Article
Medicine, Research & Experimental
Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jian Xiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du, Zhongxing Jiang
Summary: GM-CSF treatment impairs EBI formation and functions by decreasing adhesion molecule expression and phagocytic ability of EBI macrophages, as well as inducing polarization from M2-like to M1-like type. This finding suggests that targeting GM-CSF or reprogramming EBI macrophages could be a potential strategy for treating anemia in inflammatory diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Genetics & Heredity
Kaustav Mukherjee, James J. Bieker
Summary: This study focuses on characterizing the central macrophage of the erythroblastic island niche, revealing distinct cell types and widespread cellular heterogeneity, as well as transcriptional programs driving gene expression. The master erythroid regulator EKLF/Klf1 appears to also play a major role in gene expression in island macrophages, including a putative EKLF/Klf1-dependent transcription circuit.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Wei Li, Rongqun Guo, Yongping Song, Zhongxin Jiang
Summary: Erythroblastic islands (EBIs) are specialized microenvironments for erythropoiesis, consisting of a central macrophage and developing erythroid cells. EBI macrophages play a crucial role in supporting erythropoiesis, and dysfunction may lead to certain erythroid hematological disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Katarzyna Okreglicka, Irina Iten, Lea Pohlmeier, Lucas Onder, Qian Feng, Michael Kurrer, Burkhard Ludewig, Peter Nielsen, Christoph Schneider, Manfred Kopf
Summary: PPAR gamma and Spi-C are crucial for maintaining the identity, cell cycling, migration, and localization of splenic iron-recycling red pulp macrophages and bone marrow erythroblastic island macrophages, but do not affect function in mature red pulp macrophages. Lack of Spi-C leads to loss of identity in red pulp macrophages, while deficiencies in Pparg and Spic results in shared transcriptional changes in the cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Hematology
Jian Bai, Fan Fan, Chunchen Gao, Shaohua Li, Wei Li, Tiaoxia Wei, Shilin Cheng, Jinmin Yu, Chao Zheng, Junlong Zhao, Linru Zou, Lei Feng, Jing Yi, Hongyan Qin
Summary: CD169, a member of the Siglec family, plays a role in cell-cell interaction in erythroblastic island (EBI) formation. The counter receptor for CD169 in EBI formation is CD43 expressed by early erythroblasts (EB). CD169 deficiency impairs erythroid differentiation under stress erythropoiesis, possibly through the interaction with CD43. This study provides insights into the role of CD169 in EBI and suggests the potential of targeting the CD169-CD43 interaction for erythroid disorders.
Article
Immunology
Hao Huang, Peng-Yang Yu, Chen Wei, Yang-Wei Li, Li-Jie Liang, Yu-Zhang Liu, Li-Na Liu, Bai-Jun Fang, Yao-Mei Wang
Summary: The clinical characteristics and anemia-related factors in newly diagnosed multiple myeloma (NDMM) patients were examined in this study, along with the role and mechanism of erythroblastic islands (EBIs) and EBI macrophages in NDMM patients with anemia. Risk factors for anemia in NDMM patients were identified, including MCV, abnormal levels of albumin, osteolytic lesions, and Durie-Salmon (DS) stage. Anemia patients had fewer erythroblasts, EBIs, and EBI macrophages in their bone marrow. Impaired EBI macrophages in anemia patients were found to promote the production of interleukin-6, which is a critical survival factor for myeloma cells. This study highlights the significance of EBI macrophages in anemia in NDMM patients and suggests a new strategy for anemia recovery.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Editorial Material
Hematology
Deena Iskander
Summary: Research in murine bone marrow has discovered the presence of erythromyeloblastic islands (EMBI) where granulocyte and erythroid precursors develop around a central macrophage. This finding reveals an inverse relationship between the numbers of erythroid and granulocyte lineage cells in EMBI, which can vary in response to microenvironmental cues. These findings have important implications for understanding anemia of inflammation/chronic disease.
