Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Medicine, General & Internal
Valerie Attali, Olivier Jacq, Karine Martin, Isabelle Arnulf, Thomas Similowski
Summary: The study found that the manipulation of the sphenopalatine ganglia (SPG) is not effective for treating obstructive sleep apnoea syndrome (OSAS), but it can reduce nasal obstruction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Shady Rahayel, Christina Tremblay, Andrew Vo, Ying Qiu Zheng, Stephane Lehericy, Isabelle Arnulf, Marie Vidailhet, Jean Christophe Corvol, Jean Francois Gagnon, Ronald B. Postuma, Jacques Montplaisir, Simon Lewis, Elie Matar, Kaylena Ehgoetz Martens, Per Borghammer, Karoline Knudsen, Allan Hansen, Oury Monchi, Bratislav Misic, Alain Dagher
Summary: The brain atrophy in patients with isolated REM sleep behavior disorder (iRBD) can be explained by the dynamics of alpha-synuclein, and it can be recreated using an agent-based modeling approach. This finding supports the concepts of prion-like spread and regional susceptibility in prodromal synucleinopathies.
Review
Clinical Neurology
Birgit Hoegl, Isabelle Arnulf, Melanie Bergmann, Matteo Cesari, Ziv Gan-Or, Anna Heidbreder, Alex Iranzo, Lynne Krohn, Pierre-Herve Luppi, Brit Mollenhauer, Federica Provini, Joan Santamaria, Claudia Trenkwalder, Aleksandar Videnovic, Ambra Stefani
Summary: This manuscript provides an overview of REM sleep behaviour disorder (RBD), focusing on the contributions from European researchers. It covers the history, pathophysiology, clinical aspects, diagnostic issues, and the implications of RBD diagnosis and biomarkers.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Clinical Neurology
Yannis Idir, Delphine Oudiette, Isabelle Arnulf
Summary: Disorders of arousal (DOA) include not only classical sleepwalking, sleep terrors, and confusional arousals, but also other forms of sleep disorders such as sexsomnia, sleep-related eating disorder, and sleep-related choking syndrome. DOA is not only common in children but also prevalent in adults. Adults with DOA often suffer from excessive daytime sleepiness, pain, and decreased quality of life. Recent research challenges the traditional view of DOA as automatic and amnesiac behaviors, suggesting that sleepwalkers may actually be "dream walking" during their episodes. Diagnostic criteria and treatment options for DOA have also improved, but further research is needed for effective treatment.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Valerie Cochen De Cock, Pauline Dodet, Smaranda Leu-Semenescu, Cecile Aerts, Giovanni Castelnovo, Beatriz Abril, Sophie Drapier, Helene Olivet, Anne-Gaelle Corbille, Laurene Leclair-Visonneau, Magali Sallansonnet-Froment, Marie Lebouteux, Mathieu Anheim, Elisabeth Ruppert, Nicolas Vitello, Alexandre Eusebio, Isabelle Lambert, Ana Marques, Maria Livia Fantini, David Devos, Christelle Monaca, Nicolas Benard-Serre, Sandy Lacombe, Marie Vidailhet, Isabelle Arnulf, Mohamed Doulazmi, Emmanuel Roze
Summary: This study investigated the safety and efficacy of subcutaneous night-time apomorphine infusion in treating insomnia in patients with Parkinson's disease. The results showed that this treatment significantly improved sleep disturbances and had an overall good safety profile.
Article
Neurosciences
P. A. Geoffroy, C. M. Schroder, P. Bourgin, J. Maruani, M. Lejoyeux, M. -P. d'Ortho, C. Couffignal, P. Philip, I. Arnulf, S. Royant-Parola, D. Leger, B. Gohier, F. Gagnadoux, A. Amad, I. Poirot, R. Gaillard, F. Limosin, R. Delorme, R. Jardri, P. Fossati, C. Dubertret, B. Rolland, B. Etain, F. Vorspan, B. Aouizerate, P. Courtet, J. L. Castroman, E. Haffen, D. Drapier, A. Dereux, R. Schwan, A. Luquiens, B. Abril, M. Auriacombe, A. Benyamina, R. Lopez, M. Grall-Bronnec, D. Bennabi, J. Frija-Masson, J. -A. Micoulaud Franchii, T. Schwitzer, J. -B. Maranci, U. K. Huck
Summary: To better identify biomarkers of sleep and biological rhythms and validate more homogeneous subgroups of patients with depressive disorders, a French national cohort was built. A Delphi process was conducted to achieve consensus and establish a validated data collection set of questionnaires to assess psychiatry, addiction, sleep, and chronobiology dimensions of depressive disorders.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2023)
Article
Clinical Neurology
Mwetty Onanga, Sarah Joanny, Isabelle Rivals, Elisa Perger, Isabelle Arnulf, Stefania Redolfi, Caroline Sevoz-Couche
Summary: The deep breathing technique accurately identifies a reduction in cardiac changes in patients with mild to moderate OSAS and can be used as a simple screening tool to select patients for polysomnography.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Luc Masset, Milan Nigam, Anne Ladarre, Marie Vidailhet, Smaranda Leu-Semenescu, Philippe Fossati, Isabelle Arnulf, Jean-Baptiste Maranci
Summary: Dreams during REM sleep can help reduce negative emotions, as shown by the study on emotional dynamics. Previous studies were limited to dream reports, but by studying individuals with REM sleep behavior disorder (RBD), researchers gained direct access to observe emotional dream behaviors. Analysis of 17 participants with RBD and 39.7 hours of REM sleep video revealed that emotional behaviors follow a biphasic temporal course, with an initial increase in frequency followed by a progressive decrease. Negative emotional behaviors occurred earlier than positive and neutral behaviors, and rapid succession of emotions of opposite valence was observed to prevent prolonged periods of negative emotions.
Article
Neuroimaging
Rahul Gaurav, Romain Valabregue, Lydia Yahia-Cherif, Graziella Mangone, Sridar Narayanan, Isabelle Arnulf, Marie Vidailhet, Jean-Christophe Corvol, Stephane Lehericy
Summary: This study developed an AI-based NigraNet framework for automated SNc segmentation and quantification of neuromelanin in patients with PD. The method showed good consistency and accuracy in PD patients and can be useful for clinical settings and large-scale neuroimaging studies.
NEUROIMAGE-CLINICAL
(2022)
Letter
Clinical Neurology
Anne-Laure Dubessy, Bruno Stankoff, Isabelle Arnulf
Article
Clinical Neurology
Yves Dauvilliers, Isabelle Arnulf, Nancy Foldvary-Schaefer, Anne Marie Morse, Karel Sonka, Michael J. Thorpy, Emmanuel Mignot, Patricia Chandler, Rupa Parvataneni, Jed Black, Amanda Sterkel, Dan Chen, Franck Skobieranda, Richard K. Bogan
Summary: Lower-sodium oxybate has been proven to be a safe and effective treatment for idiopathic hypersomnia.
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
