Review
Biochemistry & Molecular Biology
Yin Huang, Dan Li, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang, Kun Tang, Stefan Grunewald
Summary: This study conducted a genome-wide association study on the genetic basis of facial morphology in the Han Chinese population, identifying significant associations between multiple facial features and different genomic regions. These findings contribute to a more comprehensive understanding of the genetic factors underlying variation in human facial morphology.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Meng Zhu, Jingyi Fan, Chang Zhang, Jing Xu, Rong Yin, Erbao Zhang, Yuzhuo Wang, Mengmeng Ji, Qi Sun, Juncheng Dai, Guangfu Jin, Liang Chen, Lin Xu, Zhibin Hu, Hongxia Ma, Hongbing Shen
Summary: This study conducted a cross-tissue transcriptome-wide association study using UTMOST, identifying 6 known susceptibility genes and 12 novel ones for lung cancer susceptibility. Among these, 5 novel genes were significantly associated with lung cancer risk in both cross-tissue and lung tissue models. Further analysis indicated that specific genetic variants drove the GWAS association signals and influenced the expression of certain genes in lung tissue, supporting their role in lung carcinogenesis.
HUMAN MOLECULAR GENETICS
(2021)
Article
Multidisciplinary Sciences
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Summary: Prognostication in CLL patients is challenging due to its heterogeneous clinical course. This study identifies two genomic locations associated with disease progression, highlighting the impact of constitutional genetic variation on CLL prognosis. Additionally, functional genes implicated in modulating key pathways in CLL pathogenesis are identified.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellstrom, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Voelker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguez-Manas, Francisco J. Garcia, Jose A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Summary: Low muscle strength is a heritable indicator of poor health in older people, with genetic loci associated with muscle weakness identified through genome-wide meta-analysis. Possible causal relationships with diabetes susceptibility, hematological parameters, and the immune system were also discovered using Mendelian randomization. The distinct mechanisms of muscle weakness from continuous strength were highlighted, shedding light on potential pathways involved in ageing.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Multidisciplinary Sciences
Ruidong Xiang, Iona M. MacLeod, Hans D. Daetwyler, Gerben de Jong, Erin O'Connor, Chris Schrooten, Amanda J. Chamberlain, Michael E. Goddard
Summary: This study presents a method for fine-mapping potentially causal mutations by integrating functional, evolutionary, and pleiotropic information and developing a custom genotyping array. The custom array, containing variants with biological functions, outperformed the standard array in predicting genetic values for multiple traits in dairy cattle populations across different countries. This highlights the potential improvement in genomic prediction by utilizing mutations with functional, evolutionary, and pleiotropic consequences.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Ammarah Ghaffar, Dale R. Nyholt
Summary: We developed a method named GIDEE to prioritize trait-relevant tissues by combining GWAS summary statistic data with tissue-specific eQTL data. The best-performing GIDEE method ranked the known trait-relevant tissue first multiple times across nine training datasets. Application of the GIDEE approach to test datasets provided important prioritization of tissues relevant to the trait's regulatory architecture.
FRONTIERS IN GENETICS
(2023)
Article
Andrology
Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jianbing Xu, Meng Yang, Shaowei Mo, Liying Zhuang, Liefu Ye, Weifu Wang
Summary: This study conducted a genome-wide association study on lifelong premature ejaculation (LPE) in the Chinese male Han population and identified 33 genetic polymorphisms associated with LPE risk. The findings provide data supplementation for the genetic loci of LPE risk and lay a scientific foundation for understanding the pathogenesis and targeted therapy of LPE.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Genetics & Heredity
Yafen Yu, Qi Zhen, Weiwei Chen, Yanqin Yu, Zhuo Li, Yirui Wang, Wencheng Fan, Sihan Luo, Daiyue Wang, Yuanming Bai, Zhuan Bian, Miao He, Liangdan Sun
Summary: In this study, genome-wide association studies and meta-analyses were conducted on a Chinese Han population to identify risk loci for nonsyndromic orofacial clefts. A total of 47 risk loci were identified, including 5 new loci, which collectively accounted for 44.12% of the heritability of orofacial clefts in the population.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Multidisciplinary Sciences
Laura J. Smyth, Emma H. Dahlstrom, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Summary: This study investigated DNA methylation in 1304 individuals with type 1 diabetes and identified differentially methylated CpG sites associated with diabetic kidney disease. The methylation at 21 of these sites was found to predict the development of kidney failure.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Mei-Jiao Suo, Wei-Cheng Chen, Zi-Qing Xu, Gui-Xiang Tian, Ting Li, Ping Li, Wei Sheng, Guo-Ying Huang, Xiao-Jing Ma
Summary: The findings suggest that variants in the BCOR gene may predispose individuals in the Chinese Han population to congenital heart disease (CHD).
