Efficient discovery of bioactive scaffolds by activity-directed synthesis

Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

(2013) T. Hirose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In situ click chemistry: probing the binding landscapes of biological molecules

(2010) Sreeman K. Mamidyala et al.   CHEMICAL SOCIETY REVIEWS

Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery

(2010) Lorna H. Mitchell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling Factors for C−H Functionalization versus Cyclopropanation of Dihydronaphthalenes

(2010) Etienne Nadeau et al.   JOURNAL OF ORGANIC CHEMISTRY

Bioactivity-guided mapping and navigation of chemical space

(2009) Steffen Renner et al.   Nature Chemical Biology

Interactive exploration of chemical space with Scaffold Hunter

(2009) Stefan Wetzel et al.   Nature Chemical Biology

Regioselective access to substituted oxindoles via rhodium-catalyzed carbene C–H insertion

(2009) Delphine Gauthier et al.   TETRAHEDRON

Natural Compounds: Leads or Ideas? Bioinspired Molecules for Drug Discovery

(2008) Terence Beghyn et al.   Chemical Biology & Drug Design

Structural Diversity of Organic Chemistry. A Scaffold Analysis of the CAS Registry

(2008) Alan H. Lipkus et al.   JOURNAL OF ORGANIC CHEMISTRY