Article
Multidisciplinary Sciences
Katsutoshi Sato, Amol A. Padgaonkar, Stacey J. Baker, Stephen C. Cosenza, Olga Rechkoblit, D. R. C. Venkata Subbaiah, Josep Domingo-Domenech, Alison Bartkowski, Elisa R. Port, Aneel K. Aggarwal, M. V. Ramana Reddy, Hanna Y. Irie, E. Premkumar Reddy
Summary: Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinase inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Brandt C. Huddle, Edward Grimley, Mikhail Chtcherbinine, Cameron D. Buchman, Cyrus Takahashi, Bikash Debnath, Stacy C. McGonigal, Shuai Mao, Siwei Li, Jeremy Felton, Shu Pan, Bo Wen, Duxin Sun, Nouri Neamati, Ronald J. Buckanovich, Thomas D. Hurley, Scott D. Larsen
Summary: Research continues to develop pan-ALDH1A inhibitors to examine their effectiveness in combating chemotherapy-resistant ovarian cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Georgia-Persephoni Voulgaridou, Vasileios Theologidis, Vasileios Xanthis, Eleni Papagiannaki, Ilias Tsochantaridis, Vasiliki E. Fadouloglou, Aglaia Pappa
Summary: ALDH3A1 plays an important role in detoxification and antioxidant defense, and also has various functions in cell proliferation, cell cycle regulation, and DNA damage response. A peptide (P1) that interacts with ALDH3A1 was identified and shown to inhibit its activity. Potential protein candidates that may interact with hALDH3A1 were also suggested. This study identifies a novel peptide with potential biomedical applications and suggests potential protein candidates for future research on hALDH3A1 interactions.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Neurosciences
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim
Summary: Nociceptive signals modulate the mesolimbic reward system, possibly through the involvement of the lateral hypothalamus (LH) and lateral habenula (LHb). Stimulation by tail pinch excites LHb and LH neurons, leading to increased inhibitory activity on the mesolimbic dopamine (DA) system. This inhibition is essential for attenuating cocaine-induced behaviors and drug reinstatement.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Oncology
Chien-shan Cheng, Hor-Yue Tan, Ning Wang, Lianyu Chen, Zhiqiang Meng, Zhen Chen, Yibin Feng
Summary: LDHA is overexpressed in PAAD and associated with poor clinical outcomes. Genetic manipulation of LDHA promoted invasion and metastasis in PAAD, while berberine, an LDHA inhibitor, suppressed tumor progression in vitro and in vivo. The study suggests that LDHA may serve as a novel biomarker and potential therapeutic target for human PAAD.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
James R. Melchior, Rafael E. Perez, Gregory J. Salimando, Joseph R. Luchsinger, Aakash Basu, Danny G. Winder
Summary: This study reveals a dopamine-mediated cellular inhibition mechanism in the dBNST, suggesting that dopamine terminal autoreceptor activation and dopamine transporter blockade can affect the duration of catecholamine signals. Furthermore, cocaine enhances cellular inhibition in the dBNST in a drug reinforcement paradigm.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Tao Liu, Jiane Zuo, Zhiqiang Shen, Yuexi Zhou
Summary: The study found that crotonaldehyde had a 50% effect concentration (EC50) on the specific acidogenic activity (SAA) of 204.17 mg/L before 24 hours, with the inhibitory effect being removed after 48 hours when the crotonaldehyde dosage was less than 1000 mg/L. Crotonaldehyde was either completely reduced to crotonyl alcohol by nicotinamide adenine dinucleotide (NADH) or oxidized to (E)-crotonic acid by aldehyde dehydrogenase (DHO) after 48 hours. Clostridium_sensu_stricto_1, Clostridium_sensu_stricto_11, Clostridium_sensu_stricto_12 were the dominant bacterial communities related to the biodegradation process of crotonaldehyde.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Oncology
Ying Bai, Xuye Wang, Mengsi Cai, Chunbo Ma, Youqun Xiang, Wanle Hu, Bin Zhou, Chengguang Zhao, Xuanxuan Dai, Xiaokun Li, Haiyang Zhao
Summary: Cinobufagin, a natural product extracted from toad venom, exhibits high antitumor activity by inhibiting proliferation, migration, invasion, and promoting apoptosis of colorectal cancer cells in vitro and in vivo. The underlying mechanism involves suppression of the STAT3 pathway, leading to inhibition of epithelial-mesenchymal transition.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Behavioral Sciences
E. Theresa Bjorness, W. Robert Greene
Summary: Dopamine, orexin, and adenosine systems play dual roles in reward and sleep/arousal. Drug abuse may influence both reward and sleep/arousal mechanisms. Cocaine can cause acute sleep loss and abnormal recovery patterns under chronic exposure conditions. Experimentally induced sleep disturbance may increase cocaine seeking behavior.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Seungju Kim, Eun Young Jang, Sang-Hoon Song, Ji Sun Kim, In Soo Ryu, Chul-Ho Jeong, Sooyeun Lee
Summary: The study showed that inhibition of ALDH2 can protect against MA-induced hyperlocomotion and has therapeutic potential in the treatment of MA addiction.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Sumbul Ahmad, Abdullah Arsalan, Amiruddin Hashmi, Masood Alam Khan, Waseem Ahmad Siddiqui, Hina Younus
Summary: This study reveals that phthalate plasticizers can inhibit human salivary aldehyde dehydrogenase (hsALDH), increasing the risk of aldehyde-induced toxicity and leading to structural changes in the enzyme.