JOURNAL OF GENE MEDICINE
(2023)
Article
Immunology
Xin Tian, Baoyi Liu, Lijie Chen, Yongyi Xie, Jingyao Liang, Yan Yang, Lei Shao, Jing Zhang, Jianqin Wang, Xibao Zhang, Zhouwei Wu, Yumei Liu
Summary: This study identified marked Th17 activation in Chinese patients with atopic dermatitis (AD), as well as alterations in the expression of IL17A, IL4R, AQP5, and CFTR in AD patients with allergic rhinitis (AR) that were associated with AR severity. These findings partially explained the phenotypic differences among AD subtypes and provided potential references for endotype-targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Yu-Jer Hsiao, Hao-Kai Chuang, Sheng-Chu Chi, Yung-Yu Wang, Pin-Hsuan Chiang, Pai-Chi Teng, Tung-Mei Kuang, Aliaksandr A. Yarmishyn, Tai-Chi Lin, De-Kuang Hwang, Shih-Jen Chen, Shih-Hwa Chiou, Mei-Ju Chen, Ai-Ru Hsieh, Chih-Chien Hsu
Summary: This study conducted a GWAS based on the Taiwan Biobank, identifying 138 independent glaucoma-associated SNPs. A polygenic risk score model was successfully constructed to predict the risk of glaucoma in individuals, and its effectiveness was validated in the Han Chinese population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Plant Sciences
Hui Xia, Ziyuan Hao, Yufang Shen, Zhonghua Tu, Lichun Yang, Yaxian Zong, Huogen Li
Summary: In this study, GWAS analysis identified multiple significant loci associated with growth trajectories in hybrid Liriodendron populations. These loci showed temporal variations in effect sizes and inheritance patterns potentially related to different growth and development stages. The identified loci can be beneficial for selecting superior genotypes and provide a foundation for future molecular-assisted breeding.
Article
Biochemistry & Molecular Biology
Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, Huaying Fang, Fei Chen, Yingchang Lu, Noah L. Tsao, Sridharan Raghavan, Satoshi Koyama, Bryan R. Gorman, Marijana Vujkovic, Derek Klarin, Michael G. Levin, Nasa Sinnott-Armstrong, Genevieve L. Wojcik, Mary E. Plomondon, Thomas M. Maddox, Stephen W. Waldo, Alexander G. Bick, Saiju Pyarajan, Jie Huang, Rebecca Song, Yuk-Lam Ho, Steven Buyske, Charles Kooperberg, Jeffrey Haessler, Ruth J. F. Loos, Ron Do, Marie Verbanck, Kumardeep Chaudhary, Kari E. North, Christy L. Avery, Mariaelisa Graff, Christopher A. Haiman, Loic Le Marchand, Lynne R. Wilkens, Joshua C. Bis, Hampton Leonard, Botong Shen, Leslie A. Lange, Ayush Giri, Ozan Dikilitas, Iftikhar J. Kullo, Ian B. Stanaway, Gail P. Jarvik, Adam S. Gordon, Scott Hebbring, Bahram Namjou, Kenneth M. Kaufman, Kaoru Ito, Kazuyoshi Ishigaki, Yoichiro Kamatani, Shefali S. Verma, Marylyn D. Ritchie, Rachel L. Kember, Aris Baras, Luca A. Lotta, Sekar Kathiresan, Elizabeth R. Hauser, Donald R. Miller, Jennifer S. Lee, Danish Saleheen, Peter D. Reaven, Kelly Cho, J. Michael Gaziano, Pradeep Natarajan, Jennifer E. Huffman, Benjamin F. Voight, Daniel J. Rader, Kyong-Mi Chang, Julie A. Lynch, Scott M. Damrauer, Peter W. F. Wilson, Hua Tang, Yan Sun, Philip S. Tsao, Christopher J. O'Donnell, Themistocles L. Assimes
Summary: This study incorporates a diverse cohort of individuals to explore the genetic landscape of coronary artery disease. The researchers discovered novel loci associated with the disease in different ancestral groups, and identified common haplotypes that contribute to risk stratification. They also found genetic overlaps between coronary artery disease and clinical coronary atherosclerosis, and related these genetic factors to insulin resistance and other traits.
