Review
Ecology
Rishi V. Shridharan, Neha Kalakuntla, Narendra Chirmule, Bhavana Tiwari
Summary: Nearly 50% of the human genome is derived from transposable elements, some of which can cause diseases when dysregulated, while others can generate new cellular functions. The adaptive immune system in jawed vertebrates is associated with Class II TEs, and the somatic rearrangement process in T and B cells is also influenced by TEs, laying the foundation for the generation of antibodies and receptors.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Endocrinology & Metabolism
Nerea Deleyto-Seldas, Alejo Efeyan
Summary: Dai and colleagues demonstrate that glucose starvation stimulates AMPK activation, which in turn phosphorylates GATOR2 and influences nutrient-dependent activation of mTORC1.
Article
Biochemistry & Molecular Biology
Tetsuya Kimura, Yoshitomo Hayama, Daisuke Okuzaki, Shigeyuki Nada, Masato Okada
Summary: mTORC1 signaling pathway plays a crucial role in regulating cellular responses. This study demonstrates that Ragulator complex is essential for inhibiting the nuclear translocation of TFEB, and mTORC1 requires Ragulator for regulating the subcellular distribution of TFEB.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Yuto Kuwasaki, Kazushi Suzuki, Gaigai Yu, Shota Yamamoto, Takahiro Otabe, Yuki Kakihara, Michiru Nishiwaki, Keita Miyake, Keiji Fushimi, Ramsey Bekdash, Yoshihiro Shimizu, Rei Narikawa, Takahiro Nakajima, Masayuki Yazawa, Moritoshi Sato
Summary: This study developed a red light-activatable photoswitch called MagRed, which incorporates a red light-absorbing bacterial phytochrome, a mammalian endogenous chromophore, biliverdin, and a photo-state-specific binder. Using MagRed, a red light-activatable Cre recombinase and red light-inducible transcriptional regulators based on CRISPR-Cas9 were developed, enabling optical control of genetic manipulations in deep mammalian tissues.
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jie Chen, Yuhui Ou, Rong Luo, Jie Wang, Dong Wang, Jialiang Guan, Yi Li, Peixue Xia, Peng R. Chen, Ying Liu
Summary: SAR1B is a conserved leucine sensor involved in regulating mTORC1 signaling, which controls cell growth and potentially plays a role in the development of lung cancer.
Article
Multidisciplinary Sciences
Lukas Theo Schmitt, Maciej Paszkowski-Rogacz, Florian Jug, Frank Buchholz
Summary: The authors present RecGen, an algorithm for generating designer-recombinases, which was experimentally validated to predict recombinase sequences. This algorithm can accelerate the development of future designer-recombinases, providing a significant contribution to genome engineering.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Helene Duplus-Bottin, Martin Spichty, Gerard Triqueneaux, Christophe Place, Philippe Emmanuel Mangeot, Theophile Ohlmann, Franck Vittoz, Gael Yvert
Summary: LiCre is a novel light-inducible Cre recombinase, capable of being activated within minutes by blue light with faster and stronger activation effects and lower residual activity in the dark. It shows high efficiency in both yeast and human cells, making it suitable for fundamental research, biomedical research, and industrial bioprocess control.
Article
Biochemistry & Molecular Biology
Meiling Lu, Lei Yu, Yanrong Yang, Jiali Zhu, Sujing Qiang, Xinbo Wang, Jia Wang, Xiao Tan, Weifeng Wang, Yue Zhang, Weichao Wang, Jian Xie, Xinyan Chen, Hongbing Wang, Xianghuan Cui, Xin Ge
Summary: The study identifies hayatine as a potential mTORC1 inhibitor with unique properties that can suppress cancer cell growth through various mechanisms, offering promise in overcoming rapamycin resistance for cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Computer Science, Artificial Intelligence
Liangrui Ren, Guoxian Yu, Jun Wang, Lei Liu, Carlotta Domeniconi, Xiangliang Zhang
Summary: This paper proposes a method named iMClusts that uses deep autoencoders and multi-head attention to generate multiple salient embedding matrices and clusterings. It enhances the quality and diversity of clusterings by leveraging multi-facet knowledge.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2023)
Article
Medicine, Research & Experimental
Na Yin, Gang Jin, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng
Summary: This study demonstrates the critical role of nutrient mTORC1 signaling in maintaining hematopoietic stem cell (HSC) homeostasis. Loss of the mTORC1 regulators SZT2 and TSC1 leads to rapid HSC depletion and the synergistic effect of these losses significantly increases mTORC1 activity and ROS production, further depleting HSCs.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Computer Science, Information Systems
Fengyang Sun, Lin Wang, Bo Yang
Summary: The study introduces a novel framework for comprehensively assessing evolutionary algorithms in a black box scenario by randomly generating diversified benchmark functions. Experimental results demonstrate significant differences in performance among optimizers tested on the proposed problems compared to well-known BBOB and CEC problems, emphasizing the necessity of the proposed benchmarks for facilitating a more comprehensive evaluation.
INFORMATION SCIENCES
(2021)
Article
Engineering, Biomedical
Elizabeth M. M. Cosgriff-Hernandez, Brian A. A. Aguado, Belinda Akpa, Gabriella Coloyan Fleming, Erika Moore, Ana Maria Porras, Patrick M. M. Boyle, Deva D. D. Chan, Naomi Chesler, Karen L. L. Christman, Tejal A. A. Desai, Brendan A. C. Harley, Gregory A. A. Hudalla, Megan L. L. Killian, Katharina Maisel, Kristen C. C. Maitland, Shelly R. R. Peyton, Beth L. L. Pruitt, Sarah E. E. Stabenfeldt, Kelly R. R. Stevens, Audrey K. K. Bowden
Summary: We offer a roadmap for revamping faculty hiring processes to remove barriers that have historically excluded certain groups.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Information Systems
Chenkai Guo, Weijie Zhang, Naipeng Dong, Zheli Liu, Yang Xiang
Summary: In this work, a novel diversity-aware graph-based QoS prediction model-DSSN is proposed to address the problem of selection redundancy in QoS-aware service selection. Techniques like high-order message propagation and multi-task structure are integrated to enhance the model performance, and a service distance based attention mechanism is designed to enhance service diversity. The evaluation experiments demonstrate that DSSN outperforms existing diversity-aware models in terms of accuracy and diversity, making it more suitable for diversity-aware service selection.
IEEE TRANSACTIONS ON SERVICES COMPUTING
(2023)
Review
Immunology
Chen Chen, Aibao Chen, Yanan Yang
Summary: Vector-borne diseases pose major health threats globally, and γδT cells play a crucial role in regulating host-pathogen interactions and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Computer Science, Interdisciplinary Applications
Surbhi Gupta, Gaurav Singal, Deepak Garg
Summary: There have been significant advancements in deep learning and reinforcement learning techniques, particularly in the fusion of these two areas known as Deep Reinforcement Learning (DRL). Despite successes in various domains, challenges such as generalization, meeting multiple objectives, divergence, and learning robust policies still persist. Researchers are currently focusing on improving the recording of experiences and refining policies for future actions to address these challenges.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2021)