Article
Biochemistry & Molecular Biology
Tao Wu, Huaijun Ma, Ping He, Cheng Zhang, Qingchen Wu
Summary: Interleukin-17 (IL-17) family consists of pro-inflammatory cytokines, with IL-17E/IL-25 playing a crucial role in the pathogenesis of autoimmune diseases. IL-25 activates nuclear factor kappa-light-chain enhancer of activated B cells by binding to its unique receptor IL-17Rb. IL-25 primarily interacts with IL-17Rb through linear and cyclic epitopes, which enhance its binding potency to IL-17Rb.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Lydia Koch, Birte Kespohl, Maria Agthe, Tim Schumertl, Stefan Dusterhoft, Marius K. Lemberg, Juliane Lokau, Christoph Garbers
Summary: Interleukin-11 (IL-11) activates target cells through different signaling pathways, including the shedding of IL-11R triggered by RHBDL2. RHBDL2 can cleave IL-11R within the cell, generating biologically active sIL-11R capable of trans-signaling IL-11 action.
Article
Oncology
Nicolo Bancaro, Bianca Cali, Martina Troiani, Angela Rita Elia, Rydell Alvarez Arzola, Giuseppe Attanasio, Ping Lai, Mateus Crespo, Bora Gurel, Rita Pereira, Christina Guo, Simone Mosole, Daniela Brina, Mariantonietta D'Ambrosio, Emiliano Pasquini, Clarissa Spataro, Elena Zagato, Andrea Rinaldi, Mattia Pedotti, Simona Di Lascio, Francesco Meani, Monica Montopoli, Matteo Ferrari, Andrea Gallina, Luca Varani, Ricardo Pereira Mestre, Marco Bolis, Silke Gillessen Sommer, Johann de Bono, Arianna Calcinotto, Andrea Alimonti
Summary: Tumor cells promote the recruitment of immunosuppressive neutrophils, a subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. We have identified a subset of neutrophils that have upregulated expression of cellular senescence markers and persist in the tumor microenvironment. These senescent-like neutrophils express TREM2 and are more immunosuppressive and tumor-promoting than canonical immunosuppressive neutrophils.
Article
Veterinary Sciences
Gerardo A. Abascal-Ponciano, Samuel F. Leiva, Joshua J. Flees, Luis P. Avila, Jessica D. Starkey, Charles W. Starkey
Summary: Vitamin D signaling plays an important role in maintaining intestinal homeostasis by regulating cell phenotype and cytokine secretion. Inflammation in intestinal tissues can disrupt the cell structure and compromise the protective barrier. This study found that dietary supplementation with 25OHD3 can decrease the abundance of inflammatory cytokines in the ileum of broiler chickens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Dewei Li, Abidan Ainiwaer, Xuran Zheng, Maolin Wang, Yang Shi, Zibigu Rousu, Xinling Hou, Xuejiao Kang, Muesier Maimaiti, Hui Wang, Jing Li, Chuanshan Zhang
Summary: Infection with the cestode Echinococcus multilocularis (E. multilocularis) causes alveolar echinococcosis (AE), which is a tumor-like disease that predominantly affects the liver but can spread to any organ. High expression of the inhibitory receptor LAG3 promotes the formation of Th2 cells and Tregs, resulting in immune tolerance and disease progression in chronic E. multilocularis infection. LAG3 deficiency enhances the type 1 CD4(+) T-cell immune response and inhibits metacestode growth in vivo. These findings suggest that LAG3 blockade may be an effective immunotherapeutic strategy against AE.
