期刊
NATURE MEDICINE
卷 17, 期 3, 页码 246-248出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm0311-246
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资金
- Grants-in-Aid for Scientific Research [20229008] Funding Source: KAKEN
X-box-binding protein-1 (XBP-1) increases insulin sensitivity by activating endoplasmic reticulum capacity during feeding to control glucose homeostasis, a function severely impaired in obesity. But XBP-1 can also increase glucose tolerance in obese and diabetic mice by blocking gluconeogenesis, independent of its effect on insulin sensitivity, opening new avenues for type 2 diabetes therapies (pages 356-365).
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