Review
Endocrinology & Metabolism
Karl Chan, F. Susan Wong, James Alexander Pearson
Summary: Type 2 diabetes mellitus, obesity, and metabolic syndrome are on the rise globally, posing challenges to healthcare systems. Research on circadian rhythms and metabolic diseases suggests that circadian disruption may contribute to metabolic abnormalities. Further investigation into circadian interventions may offer new insights into the management of metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Neurosciences
Bastien Lechat, Hannah Scott, Ganesh Naik, Kristy Hansen, Duc Phuc Nguyen, Andrew Vakulin, Peter Catcheside, Danny J. Eckert
Summary: Current approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise and laborious. Newer emerging approaches aim to overcome these constraints and better align diagnostic and treatment approaches to underlying pathology. This includes more advanced EEG signal feature detection and novel oxygenation metrics to capture hypoxia more accurately.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Yu Jiang, Nan Gen, Peisong Wang, Ninghang Feng, Xiaojie Lu
Summary: This study investigated the effects of prednisolone (PN) on sleep in zebrafish. The results showed that PN decreased melatonin secretion, shortened sleep time, and disrupted the internal circadian rhythm. The mechanism behind these effects involves the repression of certain genes via the glucocorticoid receptor, leading to a decrease in melatonin secretion and subsequent sleep disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Robin K. Yuan, Kirsi-Marja Zitting, Jeanne F. Duffy, Nina Vujovic, Wei Wang, Stuart F. Quan, Elizabeth B. Klerman, Frank A. J. L. Scheer, Orfeu M. Buxton, Jonathan S. Williams, Charles A. Czeisler
Summary: Insufficient sleep and circadian disruption can affect metabolism, with research showing that sleep restriction may impact metabolism through concurrent circadian disruption. When circadian disruption is minimized, the adverse effects of insufficient sleep on glycemic control may be attenuated.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Mario Henriquez-Beltran, Ivan Benitez, Thalia Belmonte, Jorge Jorquera, Jorge Jorquera-Diaz, Igor Cigarroa, Matias Burgos, Rocio Sanhueza, Claudia Jeria, Isabel Fernandez-Bussy, Estefania Nova-Lamperti, Ferran Barbe, Adriano Targa, Gonzalo Labarca
Summary: This study evaluates the impact of ARDS on sleep and circadian rest-activity rhythm of COVID-19 survivors twelve months after hospital discharge. The findings show that the majority of survivors had poor sleep quality and a high prevalence of sleep disorders after twelve months. However, there was no significant improvement in sleep or circadian rest-activity rhythm between four and twelve months, or between the ARDS and non-ARDS groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Wen-jing Liu, Jie-yu Chen, Si-ru Niu, Yi-sha Zheng, Shu Lin, Yu Hong
Summary: This study examines the relationship between circadian rhythm disorders, diabetes, and diabetic retinopathy (DR). The findings suggest that abnormal functioning of the central and peripheral clocks can lead to abnormal glucose metabolism, further exacerbating the development of DR. This study provides new insights into the prevention and treatment of DR.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Genetics & Heredity
Chaoran Liu, Xiangrong Tang, Zishan Gong, Wang Zeng, Qiao Hou, Renbin Lu
Summary: Nearly all living organisms have an internal circadian oscillation with a periodicity of approximately 24 hours. Misalignment between circadian rhythms and external environment can lead to circadian rhythm sleep disorders (CRSD), which have been found to be associated with adverse health consequences. Recent studies have made progress in understanding the genetic basis and pathological mechanisms of CRSD, particularly in advanced sleep-wake phase disorder (ASPD) and delayed sleep-wake phase disorder (DSPD).
FRONTIERS IN GENETICS
(2022)
Review
Dermatology
Usamah M. Afzal, Faisal R. Ali
Summary: Sleep is often overlooked when assessing patients with cutaneous disease, leading to a lack of consideration for the relationship between sleep deprivation and disease burden. Our review article aims to explore the bidirectional relationship between sleep and cutaneous disease by investigating the disruption in circadian rhythmicity and skin homeostasis. Management strategies should focus on optimizing disease control and improving sleep hygiene.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sandra Haupt, Max L. Eckstein, Alina Wolf, Rebecca T. Zimmer, Nadine B. Wachsmuth, Othmar Moser
Summary: The circadian rhythmicity of endogenous metabolic and hormonal processes is crucial for overall health. Adjusting the timing of diet and exercise can help reset disrupted circadian pacemakers and potentially prevent metabolic diseases. However, these lifestyle interventions cannot address the underlying issue of the misalignment between our biological and social time.