Article
Biochemistry & Molecular Biology
Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng, Yan-Heng Zhou, Qihong Yan, Ling Chen, Guo-Ying Yu, Junbiao Chang, Xia Jin, Jincun Zhao, Xin-Wen Chen, Yong-Tang Zheng, Jian-Hua Wang
Summary: The study revealed that SARS-CoV-2 infection induces mast cell degranulation, leading to lung inflammation and injury. Clinical mast cell stabilizers have been shown to dampen the inflammatory response and prevent lung injury caused by viral infection.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Antonella Antonelli, Emanuele Salvatore Scarpa, Santina Bruzzone, Cecilia Astigiano, Francesco Piacente, Michela Bruschi, Alessandra Fraternale, Christian A. A. Di Buduo, Alessandra Balduini, Mauro Magnani
Summary: Sinusoidal endothelial cells in the bone marrow play a crucial role in supporting the hematopoietic stem and progenitor cells by providing necessary signals for their self-renewal, survival, and differentiation. However, the low oxygen tension in the bone marrow affects these functions. In this study, we investigated how endothelial cells respond to a decrease in oxygen levels and found that the expression of certain genes involved in intercellular communication is regulated by SIRT6 under extreme hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Suiting Ao, Xuemei Gao, Jipang Zhan, Lu Ai, Minyi Li, Huilin Su, Xuhua Tang, Coco Chu, Jiande Han, Fang Wang
Summary: The combination of TNF-alpha inhibition and steroids showed better outcomes in treating SJS/TEN compared to steroid monotherapy, significantly shortening the duration of acute phase, hospitalization stay, and skin reepithelialization time. IL-15 was positively correlated with skin reepithelialization time in both groups, while IL-6 served as an additional marker for disease progression in the combination therapy group.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Oncology
Yin Wang, Xiao Tang, Yu Zhu, Xiao-xiao Yang, Bei Liu
Summary: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, characterized by immune disorders. Interleukins (ILs) and other cytokines play various roles in the immune system, affecting AML progression and response to treatment. Understanding the complex roles of ILs in AML can provide insights for disease monitoring, prognosis assessment, and development of novel treatment strategies.
LEUKEMIA & LYMPHOMA
(2023)
Article
Multidisciplinary Sciences
Julia K. Pfromm, Mario Bonillo, Daniyar Dauletbekov, Kirsten Bucher, M. Dominik Fischer
Summary: This study investigates the immunogenic potential of Cas9 in retinal cells and found that Cas9 does not induce immune responses in microglia cells but does in ARPE-19 cells, suggesting cell type-specific immune responses to Cas9.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sabina Kaczanowska, Daniel W. Beury, Vishaka Gopalan, Arielle K. Tycko, Haiying Qin, Miranda E. Clements, Justin Drake, Chiadika Nwanze, Meera Murgai, Zachary Rae, Wei Ju, Katherine A. Alexander, Jessica Kline, Cristina F. Contreras, Kristin M. Wessel, Shil Patel, Sridhar Hannenhalli, Michael C. Kelly, Rosandra N. Kaplan
Summary: By utilizing genetically engineered myeloid cells to deliver IL-12, immune suppression in the premetastatic niche can be reversed, resulting in improved survival and reduced metastatic and primary tumor burden in tumor-bearing mice.
Article
Allergy
Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
Summary: This study demonstrated that inhaled chitin induces airway inflammation, airway hyperresponsiveness, and production of IL-1 beta in mouse models. Furthermore, chitin-induced airway inflammation and hyperresponsiveness in mouse models were found to be steroid-resistant, which may contribute to features of steroid-resistant asthma.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Anna Chashchina, Melanie Maerklin, Clemens Hinterleitner, Helmut R. Salih, Jonas S. Heitmann, Boris Klimovich
Summary: The study revealed a widespread expression of DNAM-1 in leukemic cells of acute myeloid leukemia (AML) patients, and the expression of DNAM-1 was significantly associated with disease progression and survival time. This suggests that DNAM-1 may serve as a potential novel prognostic marker in AML.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Rui Li, Ramin Salehi-Rad, William Crosson, Milica Momcilovic, Raymond J. Lim, Stephanie L. Ong, Zi Ling Huang, Tianhao Zhang, Jensen Abascal, Camelia Dumitras, Zhe Jing, Stacy J. Park, Kostyantyn Krysan, David B. Shackelford, Linh M. Tran, Bin Liu, Steven M. Dubinett
Summary: Loss of LKB1 leads to increased secretion of ELR+ CXC chemokines in NSCLC, promoting the enrichment of G-MDSCs and immunosuppression. Treatment with ATRA enhances tumor sensitivity to PD-1 blockade, suggesting a potential strategy for overcoming immunotherapy resistance in LKB1-deficient NSCLC.
Article
Multidisciplinary Sciences
Mona Dixon Gundersen, Kenneth Bowitz Larsen, Kay Martin Johnsen, Rasmus Goll, Jon Florholmen, Guttorm Haraldsen
Summary: This study found that IL-33 in colonic mucosa is mainly induced by hypo-osmotic stress rather than inflammatory cytokines. This novel finding links a potent cytokine and alarmin of the innate immune system with cellular stress mechanisms and mucosal inflammation.
SCIENTIFIC REPORTS
(2022)