Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Review
Neurosciences
Minkyung Kang, Yao Yao
Summary: Oligodendrocytes are crucial cells in the central nervous system responsible for myelinating axons and supporting the function of neurons. The function and development of oligodendrocytes are tightly regulated by various molecules, with laminin playing a significant role in processes such as survival, migration, proliferation, differentiation, and myelination. Understanding the specific molecular targets and signaling pathways in oligodendrocyte biology may have implications for therapeutic interventions in demyelinating diseases.
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Assia Tiane, Melissa Schepers, Renzo Riemens, Ben Rombaut, Patrick Vandormael, Veerle Somers, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
Summary: In this study, researchers identified Id2 and Id4 as targets of DNA methylation during the differentiation of oligodendrocyte precursor cells. Using CRISPR technology, they confirmed that methylation of Id2/Id4 could drive cell differentiation. Furthermore, they found alterations in methylation and gene expression levels of these genes in multiple sclerosis patients compared to controls.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen
Summary: This study reveals that the phosphorylation of FoxO1 by Akt plays a critical role in Sox10 expression and OL differentiation. Deletion of all three Akt isoforms leads to downregulation of Sox10, and mutant FoxO1 inhibits Sox10 promoter activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Developmental Biology
Jing An, Yumeng Zhang, Alexander D. Fudge, Haixia Lu, William D. Richardson, Huiliang Li
Summary: GPR37L1 is expressed in subsets of OL precursors and newly formed immature OLs in the adult mouse brain, and knockout of Gpr37l1 gene inhibits OP proliferation and differentiation, leading to a reduction in the number of adult-born OLs. This suggests that GPR37L1 may play a role in adult OL generation and adaptive myelination.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Neurosciences
Jinxing Hou, Huiru Bi, Zhuoyang Ye, Wenhui Huang, Gang Zou, Xiaochuan Zou, Yun Stone Shi, Ying Shen, Quanhong Ma, Frank Kirchhoff, Yimin Hu, Guiquan Chen
Summary: Mutations on gamma-secretase subunits are linked to neurological diseases. While the role of gamma-secretase in neurogenesis is well-studied, its involvement in astrogliogenesis remains unclear. Recent evidence suggests that astrocytes can be derived from oligodendrocyte precursor cells (OPCs), but the mechanism controlling this differentiation is not fully understood.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Yuki Miyamoto, Tomohiro Torii, Miho Terao, Shuji Takada, Akito Tanoue, Hironori Katoh, Junji Yamauchi
Summary: In mice, the atypical Rho family GTPase Rnd2 plays biphasic roles in oligodendrocyte myelination, promoting myelination in the early period and inhibiting myelination in the later period. This unique modulator thus exhibits different effects depending on the stage of myelination.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Review
Biochemistry & Molecular Biology
Shunqi Wang, Yingxing Wang, Suqi Zou
Summary: This article reviews the process of oligodendrocyte myelination and its regulatory factors, including proliferation, differentiation, and factors influencing myelination.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lingyu Shi, Zongyi Wang, Yujiao Li, Zheng Song, Wu Yin, Bing Hu
Summary: This study reveals the critical role of chd7 in oligodendrocyte migration and myelination in zebrafish, potentially associated with CHARGE syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ruyi Mei, Linyu Huang, Mengyuan Wu, Chunxia Jiang, Aifen Yang, Huaping Tao, Kang Zheng, Junlin Yang, Wanhua Shen, Xianjun Chen, Xiaofeng Zhao, Mengsheng Qiu
Summary: Itpr2 plays a crucial role in the developmental process of oligodendrocytes, with its deficiency leading to increased myelination of small-diameter axons by oligodendrocytes, hence affecting the normal functioning of the nervous system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jun Zhang, Jian-guang Sun, Xiaowen Xing, Rong Wu, Lujun Zhou, Ying Zhang, Fang Yuan, Shukun Wang, Zengqiang Yuan
Summary: In both developmental myelination and remyelination in the central nervous system, the c-Abl kinase plays a crucial role in the proliferation of OL progenitor cells by directly phosphorylating the transcription factor Olig2. Lack of c-Abl results in insufficient OPC proliferation and reduced expression of myelin-related genes, leading to impaired myelination.
Article
Cell Biology
Xiaoman You, Shanshan Zhu, Haowen Sheng, Zheng Liu, Dan Wang, Min Wang, Xiao Xu, Feng He, Hong Fang, Fan Zhang, Debao Wang, Zeyun Hao, Ruyi Wang, Yinghui Xiao, Jianmin Wan, Guo-Liang Wang, Yuese Ning
Summary: Knockdown of OsPEX5 enhances resistance to rice blast fungus Magnaporthe oryzae. OsPEX5 interacts with E3 ubiquitin ligase APIP6 to regulate plant immunity. Additionally, OsPEX5 interacts with OsALDH2B1 to enhance its repression of defense gene expression.
Article
Multidisciplinary Sciences
Yao Yu, Rong-Rong Wang, Nai-Jun Miao, Jia-Jie Tang, Yun-Wei Zhang, Xiang-Ran Lu, Pei-Yi Yan, Jing Wang, Xin-Ming Jia
Summary: Programmed death ligand 1 (PD-L1) regulates chemokine secretion to control neutrophil mobilization during Candida albicans infection. PD-L1 expression leads to neutrophil accumulation in bone marrow, enhancing host resistance to the infection. Blocking PD-L1 can enhance neutrophil release and improve host antifungal immunity.
NATURE COMMUNICATIONS
(2022)