Article
Agriculture, Multidisciplinary
Shufen Han, Hui Gao, Ruijuan Song, Weiguo Zhang, Yuezhen Li, Jie Zhang
Summary: Oat fiber can prevent obesity and dyslipidemia caused by a high-fat diet by restoring circadian oscillations; High-fat diet disrupts the hepatic circadian protein expressions, while oat fiber reverses these effects; SCFAs play a crucial role in regulating circadian rhythm and mediating the beneficial effects of oat fiber.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Neurosciences
Srishti Banerjee, Sandipan Ray
Summary: Aging leads to deterioration of daily rhythms and disruption in sleep-wake cycles. Mutations in core clock genes contribute to premature aging and sleep irregularities. Targeting the molecular clock or dosing time-oriented medications may provide novel therapeutic strategies for aging attenuation and sleep disorders.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Mehar Sahu, Rahul Tripathi, Niraj Kumar Jha, Saurabh Kumar Jha, Rashmi K. Ambasta, Pravir Kumar
Summary: Sleep disorders are becoming more prevalent among the elderly population, especially those with neurodegenerative and neuropsychiatric disorders. This article reviews the mechanisms and effects of sleep dysfunction in these disorders, including disturbed circadian rhythm, gene regulation, brainwave perturbations, and ocular manifestations. Non-pharmacological treatments are gaining importance due to the limitations of pharmacological approaches.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
Lucia Pinilla, Ivan D. Benitez, Esther Gracia-Lavedan, Gerard Torres, Olga Minguez, Maria Aguila, Adriano Targa, Mireia Dalmases, Olga Mediano, Juan F. Masa, Maria J. Masdeu, Ferran Barbe, Manuel Sanchez-de-la-Torre
Summary: This study aimed to identify the main contributors to explain the nondipper profile in obstructive sleep apnea (OSA) by characterizing the polysomnography (PSG) parameters associated with alterations in the circadian blood pressure (BP) pattern.
Article
Clinical Neurology
Luiz Antonio Alves de Menezes Junior, Virginia Capistrano Fajardo, Silvia Nascimento de Freitas, George Luiz Lins Machado-Coelho, Fernando Luiz Pereira de Oliveira, Raimundo Marques do Nascimento Neto, Adriana Lucia Meireles
Summary: This study evaluated the association between obstructive sleep apnea (OSA) and vitamin D deficiency (VDD) in shift workers. The results showed that shift workers with VDD are more likely to have OSA.
SLEEP AND BREATHING
(2023)
Review
Clinical Neurology
Tyler A. Steele, Erik K. St Louis, Aleksandar Videnovic, R. Robert Auger
Summary: Circadian rhythms play a crucial role in various physiological processes and daily life activities. Different circadian sleep-wake disorders require specific management strategies, such as light therapy, melatonin, and other pharmacological treatments.
Article
Hospitality, Leisure, Sport & Tourism
Lei Gao, Arlen Gaba, Peng Li, Richa Saxena, Frank A. J. L. Scheer, Oluwaseun Akeju, Martin K. Rutter, Kun Hu
Summary: This study found that the heart rate recovery (HRR) during exercise is associated with future risk for delirium in middle-to older-aged individuals. Those with lower HRR have a higher risk for developing delirium.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Endocrinology & Metabolism
Andrew W. McHill, Lindsey S. Brown, Andrew J. K. Phillips, Laura K. Barger, Marta Garaulet, Frank A. J. L. Scheer, Elizabeth B. Klerman
Summary: This study examined the relationship between the timing of energy intake and body composition based on mathematically modeled circadian timing and in-laboratory collected metrics. The findings suggest that the use of mathematically modeled circadian timing can provide similar results to in-laboratory measurements, which may be beneficial in time-based interventions.
