Human germinal center transcriptional programs are de-synchronized in B cell lymphoma

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

(2017) Hind Hashwah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma

(2017) Jiyuan Zhang et al.   Cancer Discovery

The many layers of epigenetic dysfunction in B-cell lymphomas

(2016) Yanwen Jiang et al.   CURRENT OPINION IN HEMATOLOGY

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

(2016) Yanwen Jiang et al.   Cancer Discovery

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

(2016) Robert Kridel et al.   PLOS MEDICINE

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

(2015) Monika S. Kowalczyk et al.   GENOME RESEARCH

Enhancer Sequence Variants and Transcription-Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B-Cell Lymphoma

(2015) Olivia I. Koues et al.   IMMUNITY

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

Class-switched memory B cells remodel BCRs within secondary germinal centers

(2015) Louise J McHeyzer-Williams et al.   NATURE IMMUNOLOGY

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

(2015) Jiyuan Zhang et al.   NATURE MEDICINE

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

(2015) Ana Ortega-Molina et al.   NATURE MEDICINE

Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions

(2015) Marc Seifert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation

(2015) Michael R. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell help controls the speed of the cell cycle in germinal center B cells

(2015) A. D. Gitlin et al.   SCIENCE

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution

(2015) Emanuela Carlotti et al.   PLoS One

Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?

(2014) J. Tellier et al.   BLOOD

Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression

(2014) Stéphanie Sungalee et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Genetics of Follicular Lymphoma Transformation

(2014) Laura Pasqualucci et al.   Cell Reports

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

(2013) Jessica Okosun et al.   NATURE GENETICS

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments

(2012) Andrew McDavid et al.   BIOINFORMATICS

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

(2012) G. D. Victora et al.   BLOOD

Pathogenesis of follicular lymphoma

(2012) Robert Kridel et al.   JOURNAL OF CLINICAL INVESTIGATION

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

(2012) David Dominguez-Sola et al.   NATURE IMMUNOLOGY

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

(2012) Dinis Pedro Calado et al.   NATURE IMMUNOLOGY

Stromal Cell Contribution to Human Follicular Lymphoma Pathogenesis

(2012) Frédéric Mourcin et al.   Frontiers in Immunology

Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells

(2011) P Amé-Thomas et al.   LEUKEMIA

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

The genetic network controlling plasma cell differentiation

(2011) Stephen L. Nutt et al.   SEMINARS IN IMMUNOLOGY

Optimizing transformations for automated, high throughput analysis of flow cytometry data

(2010) Greg Finak et al.   BMC BIOINFORMATICS

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses

(2010) J. P. Pereira et al.   INTERNATIONAL IMMUNOLOGY

Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent TFH–B cell axis

(2010) C Pangault et al.   LEUKEMIA

Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone

(2009) E. Carlotti et al.   BLOOD

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS