Review
Chemistry, Multidisciplinary
Francesca K. Lewns, Olga Tsigkou, Liam R. Cox, Ricky D. Wildman, Liam M. Grover, Gowsihan Poologasundarampillai
Summary: Advances in bioprinting have limitations in replicating the structural and biological complexity present in bone tissue. However, biomimetic approaches using hydrogels as a platform for cell signaling can enhance the biological function and development of tissue engineering models. The development of dynamic microenvironments for in vitro bone formation and remodeling is a major focus in bioprinting. Hydrogels and 3D bioprinting offer potential solutions to overcome these challenges in creating in vitro bone models.
ADVANCED MATERIALS
(2023)
Article
Plant Sciences
Xuehuan Dai, Jing Wang, Lili Wang, Zhenhua Liu, Qiang Li, Yunfei Cai, Shuo Li, Fengning Xiang
Summary: This study investigates the role of light signaling factor HY5 in shoot regeneration and reveals its inhibitory mechanism on the formation of shoot stem cell niches by directly and indirectly repressing the expression of CLV3 and WUS genes.
Article
Multidisciplinary Sciences
Ben S. Carlson, Shay Rotics, Ran Nathan, Martin Wikelski, Walter Jetz
Summary: Individual variation plays a key role in shaping environmental niche associations, with individual environmental niches of white storks showing high consistency over time and a tendency towards moderate to strong niche specialization.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Fatmah I. Ghuloum, Colin A. Johnson, Natalia A. Riobo-Del Galdo, Mahetab H. Amer
Summary: This review provides an overview of the role of Hedgehog signalling and mechanobiology in bone development and regeneration, highlighting the importance of Hedgehog signalling pathway response to mechanical cues in bone marrow-derived mesenchymal stromal cells and osteogenesis. Different tissue engineering strategies are proposed to apply the knowledge of 3D material-cell interactions in the modulation of Hedgehog signalling for research applications.
MATERIALS TODAY BIO
(2022)
Review
Materials Science, Biomaterials
Jing Hong, Wenlong Zheng, Xiaoqiong Wang, Ying Hao, Guosheng Cheng
Summary: This review discusses recent advances in the use of biomedical polymer scaffolds to mimic bone marrow microenvironments for in vitro expansion of hematopoietic stem cells (HSCs), highlighting the potential future prospects in this field.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Kyle H. Vining, Anna E. Marneth, Kwasi Adu-Berchie, Joshua M. Grolman, Christina M. Tringides, Yutong Liu, Waihay J. Wong, Olga Pozdnyakova, Mariano Severgnini, Alexander Stafford, Georg N. Duda, F. Stephen Hodi, Ann Mullally, Kai W. Wucherpfennig, David J. Mooney
Summary: Myelofibrosis causes pathological remodelling of the bone marrow, leading to increased stiffness and elasticity, thereby promoting the proliferation of proinflammatory monocytes and their differentiation into dendritic cells.
Review
Immunology
Angelina De Martin, Yves Stanossek, Natalia Barbara Pikor, Burkhard Ludewig
Summary: This article discusses the biology of fibroblastic reticular cells (FRCs) in lymphoid organs and their role in activating or attenuating immune responses. FRCs provide structural support in secondary lymphoid organs and guide immune cells to specialized microenvironments. Adverse reprogramming of FRCs can lead to immunopathological tissue damage during infection and autoimmune conditions, as well as subvert antitumor immune responses.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Myriam Janeth Salazar-Terreros, Jean-Paul Vernot
Summary: Cellular senescence is a dynamic process where cells adapt to their environment, and can have both beneficial and harmful effects on their surroundings. Senescent mesenchymal stromal cells in the bone marrow have been linked to enhanced survival of malignant cells. However, studying the role of senescence in leukemia development is challenging due to lack of suitable models and standardized methods for measuring senescence. Advances have been made in improving in vitro models and developing techniques to track leukemic and senescent cells in living organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yannick O. Alexandre, Scott N. Mueller
Summary: In the spleen, a complex microanatomy consisting of fibroblastic stromal cells and neuronal cells supports splenic function and immune responses. The spleen plays a crucial role in initiating and sustaining immune responses against blood-borne pathogens. Stromal cells in the spleen construct microanatomical niches that contribute to physiological spleen functions and regulate immune cell homeostasis. Recent understanding of splenic fibroblastic stromal cell diversity has improved our knowledge of how these cells orchestrate splenic responses to infection and contribute to immune responses. This review focuses on the role of stromal niches and neuroimmune circuits in directing T cell immunity in the spleen.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jizhou Zhang, Qingqing Wu, Courtney B. Johnson, Giang Pham, Jeremy M. Kinder, Andre Olsson, Anastasiya Slaughter, Margot May, Benjamin Weinhaus, Angelo D'Alessandro, James Douglas Engel, Jean X. Jiang, J. Matthew Kofron, L. Frank Huang, V. B. Surya Prasath, Sing Sing Way, Nathan Salomonis, H. Leighton Grimes, Daniel Lucas
Summary: This study develops imaging approaches for myelopoiesis in mice and generates atlases showing the differentiation of granulocytes, monocytes, and dendritic cells in the bone marrow. It reveals that local cues from distinct blood vessels are responsible for the spatial organization of definitive blood cell differentiation.