Article
Endocrinology & Metabolism
Deanna M. Arble, Chelsea R. Hutch, Hannah Hafner, Daria Stelmak, Kyle Leix, Joyce Sorrell, Joshua W. Pressler, Brigid Gregg, Darleen A. Sandoval
Summary: We investigated the impact of Gcg on b-cell function and its response to STZ-induced hyperglycemia. GcgNull mice showed decreased glucose-stimulated insulin secretion, increased b-cell mass, and partial protection against STZ-induced hyperglycemia. Pancreatic expression of Gcg normalized these effects, while intestinal expression of Gcg only restored b-cell mass and glucose-stimulated insulin secretion. The increased b-cell mass in GcgNull mice compensated for reduced insulin secretion, normalizing physiological glucose levels and providing some protection after STZ-induced diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Critical Care Medicine
Jaejin An, Henry A. Glick, Amy M. Sawyer, Jessica Arguelles, Charles J. Bae, Brendan T. Keenan, Samuel T. Kuna, Greg Maislin, Diego R. Mazzotti, Allan I. Pack, Jiaxiao M. Shi, Alexa J. Watach, Dennis Hwang
Summary: This study investigated the association between adherence to positive airway pressure (PAP) therapy and healthcare costs in participants with obstructive sleep apnea (OSA) over a 3-year period. The results showed that higher adherence to PAP therapy was associated with significantly lower healthcare costs.
Article
Clinical Neurology
Lei Gao, Peng Li, Nicole Gaykova, Xi Zheng, Chenlu Gao, Jacqueline M. Lane, Richa Saxena, Frank A. J. L. Scheer, Martin K. Rutter, Oluwaseun Akeju, Kun Hu
Summary: This study found a bidirectional link between delirium and dementia, suggesting that they may be mutually related. Furthermore, disturbances in the sleep-wake rhythm were associated with an increased risk of delirium and progression to dementia. These findings highlight the importance of sleep-wake rhythm in cognitive function.
ANNALS OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Qian, Qian P. Xiao, Michael Walkup, Mace L. Coday, Melissa Erickson, Jessica M. Unick, John Jakicic, Kun Hu, Frank A. J. L. Scheer, Roeland J. W. Middelbeek, Look AHEAD Res Grp
Summary: This study aimed to determine the association of the time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control in adults with overweight/obesity and type 2 diabetes. The study found that bMVPA performed in the afternoon is associated with improvements in glycemic control, especially within the initial 12 months of an intervention.
Article
Endocrinology & Metabolism
Aviva Y. Cohn, Leilah K. Grant, Margo D. Nathan, Aleta Wiley, Mathena Abramson, Jessica A. Harder, Sybil Crawford, Elizabeth B. Klerman, Frank A. J. L. Scheer, Ursula B. Kaiser, Shadab A. Rahman, Hadine Joffe
Summary: This study investigated the effects of menopause-related sleep disturbance and estradiol decline on cortisol levels in healthy young women. The results showed that sleep fragmentation increased bedtime cortisol levels and decreased cortisol awakening response. Furthermore, suppression of estradiol also decreased bedtime cortisol levels. These findings suggest that menopause-related sleep disturbance and estradiol decline can negatively affect the activity of the hypothalamic-pituitary-adrenal axis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Marta Garaulet, Barbara Vizmanos, Teresa Muela, Alejandra Betancourt-Nunez, Maria-angeles Bonmati-Carrion, Celine Vetter, Hassan S. Dashti, Richa Saxena, Frank A. J. L. Scheer
Summary: This study aimed to investigate the relationship between being an evening type and reporting emotional eating behaviors. The results showed that evening types had higher scores on emotional eating and were more likely to be emotional eaters. They also scored higher on disinhibition/overeating and food craving factors. A meta-analysis revealed that being an evening type was associated with a higher score on emotional eating. Furthermore, individuals with late dim-light melatonin onset showed higher scores on emotional eating.