Article
Pharmacology & Pharmacy
Dehua Yu, Simin Qi, Xiaoqing Guan, Wenkai Yu, Xuefei Yu, Maohua Cai, Qinglin Li, Weiyi Wang, Weidong Zhang, Jiang-Jiang Qin
Summary: In this study, the marine-derived natural product terphenyllin was identified to directly interact with STAT3 and exhibit potent anticancer efficacy against gastric cancer through inhibiting the STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Dakota B. Zinani, Hanna N. Wetzel, Andrew B. Norman
Summary: This study revealed significant differences in the intake rate, satiety threshold, and half-life of different DAT inhibitors in rats. The duration of lever-pressing following termination of drug access was correlated with the t(1/2) estimates, suggesting a relationship between the time needed for animals to stop lever pressing and the PK properties of the agonist.
Article
Oncology
Seo Jin Kim, Soo Jeong Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Jieun Seon, Ran Joo Choi, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Eui Kyo Seo, Sun Ho Kim, Hyun Sil Kim, Wan-Yee Teo, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Summary: The study evaluated the therapeutic effects and underlying mechanisms of dual inhibition of CPT1A and G6PD in GBM, and found that this treatment approach effectively suppressed tumor growth and invasion, and extended survival in GBM mice models.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Neurosciences
Michal Wilczkowski, Karolina Karwowska, Michal Kielbinski, Katarzyna Zajda, Kamil Pradel, Gniewosz Drwiega, Zenon Rajfur, Tomasz Blasiak, Ryszard Przewlocki, Wojciech B. B. Solecki
Summary: This study demonstrates that recruiting specific inhibitory pathways can reduce drug seeking behavior, providing potential new targets for non-pharmacological treatment of drug craving.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Instruments & Instrumentation
Yijun Qiao, Hua Zhou, Zhang Jiang, Qiming He, Shenglong Gan, Hongdong Wang, Shizhu Wen, Juan de Pablo, Yuhong Liu, Matthew V. Tirrell, Wei Chen
REVIEW OF SCIENTIFIC INSTRUMENTS
(2020)
Article
Multidisciplinary Sciences
Zhang Jiang, Joseph W. Strzalka, Donald A. Walko, Jin Wang
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Bin Sun, Andrew Johnston, Chao Xu, Mingyang Wei, Ziru Huang, Zhang Jiang, Hua Zhou, Yajun Gao, Yitong Dong, Olivier Ouellette, Xiaopeng Zheng, Jiakai Liu, Min-Jae Choi, Yuan Gao, Se-Woong Baek, Frederic Laquai, Osman M. Bakr, Dayan Ban, Oleksandr Voznyy, F. Pelayo Garcia de Arquer, Edward H. Sargent
Article
Crystallography
Yue Cao, Dina Sheyfer, Zhang Jiang, Siddharth Maddali, Hoydoo You, Bi-Xia Wang, Zuo-Guang Ye, Eric M. Dufresne, Hua Zhou, G. Brian Stephenson, Stephan O. Hruszkewycz
Review
Physics, Applied
Zhang Jiang, Byeongdu Lee
Summary: Small-angle x-ray scattering is a technique used for determining the structure of superlattices, offering superior resolution, nondestructive properties, and high penetration power of x rays. Recent advancements in high brilliance x-ray sources and innovative computing algorithms have significantly improved the analysis of superlattices using SAXS, leading to high-resolution solutions for nanoscale structures.