Article
Cell Biology
Cerise Tang, Amy X. Xie, Eric Minwei Liu, Fengshen Kuo, Minsoo Kim, Renzo G. Dinatale, Mahdi Golkaram, Ying-Bei Chen, Sounak Gupta, Robert J. Motzer, Paul Russo, Jonathan Coleman, Maria I. Carlo, Martin H. Voss, Ritesh R. Kotecha, Chung -Han Lee, Wesley Tansey, Nikolaus Schultz, Ari Hakimi, Ed Reznik
Summary: The availability of local metabolites shapes tumor cell phenotypes and anti-tumor immune responses, but the understanding of intratumoral metabolite heterogeneity (IMH) and its phenotypic consequences remains limited. Through analyzing clear cell renal cell carcinoma (ccRCC) patients, a common pattern of IMH was identified, characterized by fluctuations in metabolites associated with ferroptosis. The variations in intratumoral metabolites were driven by the immune composition of the microenvironment, particularly the abundance of myeloid cells. By inferring metabolomic profiles from RNA sequencing data, metabolite biomarkers associated with response to anti-angiogenic agents in ccRCC patients were identified.
Review
Immunology
Thomas Menter, Alexandar Tzankov
Summary: This review examines the complex relationship between leukemic cells and the tumor microenvironment in AML, focusing on niche cells and T-cell subsets, and explores potential therapeutic strategies for manipulating the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, Jan Patrick Pett, Krzysztof Polanski, Laura Richardson, Monika Litvinukova, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukas Mach, Monika Dabrowska, Nathan Richoz, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam N. Barnett, Shani Perera, Carlos Talavera-Lopez, Ilaria Mulas, Krishnaa T. Mahbubani, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hubner, Rasheda A. Chowdhury, Michela Noseda, Sarah A. Teichmann
Summary: In this study, single-cell and spatial transcriptomics data were used to explore cellular niches in eight regions of the human heart. Specific ion channels, G-protein-coupled receptors, and regulatory networks were identified in different cell types, highlighting the importance of FOXP2 in pacemaker cells. The sinoatrial node was found to be compartmentalized, with glial cells and fibroblasts supporting glutamatergic signaling. The study also introduced a drug target prediction tool, drug2cell, and revealed the presence of immune niches in the epicardium.
Article
Biology
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf, Ben D. MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Summary: Protection of telomeres 1a (POT1a) is crucial for maintaining the stability of the bone marrow microenvironment and supporting B-lymphopoiesis. Deletion of POT1a in mesenchymal stem cells (MSCs) may lead to bone marrow dysfunction and myeloid skewing.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biodiversity Conservation
K. M. MacKenzie, C. Lydersen, T. Haug, H. Routti, J. Aars, C. M. Andvik, K. Borga, A. T. Fisk, S. Meier, M. Biuw, A. D. Lowther, U. Lindstrom, K. M. Kovacs
Summary: The Arctic is warming rapidly, posing a threat to marine mammals and their ecosystem. The study of stable isotopes and trophic webs reveals clear separation in trophic behavior and carbon sources among different species, indicating significant niche partitioning. This could have implications for the structure and connectivity of the Arctic ecosystem.
ECOLOGICAL INDICATORS
(2022)