期刊
NATURE MEDICINE
卷 18, 期 11, 页码 1611-1612出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2980
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资金
- NHLBI NIH HHS [T32 HL066987] Funding Source: Medline
- NIAID NIH HHS [R01 AI102816] Funding Source: Medline
A long-standing question in the HIV field is why HIV-1 fails to replicate in resting CD4(+) T cells. A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) sterile a motif and histidine/aspartic domain-containing protein 1 (SAMHD1), previously shown to block HIV infection in myeloid cells, also restricts HIV replication in resting CD4(+) T cells by hydrolyzing dNTPs, which are needed for reverse transcription of the virus (pages 1682-1687).
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