APPLIED PHYSICS REVIEWS
(2021)
Article
Physics, Applied
Jong Woo Kim, Mathew J. Cherukara, Ashish Tripathi, Zhang Jiang, Jin Wang
Summary: Coherent surface scattering imaging requires a mathematical conversion to visualize specimen structures, which can now be predicted using a deep learning neural network model to instantly obtain results from scattering patterns. This is highly beneficial for both experimental effectiveness and data analysis.
APPLIED PHYSICS LETTERS
(2021)
Article
Instruments & Instrumentation
Zhang Jiang, Jin Wang, Matthew Tirrell, Juan J. de Pablo, Wei Chen
Summary: This article discusses the application of Bayesian inference-based methods in X-ray scattering analysis, focusing on the Hamiltonian MCMC method and its advantages.
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Physiology
Lauren E. Hood, Erin K. Nagy, Jonna M. Leyrer-Jackson, M. Foster Olive
Summary: Ethanol intake activates a subset of POMC neurons in the arcuate nucleus, while saccharin or water intake activates fewer of these neurons. These findings indicate a preferential activation of specific neurons by ethanol consumption, supporting the notion that ethanol activates endogenous opioid systems in the brain.
PHYSIOLOGICAL REPORTS
(2022)
Article
Instruments & Instrumentation
Miaoqi Chu, Jeffrey Li, Qingteng Zhang, Zhang Jiang, Eric M. Dufresne, Alec Sandy, Suresh Narayanan, Nicholas Schwarz
Summary: pyXPCSviewer is a Python-based graphical user interface that allows for interactive visualization of XPCS results. It parses complex XPCS data and generates interactive PyQt widgets for easy maintenance. The tool is open-source and customizable, catering to the diverse data structures and evolving techniques in the XPCS community.
JOURNAL OF SYNCHROTRON RADIATION
(2022)
Article
Optics
Peco Myint, Miaoqi Chu, Ashish Tripathi, Michael J. Wojcik, JIan Zhou, Mathew J. Cherukara, Suresh Narayanan, Jin Wang, Zhang Jiang
Summary: Surface-sensitive reflection-geometry scattering techniques, such as grazing incident small angle X-ray scattering, are commonly used to study nanostructures on substrates and provide statistical structural information. Coherent surface scattering imaging (CSSI) is a powerful yet non-invasive technique that can probe the absolute three-dimensional structural morphology of the sample. However, conventional CDI reconstruction techniques cannot be directly applied to CSSI due to the dynamical scattering phenomenon near the critical angle of total external reflection. To overcome this, a multislice forward model was developed to simulate the dynamical scattering from surface structures and the underlying substrate, enabling the reconstruction of an elongated 3D pattern from a single shot scattering image in CSSI geometry.
Editorial Material
Neurosciences
Amanda M. Acuna, M. Foster Olive
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Miaoqi Chu, Zhang Jiang, Michael Wojcik, Tao Sun, Michael Sprung, Jin Wang
Summary: By using multibeam scattering, it is possible to visualize three-dimensional structures of surface-supported and buried planar mesoscale structures in a single view. This method allows for high-resolution imaging of nanoelectronics, quantum dots, photovoltaics, and catalysts, and accurately reproduces complex scattering and surface features.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Hsin-Hsiang Huang, Zhiyuan Ma, Joseph Strzalka, Yang Ren, King-Fu Lin, Leeyih Wang, Hua Zhou, Zhang Jiang, Wei Chen
Summary: Moderate water content enhances the texture orientation of perovskite while guided water-incorporated treatment leads to excellent stability in unencapsulated devices, retaining over 80% of peak power-conversion efficiency after prolonged exposure to 1-sun illumination or heating at 65 degrees C for more than 1,000 hours.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Yin Fang, Endao Han, Xin-Xing Zhang, Yuanwen Jiang, Yiliang Lin, Jiuyun Shi, Jiangbo Wu, Lingyuan Meng, Xiang Gao, Philip J. Griffin, Xianghui Xiao, Hsiu-Ming Tsai, Hua Zhou, Xiaobing Zuo, Qing Zhang, Miaoqi Chu, Qingteng Zhang, Ya Gao, Leah K. Roth, Reiner Bleher, Zhiyuan Ma, Zhang Jiang, Jiping Yue, Chien-Min Kao, Chin-Tu Chen, Andrei Tokmakoff, Jin Wang, Heinrich M. Jaeger, Bozhi Tian
Article
Chemistry, Physical
Jing Yu, Jun Mao, Michihiro Nagao, Wei Bu, Binhua Lin, Kunlun Hong, Zhang Jiang, Yun Liu, Shuo Qian, Matthew Tirrell, Wei Chen