Article
Endocrinology & Metabolism
Barbara Vizmanos, Ana Isabel Cascales, Maria Rodriguez-Martin, Diego Salmeron, Eva Morales, Aurora Aragon-Alonso, Frank A. J. L. Scheer, Marta Garaulet
Summary: This study aimed to investigate the association between siestas and obesity, considering siesta duration and whether siesta traits and/or lifestyle factors mediate this association. The results showed that long siestas were associated with higher BMI, waist circumference, fasting glucose, blood pressure, and increased prevalence of MetS. However, short siestas were associated with a lower probability of elevated blood pressure. Various factors, including smoking, sleep and eating schedules, energy intake, and siesta location, mediated the association of siestas with obesity and MetS.
Article
Endocrinology & Metabolism
Gabriella M. Marino, Deanna M. Arble
Summary: Sleep and circadian disruption are linked to a higher risk of metabolic disease. Researchers propose that targeting groups of cells with functional relationships can provide a better understanding of the consequences of sleep and circadian disruption, especially for metabolic outcomes that involve multiple sites of action.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biology
Emma Grosjean, Valerie Simonneaux, Etienne Challet
Summary: Our daily life follows 24-hour cycles in various biological functions, such as sleep-wake and feeding/fasting cycles. These rhythms are regulated by endogenous clocks that are synchronized by environmental cues. Circadian disruption, such as exposure to bright light at night or nocturnal meals, can have detrimental effects on energy balance in humans, leading to increased metabolic risks. Chrononutritional strategies, considering factors such as regularity of daily meals and eating periods, can help improve daily rhythmicity and maintain appropriate energy balance.
Article
Neurosciences
Aaron A. Jones, Deanna M. Arble
Summary: Breathing in vertebrate animals is regulated by various factors, including metabolism, sleep-wake state, activity level, and endocrine signaling. Environmental light affects these factors, both indirectly by organizing daily and seasonal behaviors and directly through changes in neural signaling. However, the underlying mechanisms and clinical relevance of how light modulates breathing are not well understood. This article provides new evidence and discusses potential neurobiological mechanisms by which light influences respiratory behavior. The conclusion is that environmental light should be recognized as a clinically relevant modulator of respiratory health and disease, from bench to bedside.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Sport Sciences
Fabienne Bruggisser, Raphael Knaier, Ralf Roth, Wei Wang, Jingyi Qian, Frank A. J. L. Scheer
Summary: This systematic review and meta-analysis aimed to investigate whether the timing of exercise training in intervention studies affects the degree of improvements in physical performance or health-related outcomes. The results indicate that there is little evidence supporting the hypothesis that training at a specific time of day leads to more improvements compared to other times. However, there is some evidence that training and testing at the same time of day may have a benefit, particularly for performance-related outcomes.
SPORTS MEDICINE-OPEN
(2023)
Article
Chemistry, Organic
Chathuri J. Kombala, Neha Agrawal, Agne Sveistyte, Ilia N. Karatsoreos, Hans P. A. Van Dongen, Kristoffer R. Brandvold
Summary: The diurnal rhythmicity of cellular function is crucial for survival for most organisms. This study focuses on microbial bile salt biotransformation and develops a novel assay to detect bile salt hydrolase (BSH) activity in small quantities of stool samples. The study demonstrates the diurnal fluctuations of BSH activity in the large intestine of mice and its correlation with feeding patterns.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biology
H. Craig Heller, Erik Herzog, Allison Brager, Gina Poe, Ravi Allada, Frank Scheer, Mary Carskadon, Horacio O. de la Iglesia, Rockelle Jang, Ashley Montero, Kenneth Wright, Philippe Mouraine, Matthew P. Walker, Namni Goel, John Hogenesch, Russell N. Van Gelder, Lance Kriegsfeld, Cheri Mah, Christopher Colwell, Jamie Zeitzer, Michael Grandner, Chandra L. Jackson, J. Roxanne Prichard, Steve A. Kay, Ketema Paul
Summary: Collegiate athletes face various pressures, including academic obligations, performance impact, health issues, and extensive travel. East-west travel disrupts circadian rhythms and affects sleep quality and health. To address these concerns, we provide suggestions and steps such as bedtime protocols, afternoon naps, and adherence to lighting exposure protocols, and encourage collaboration between athletic departments and experts to promote the health and wellbeing of athletes and staff.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)