Article
Environmental Sciences
Farrage M. Khaleal, Mohamed A. Tahoon, Gehad M. Saleh, Mohamed S. Kamar, Hesham M. H. Zakaly, Ibrahim H. Zidan, Bandar A. Al-Mur, Saad S. Alarif, El Saeed R. Lasheen
Summary: The objective of this study is to assess the natural resources and radiological risks of Wadi El Gemal Island by examining its topography, mineralogy, geochemistry, and radioactive distributions. The island, situated at the outlet of Wadi El Gemal in Egypt's southeastern Desert, has unique features and diverse resources. Samples collected from the island were analyzed, and the concentration of radionuclides was found to be within acceptable levels.
MARINE POLLUTION BULLETIN
(2023)
Article
Hematology
Laurel Romano, Katie G. Seu, Julien Papoin, David E. Muench, Diamantis Konstantinidis, Andre Olsson, Katrina Schlum, Kashish Chetal, Joel Anne Chasis, Narla Mohandas, Betsy J. Barnes, Yi Zheng, H. Leighton Grimes, Nathan Salomonis, Lionel Blanc, Theodosia A. Kalfa
Summary: The erythroblastic island (EBI) is a specialized niche in the bone marrow where central macrophages are surrounded by maturing erythroblasts. This study shows that CD11b+ cells within the EBIs are neutrophil precursors specifically associated with BM EBI macrophages, indicating that the EBIs are sites for both granulopoiesis and erythropoiesis. The balance between these two differentiation programs is dynamically regulated within the BM niche. Furthermore, heterogeneity of EBI macrophages is revealed, providing insights into their role as hematopoietic niches.
Article
Cell Biology
Yuanqi Wang, Xiao Xiang, Huadong Chen, Luyao Zhou, Shuling Chen, Guopei Zhang, Xiaofei Liu, Xuxin Ren, Juncheng Liu, Ming Kuang, Juan Jiang, Jinbiao She, Zhichong Zhang, Ruidong Xue, Hong Jiang, Ji Wang, Sui Peng
Summary: By analyzing single-cell RNA sequencing data from 13 treatment-naive hepatoblastoma patients, researchers discovered the presence of aberrant accumulation of erythroblastic islands (EBIs), which are formed by VCAM1+ macrophages and erythroid cells, in the tumor microenvironment. This phenomenon is inversely correlated with the survival of hepatoblastoma. Erythroid cells inhibit the function of dendritic cells through the LGALS9/TIM3 axis, leading to impaired anti-tumor T cell immune responses. Blocking TIM3 can relieve the inhibitory effect of erythroid cells on dendritic cells.
CELL REPORTS MEDICINE
(2023)
Article
Immunology
Camille Mettler, Cassandre Petit, Vincent Ernest, Bouchra Asli, Marie-Therese Daniel, Stephanie Mathis, Jean Marc Zini, Benoit Faucher, Mikael Ebbo, Paul Legendre, Marion Malphettes
Summary: Erythroblastic synartesis is a rare cause of acquired dyserythropoiesis, which can be associated with monoclonal immunoglobulin and malignant lymphoid disorder. Treatment targeting the paraprotein seems to be efficient in controlling synartesis and correcting anemia.
CLINICAL IMMUNOLOGY
(2022)
Article
Environmental Sciences
Yingbin Deng, Renrong Chen, Yichun Xie, Jianhui Xu, Ji Yang, Wenyue Liao
Summary: This study investigated the impact of different types of building roofs on urban heat islands, finding significant differences in mean land surface temperatures among roof types during the hot season compared to the cool season, with varying degrees of impact on land surface temperatures. The contribution of roof types to land surface temperature variance was more substantial during the cool season.
Article
Engineering, Environmental
Jack Ngarambe, Soo Jeong Joen, Choong-Hee Han, Geun Young Yun
Summary: The study explores the interactions between urban heat island (UHI) and air pollution using in-situ temperature and air pollution data. It found positive correlations between certain air pollutants and UHI intensity (UHII), as well as strong seasonal effects on the strength of these correlations. Understanding these interactions is crucial for urban climate studies and mitigation strategies in Seoul city.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Instruments & Instrumentation
Yusen Luo, Yanan Yang, Sijing He, Mengxing Dou, Rui Wang, Tao Zhang, Jun Zhao, Fang Wang
Summary: This paper investigates the impact of industrial structure on the climate of surface urban heat islands (UHI) using long-wave infrared remote sensing technology (MODIS) and the STIRPAT model. It found that industrial structure upgrading has a significant and positive influence on UHI, with spatial and temporal heterogeneity. The threshold regression analysis revealed that there is a significant threshold effect of industrial structure upgrading on UHI. Furthermore, this study integrates infrared technology, satellite remote sensing, and environmental economics, and it will contribute to the sustainable development of human society.