Article
Environmental Sciences
Yu Qin, Meixuan Li, Jiani Han, Gecheng Cui, Weiping Du, Kehu Yang
Summary: This study explored the research hotspots and trends of Kinesio Taping in the past decade through bibliometric analysis. The results revealed that pain relief, sports injury prevention and treatment, and proprioception enhancement for improved postural control were important research areas in the field of Kinesio Taping.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Junjie Cao, Renzhi Pei, Ying Lu, Zhongzheng Zheng, Zhiyang Yuan, Daiyang Li, Pisheng Zhang, Xuhui Liu, Dong Chen, Xiaohong Du, Lieguang Chen, Shuangyue Li, Peipei Ye, Tiantian Wang
Summary: The study found that the modified antithymocyte globulin-post-transplant cyclophosphamide combination can decrease the risk of acute and chronic graft-versus-host disease and improve graft-versus-host disease and relapse-free survival in high-risk acute myeloid leukemia and myelodysplastic syndrome patients after allogeneic hematopoietic stem cell transplantation.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wenlin Lu, Xuhui Liu, Linghui Zhao, Shirong Yan, Qingyun Song, Cao Zou, Xun Li
Summary: This study investigated the role and mechanism of miR-22-3p in heart failure, and found that its overexpression inhibits cell activity and promotes cell apoptosis. MiR-22-3p increases the risk of heart failure damage by negatively regulating FURIN.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Xu Chi, Qian Chen, Zhi-An Lan, Xirui Zhang, Xiong Chen, Xinchen Wang
Summary: Conjugated polymers (CPs) have received increasing attention in photocatalysis due to their stability and molecular tunability. In this study, a new efficient cyano (CN) engineering approach was proposed to enhance the photocatalytic performance of CPs. Three CP-based photocatalysts with different CN contents were synthesized to investigate the relationship between CN functionalization and photocatalytic activity. Experimental and theoretical studies revealed that CN functionalization strengthened the donor-acceptor (D-A) interaction, enhanced light absorption, charge separation/transfer efficiency, hydrophilicity of CPs, and facilitated the output of photoinduced electrons from CPs to Pt cocatalyst.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Plant Sciences
Hongling Zhang, Guiqiong Li, Min Jiang, Changling Zhao, Pengyu Zhao, Chen Wang, Guosong Wen, Feng Zhou, Wenhua Dongchen, Shaozhong Xu, Ting Mu, Fanlai Meng, Xinglei Xiao, Di Yang, Zhengjie Liu, Ya Zhou, Qin Xiong
Summary: The expression of flavonoid synthesis-related genes in Panax notoginseng stems shows multi-peak curves, and the distribution of total flavonoid and anthocyanin content in the stems is asymmetric, mainly concentrated in the upper parts. The correlations between gene expression and flavonoid accumulation are highly diverse.
ACTA PHYSIOLOGIAE PLANTARUM
(2023)
Review
Endocrinology & Metabolism
Liangying Hou, Qi Wang, Bei Pan, Rui Li, Yanfei Li, Juanjuan He, Tianzhu Qin, Liujiao Cao, Na Zhang, Changhao Cao, Long Ge, Kehu Yang
Summary: The study aimed to determine the effects of different exercise modalities in patients with type 2 diabetes mellitus. Results showed that various exercise modalities can improve glycemic control in diabetes patients, with supervised exercises being the most effective. Flexibility and balance exercises also have benefits, but the impact on TG levels remains unclear.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Physics, Multidisciplinary
Xingxing Yang, Yang Li, Xin Guo, Meiling Ding, Jingxuan Yang
Summary: This paper proposes a strategy to reduce energy consumption by storing and transmitting regenerative energy of trains through multi-agent simulation. By optimizing the train operation time and dwell time, the traction energy consumption is reduced, and the accuracy of the simulation model is validated in a practical case study.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Review
Obstetrics & Gynecology
Liu Yang, Lufang Feng, Lijuan Huang, Xuejiao Li, Wenwen Qiu, Kehu Yang, Jie Qiu, Haihong Li
Summary: This study conducted a meta-analysis to identify the association between maternal factors and intrauterine growth retardation (IUGR), and found that smoking, primiparity, prepregnancy BMI < 18.5, poor gestational weight gain, pregnancy-induced hypertension, anemia, and hypoproteinemia were associated with IUGR. These findings could contribute to the development of risk prediction models and improve management and education for child-bearing or early pregnant women.
