Taming the isobaric tagging elephant in the room in quantitative proteomics

Gas-phase purification enables accurate, multiplexed proteome quantification with isobaric tagging

(2011) Craig D Wenger et al.   NATURE METHODS

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

Undesirable Charge-Enhancement of Isobaric Tagged Phosphopeptides Leads to Reduced Identification Efficiency

(2010) Tine E. Thingholm et al.   JOURNAL OF PROTEOME RESEARCH

A comparison of the accuracy of iTRAQ quantification by nLC-ESI MSMS and nLC-MALDI MSMS methods

(2010) Sally L. Shirran et al.   Journal of Proteomics

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

(2010) Mikhail M. Savitski et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Addressing Accuracy and Precision Issues in iTRAQ Quantitation

(2010) Natasha A. Karp et al.   MOLECULAR & CELLULAR PROTEOMICS

High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of All

(2009) Thomas Köcher et al.   JOURNAL OF PROTEOME RESEARCH

iTRAQ Underestimation in Simple and Complex Mixtures: “The Good, the Bad and the Ugly”

(2009) Saw Yen Ow et al.   JOURNAL OF PROTEOME RESEARCH

A Robust Error Model for iTRAQ Quantification Reveals Divergent Signaling between Oncogenic FLT3 Mutants in Acute Myeloid Leukemia

(2009) Yi Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS