Article
Food Science & Technology
Mari Enokida, Ken-ichiro Minato, Susumu Yoshino, Nobuaki Ohto, Hiroshige Kuwahara, Masashi Mizuno
Summary: Research on food components with anti-allergic effects has gained attention in recent years. LP22A3 has been found to significantly improve allergic responses by reducing IgE production and restoring colon temperature. Furthermore, LP22A3 suppresses Th2 differentiation and IL-4 production by downregulating OX40L, thereby suppressing IgE production. These findings suggest that LP22A3 could be a safe and effective treatment for allergic diseases.
Review
Biochemistry & Molecular Biology
Ekaterina Belotserkovskaya, Oleg Demidov
Summary: Chronic myelomonocytic leukemia (CMML) is a rare and challenging myeloproliferative neoplasm with a high risk of progressing to secondary acute myeloid leukemia (sAML). Current therapeutic approaches are limited and controversial, leading to a focus on developing robust animal models for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Andrea L. Graham
Summary: Laboratory mice provide valuable insights into mammalian immune systems, but their immune phenotypes often differ from wild mammals. Recent efforts to naturalize the environment of inbred mice are poised to enhance understanding of natural selection's impact on immune systems.
Article
Oncology
Angelina T. Regua, Austin Arrigo, Daniel Doheny, Grace L. Wong, Hui-Wen Lo
Summary: Transgenic breast cancer mouse models are essential for preclinical studies, allowing for modeling of abnormal genetic events commonly seen in human breast cancers. By employing tissue-specific genetic manipulation, these models can mimic spontaneous mammary tumorigenesis by expressing oncogenes or deleting tumor suppressors. The variability in characteristics and strain-dependent features of these models can be utilized to study different aspects of mammary tumorigenesis and metastasis.
Review
Endocrinology & Metabolism
Mengyu Zhang, Wen Jiang, Ganghua Lu, Ru Wang, Zhongwei Lv, Dan Li
Summary: Hyperthyroidism is a condition characterized by excessive production of thyroid hormones, with Graves' disease being the most common cause. Disease models have been established, and novel treatments for Graves' disease and Graves' orbitopathy have been discovered. Potential therapeutic targets have also been identified in mouse models of Graves' orbitopathy. Human placental mesenchymal stem cells, fucoxanthin, and icariin may provide alternative therapies in addition to existing drugs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Wiebke Winkler, Carlota Farre Diaz, Eric Blanc, Hanna Napieczynska, Patrick Langner, Marvin Werner, Barbara Walter, Brigitte Wollert-Wulf, Tomoharu Yasuda, Arnd Heuser, Dieter Beule, Stephan Mathas, Ioannis Anagnostopoulos, Andreas Rosenwald, Klaus Rajewsky, Martin Janz
Summary: By targeting the expression of genes involved in MM subgroup-specific chromosomal translocations into mouse GC B cells, we have generated distinct MM-like disease models that recapitulate key features of human tumors, which provides insights into the pathogenesis and therapeutic vulnerabilities of different MM subgroups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Michael Daines, Rhea Pereira, Aubrey Cunningham, Barry Pryor, David G. G. Besselsen, Yuchen Liu, Qianwen Luo, Yin Chen
Summary: The study established novel fungal spore exposure models and found differences in the pathophysiological changes caused by exposure to Alternaria filtrates and spores, especially in their effects on BALB/c mice. Both adult and neonatal mice exposed to Alternaria spores showed increased airway hyperresponsiveness, elevated IgE levels, and increased eosinophils.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Oncology
Marcus Bosenberg, Edison T. Liu, Chun I. Yu, Karolina Palucka
Summary: Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms and treatment limiting toxicity. Preclinical in vivo models and technologies are needed to address these knowledge gaps and overcome challenges in clinical application. Mice are commonly used for research to support immune intervention development and testing.
Editorial Material
Immunology
Erica Moore, Joshua A. Reynolds, Anne Davidson, Stefania Gallucci, Laurence Morel, Deepak A. Rao, Howard A. Young, Chaim Putterman
Summary: The virtual conference "Mouse models of lupus 10 years later" convened in December 10, 2020, aimed to address the challenges and lack of new therapies approved in the past decade despite significant leaps in knowledge.
Review
Medicine, General & Internal
Batoul Wehbi, Virginie Pascal, Lina Zawil, Michel Cogne, Jean-Claude Aldigier
Summary: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world, with patients showing a wide range of clinical features and histological lesions. Small-animal models provide valuable insights into the pathogenesis and progression of IgAN.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Amandine Jullienne, Michelle V. Trinh, Andre Obenaus
Summary: MRI and PET technologies play important roles in the diagnosis and research of Alzheimer's Disease, with mouse models also contributing to our understanding of the disease on a cellular and molecular level. Researchers have focused on popular mouse models such as 3xTg-AD and 5xFAD, summarizing known MRI and PET imaging data. The goal is to provide a framework for future studies in AD mouse models and suggest improvements in rigor and reproducibility in future imaging studies.
Review
Biochemistry & Molecular Biology
Martina Perse
Summary: The paper summarizes the use of cisplatin in mouse models and existing issues, as well as recommendations for improvements in future research, emphasizing the similarities in response to cisplatin treatment between humans and mice.
Article
Biochemistry & Molecular Biology
Tae Hoon Kim, Nayoung Bae, Taeho Kim, Albert L. Hsu, Mark Hunter, Jung-Ho Shin, Jae-Wook Jeong
Summary: Endometriosis is positively associated with obesity, but negatively associated with low BMI. High-fat diet-induced obesity can increase the development of endometriosis, while obesity with leptin deficiency and leptin receptor deficiency can suppress the development of endometriosis. These findings suggest that leptin and its receptor play a critical role in the development of endometriosis.
Review
Cell Biology
William H. Hicks, Cylaina E. Bird, Jeffrey I. Traylor, Diana D. Shi, Tarek Y. El Ahmadieh, Timothy E. Richardson, Samuel K. McBrayer, Kalil G. Abdullah
Summary: Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing using murine models, such as xenograft, syngeneic, and genetically engineered models, to study tumor progression and test novel treatment strategies. Improvements in preclinical models that capture the phenotypic and molecular heterogeneity of gliomas are critical for the development of effective new therapies.
Review
Microbiology
Ivana Kutle, Anne Dittrich, Dagmar Wirth
Summary: More than hundred herpesviruses have been identified, but only nine infect humans. Infections with herpesviruses pose a significant challenge to human health due to lifelong latency. Mouse models, particularly immunocompromised mice and xenograft mice, have been developed to study herpesvirus infections and human-restricted viruses. This review focuses on the various mouse models used in herpesvirus research, with an emphasis on xenograft models.