Article
Pharmacology & Pharmacy
Kojo Mensa-Wilmot
Summary: Many studies have found the incomplete identification of drug physiological targets, and proposed a multidisciplinary approach for systematically identifying drug targets in cells.
MOLECULAR PHARMACOLOGY
(2021)
Article
Computer Science, Software Engineering
Hanxiao Shen, Leyi Zhu, Ryan Capouellez, Daniele Panozzo, Marcel Campen, Denis Zorin
Summary: This paper describes a method for generating seamless surface parametrizations with guaranteed local injectivity and full control over holonomy. The ability to control holonomy is crucial for guiding isocurves based on directional information and topological constraints on the parametrization.
ACM TRANSACTIONS ON GRAPHICS
(2022)
Article
Multidisciplinary Sciences
Takashi Yamashita, Yusuke Takanashi, Asuka Uebayashi, Mikako Oka, Kiyomichi Mizuno, Akikazu Kawase, Soho Oyama, Takuya Kitamoto, Minako Kondo, Shiho Omori, Hong Tao, Yutaka Takahashi, Takumi Sakamoto, Tomoaki Kahyo, Haruhiko Sugimura, Mitsutoshi Setou, Norihiko Shiiya, Kazuhito Funai
Summary: In patients with unresectable non-small cell lung cancer, a novel diagnostic method independent of tissue morphology or conventional immunohistochemistry (IHC) markers is required. This study analyzed the lipid profiles of resected primary lung adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) specimens and identified novel candidate lipid markers with high diagnostic abilities for ADC and SQCC. These lipid markers may contribute to a more accurate diagnosis and subsequent treatment strategy for unresectable NSCLC.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Experimental
Jongmin Lee, Koeun Jung, Suk Won Han
Summary: Researchers debate whether people find a target among multiple stimuli through serial or parallel processing. Recent theories suggest that visual search tasks involve both serial and parallel processes. Through experimentation, specific behavioral patterns associated with serial and self-terminating search were identified, shedding light on the conditions under which search becomes more serial or parallel. Multiple recent models of visual search are discussed to accommodate these findings and reconcile the existing controversy.
Article
Multidisciplinary Sciences
Timo Eninger, Stephan A. Mueller, Mehtap Bacioglu, Manuel Schweighauser, Marius Lambert, Luis F. Maia, Jonas J. Neher, Sarah M. Hornfeck, Ulrike Obermueller, Gernot Kleinberger, Christian Haass, Philipp J. Kahle, Matthias Staufenbiel, Lingyan Ping, Duc M. Duong, Allan Levey, Nicholas T. Seyfried, Stefan F. Lichtenthaler, Mathias Jucker, Stephan A. Kaeser
Summary: Single-cell transcriptomics has revealed glial activation states associated with neurodegenerative diseases, but little is known about biomarker changes in bodily fluids. This study explored proteomic changes in cerebrospinal fluid related to proteopathic lesions in mouse models and found increased glial-derived proteins that could also be detected in human cerebrospinal fluid, supporting efforts to identify fluid biomarkers for neurodegenerative diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
George Samrani, Jonas Persson
Summary: This study used fMRI to investigate the boundary conditions of proactive interference in working memory. The results showed that proactive interference was present when the lure was close in proximity but dissipated with distance. Repeated item presentation and rehearsed encoding of item-context information reduced the interference control. Additionally, there was increased activation in various brain regions when facing increasing lure trial interference.
Article
Biochemistry & Molecular Biology
Ke Ma, Jin-Feng Liu, Zi-Run Zheng, Hong-Yue Li, Bo Hu, Yu Meng
Summary: Macrophages play a significant role in acute kidney injury in sepsis patients, but their specific role is still unclear. This study found that polarization of M2 macrophages after methylprednisolone injection can significantly alleviate acute kidney injury.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Pharmacology & Pharmacy
Federico Marquez, Mariana Lozada, Yanina L. Idaszkin, Rolando Gonzalez-Jose, Gregorio Bigatti
Summary: Achene shape variation is a potential biomarker of cannabinoid content in Cannabis varieties, with differences observed between chemotypes. Further research is needed to confirm the use of geometric morphometrics for high-throughput screening of Cannabis cultivars, considering a wider diversity of varieties and growth conditions.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Orthopedics
Thomas Michael Zahradnik, Mark Cresswell, Kip Squier, Charlotte Waugh, Liam Brunham, Hazel Screen, Alex Scott
Summary: Analysis of separated fat and water magnetic resonance images can differentiate between xanthomatic and nonxanthomatic Achilles tendons. Xanthomas in Achilles tendons demonstrate greater lipid content compared to tendinopathy or healthy tendons. Ultrasound tissue characterization reveals worse tissue organization and greater thickness in Achilles tendon xanthomas.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Medicine, Research & Experimental
Xichen Wang, Benson O. A. Botchway, Yong Zhang, Min Huang, Xuehong Liu
Summary: Nerve injury has detrimental effects on human motor and sensory function, disrupting nerve structure integrity. Activation of glial cells and disruption of synaptic integrity lead to inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid derivative, has shown beneficial effects in various animal models of nerve injury. This review summarizes the anti-inflammatory, neuroprotective, and pain hypersensitivity effects of maresin1 and provides the theoretical basis for its clinical application in treating nerve injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physics, Multidisciplinary
Hayato Arai, Masahito Hayashi
Summary: An experimental verification ensures that the constructed state is close to, but not exactly the same as, the maximally entangled state. The existence of the maximally entangled state depends on the validity of the standard entanglement structure (SES). Surprisingly, there are infinitely many pseudo SESs different from the SES, but these pseudo structures never possess global unitary symmetry, which is an essential condition for the SES.
NEW JOURNAL OF PHYSICS
(2023)
Article
Pharmacology & Pharmacy
John Shelestak, Muhammad Irfan, Tara M. DeSilva
Summary: Multiple sclerosis (MS) is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). While immunomodulatory therapies are effective in reducing relapses, there is a lack of treatment for progressive disease. Chronic demyelination leads to axonal injury and loss, contributing to neurodegeneration and permanent disability in MS. Recent research has shown the potential of oligodendrocyte progenitor cells (OPCs) in remyelination to protect axons and preserve neuronal function. Understanding the role of microglia in myelin development can provide insights for remyelination strategies.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Review
Immunology
Michal A. Rahat
Summary: Solid tumors metastasize early in their development through a process called the metastatic cascade, which involves detachment, migration, intravasation, extravasation, adhesion, and outgrowth of tumor cells. The interactions between tumor cells and immune cells, particularly macrophages, play a critical role in driving the metastatic cascade. CD147/EMMPRIN is a molecule that is involved in all steps of the process and targeting it can block metastasis and prevent tumor recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Lukas Ernstbrunner, Rany El Nashar, Philippe Favre, Samy Bouaicha, Karl Wieser, Christian Gerber
Summary: The study analyzed structural and biomechanical differences between patients with chronic pseudoparalysis and those with chronic pseudoparesis, revealing distinct imaging characteristics and tear extension differences.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Microbiology
Wanzhu Li, Baoli Wang, Jing Xiao, Meiling Yang, Sheng Xu, Cong-Qiang Liu
Summary: This study reveals the importance of photosynthetic light energy utilization in controlling phytoplankton cell size. The results show that there is a positive relationship between F-v/F-m and cell volume, indicating the role of energy and matter in shaping phytoplankton size. The molecular mechanisms behind this control have been identified, providing valuable insights into the understanding of cell size control in phytoplankton.
FRONTIERS IN MICROBIOLOGY
(2022)