INFRARED PHYSICS & TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Julia Kurek, Justyna Martyniuk-Peczek
Summary: The Urban Heat Island (UHI) effect poses a growing challenge for contemporary cities in the face of climate change and temperature fluctuations. Strategies to mitigate and adapt to the UHI effect should align with ecological and low-carbon city principles. Collaborative efforts and participatory decision-making processes are essential for successful and socially equitable mitigation and adaptation to the UHI effect.
Article
Endocrinology & Metabolism
Martina Rauner, Kristin Franke, Marta Murray, Rashim Pal Singh, Sahar Hiram-Bab, Uwe Platzbecker, Max Gassmann, Merav Socolovsky, Drorit Neumann, Yankel Gabet, Triantafyllos Chavakis, Lorenz C. Hofbauer, Ben Wielockx
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Article
Multidisciplinary Sciences
Yung Hwang, Melinda Futran, Daniel Hidalgo, Ramona Pop, Divya Ramalingam Iyer, Ralph Scully, Nicholas Rhind, Merav Socolovsky
Article
Hematology
Betsabeh Khoramian Tusi, Merav Socolovsky
EXPERIMENTAL HEMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Caleb Weinreb, Samuel Wolock, Betsabeh K. Tusi, Merav Socolovsky, Allon M. Klein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Hematology
Miroslav Koulnis, Ermelinda Porpiglia, P. Alberto Porpiglia, Ying Liu, Kelly Hallstrom, Daniel Hidalgo, Merav Socolovsky
Article
Biochemistry & Molecular Biology
Byoung Heon Kang, Fang Xia, Ramona Pop, Takehiko Dohi, Merav Socolovsky, Dario C. Altieri
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Multidisciplinary Sciences
Betsabeh Khoramian Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang, Daniel Hidalgo, Rapolas Zilionis, Ari Waisman, Jun R. Huh, Allon M. Klein, Merav Socolovsky
Article
Multidisciplinary Sciences
Miroslav Koulnis, Ying Liu, Kelly Hallstrom, Merav Socolovsky
Article
Multidisciplinary Sciences
Jeffrey R. Shearstone, Ramona Pop, Christoph Bock, Patrick Boyle, Alexander Meissner, Merav Socolovsky
Article
Biochemistry & Molecular Biology
Ermelinda Porpiglia, Daniel Hidalgo, Miroslav Koulnis, Abraham R. Tzafriri, Merav Socolovsky
Article
Multidisciplinary Sciences
Miroslav Koulnis, Ramona Pop, Ermelinda Porpiglia, Jeffrey R. Shearstone, Daniel Hidalgo, Merav Socolovsky
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2011)
Article
Rheumatology
Sudesh Pawaria, Kerstin Nundel, Kevin M. Gao, Stephanie Moses, Patricia Busto, Kevin Holt, Rohit B. Sharma, Michael A. Brehm, Ellen M. Gravallese, Merav Socolovsky, Anette Christ, Ann Marshak-Rothstein
ARTHRITIS & RHEUMATOLOGY
(2020)
Editorial Material
Cell Biology
Monica J. Justice, Julija Hmeljak, Vijay G. Sankaran, Merav Socolovsky, Leonard I. Zon
DISEASE MODELS & MECHANISMS
(2020)
Article
Medicine, Research & Experimental
Yung Hwang, Daniel Hidalgo, Merav Socolovsky
Summary: The length of the cell cycle influences the balance between self-renewal and differentiation, determining the fate of cell lineages. Regulation of different cell cycle stages plays a role in developmental decisions.
WIRES MECHANISMS OF DISEASE
(2021)