REPRODUCTIVE SCIENCES
(2023)
Article
Biology
Shu Zhang, Chang Wang, Yue Wang, Hao Zhang, Chen Xu, Yiwei Cheng, Yan Yuan, Jiahao Sha, Xuejiang Guo, Yiqiang Cui
Summary: In this study, an endogenous circular RNA (circRsrc1) was discovered, which encodes a novel protein (Rsrc1-161aa). Deletion of Rsrc1-161aa in mice resulted in impaired male fertility, characterized by decreased sperm count and motility due to mitochondrial energy metabolism dysfunctions. In vitro experiments showed that circRsrc1 regulates mitochondrial functions through its encoded protein Rsrc1-161aa. Mechanistically, Rsrc1-161aa interacts with mitochondrial protein C1qbp to enhance its binding activity to mitochondrial mRNAs, thereby regulating mitochondrial ribosome assembly and translation.
Article
Biochemistry & Molecular Biology
Li Liu, Haojie Li, Mengjie Wang, Xiangzheng Zhang, Jie Ren, Yan Yuan, Jiahao Sha, Xuejiang Guo
Summary: Epigenetic regulation, specifically histone post-translational modifications (PTMs), is involved in the differentiation of spermatogonial stem cells (SSCs). However, due to the low number of SSCs in vivo, there is a lack of systematic studies on the regulation of histone PTMs during SSCs differentiation. In this study, we used targeted quantitative proteomics with mass spectrometry and RNA-seq data to quantify the dynamic changes of 46 different PTMs on histone H3.1 during SSCs differentiation in vitro. We identified seven differentially regulated histone H3.1 modifications and further identified specific binding proteins for H3K9me2 and H3S10ph, including transcription factors GTF2E2 and SUPT5H, which appear to play a crucial role in the epigenetic regulation of SSC differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Bing Wang, Xiangzheng Zhang, Chen Xu, Xudong Han, Yue Wang, Chenghao Situ, Yan Li, Xuejiang Guo
Summary: The study introduces a new deep learning framework, DeepSP, for protein subcellular localization (PSL) prediction using mass spectrometry-based spatial proteomics data. By capturing detailed changes in protein occupancy profiles across subcellular fractions, DeepSP constructs a new feature map and utilizes a convolutional block attention module to enhance PSL prediction performance. DeepSP demonstrates significant improvement in accuracy and robustness compared to current machine learning predictors, making it a valuable tool for spatial proteomics studies and the understanding of protein function.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Chemistry, Physical
Ye Ji, Xi-Lian Guo, Jia-Yu Yang, Hai-Han Zhang, Xu-Hui Liu, Ming-Xing Song, Zheng-Kun Qin, Jia Wang, Fu-Quan Bai
Summary: In this article, six novel heterocyclic Ir(III) complexes were designed and calculated using DFT and TD-DFT. The bands of the lowest-lying absorptions and lowest energy emissions, as well as the spectral properties, frontier molecular orbitals, and spin-orbital coupling values, were studied. These complexes exhibit low efficiency roll-off properties, which is significant for the development of OLEDs.
Article
Biochemistry & Molecular Biology
Guoshun Liu, Xuhui Liu, Xingdong Ma, Xiaoqi Tang, Xiaobin Zhang, Jianxia Dong, Yunfei Ma, Xiaobei Zang, Ning Cao, Qingguo Shao
Summary: Dual-ion batteries (DIBs) are a new type of energy storage device that store both anions and cations. Combining graphite cathodes with high-capacity silicon anodes can improve the energy density of DIBs.
Article
Materials Science, Multidisciplinary
Lingjie Meng, Xuhui Liu, Qingxiang Hong, Yan Ji, Lingtao Wang, Qiuyang Zhang, Jie Chen, Changjiang Pan
Summary: In this study, a Zn2+-loaded polydopamine (PDA/Zn2+) coating was prepared on an alkali-heat-treated magnesium alloy surface inspired by mussel adhesion protein. The coating showed excellent wettability and selective promotion of albumin adsorption. Furthermore, the corrosion resistance, hemocompatibility, and endothelialization of the modified magnesium alloys were significantly improved with the increase of Zn2+ content in the coating.
Article
Oncology
Peng Xie, Siqing Wu, Zichong Kuo, Huidong Tian, Qiangsheng He, Yanfei Li, Ningning Mi, Linmin Hu, Haitong Zhao, Wenjing Li, Bin Xia, Jinqiu Yuan, Kehu Yang, Changhua Zhang, Yulong He
Summary: This study aimed to investigate the individual and joint effects of modifiable healthy lifestyle and metabolic health status on colorectal cancer incidence and mortality. The results showed that adherence to a healthy lifestyle could substantially reduce the burden of colorectal cancer, and behavioral lifestyle changes should be encouraged for colorectal cancer prevention even in participants with metabolic syndrome.
FRONTIERS IN ONCOLOGY
(2023)
