Article
Chemistry, Multidisciplinary
Xianglian Li, Hui Liu, Ailing Yu, Dan Lin, Zhishu Bao, Yuqin Wang, Xingyi Li
Summary: The newly designed NapFFKKFKLKL/Dexp supramolecular hydrogel displayed controlled drug release behavior, good intraocular biocompatibility, and potent anti-inflammatory capacity, making it a promising drug carrier system for treating posterior disorders such as uveitis.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xin Qi, Yundi Zhao, Kacper Lachowski, Julia Boese, Yifeng Cai, Orion Dollar, Brittney Hellner, Lilo Pozzo, Jim Pfaendtner, Jaehun Chun, Francois Baneyx, Christopher J. Mundy
Summary: This study develops a theoretical framework that combines interactions at the molecular and macroscopic scales based on colloidal theory and atomistic molecular dynamics simulations. It accurately captures the macroscopic behavior of complex bioinspired material systems.
Review
Chemistry, Multidisciplinary
Amrita Sikder, Saptarshi Chakraborty, Priya Rajdev, Pradip Dey, Suhrit Ghosh
Summary: Bioinspired self-assembly using amphiphiles with hydrophobic supramolecular-structure-directing-units has led to the creation of highly stable nanostructures, which are fundamentally different from traditional amphiphiles. The supramolecular assembly is primarily controlled by the specific molecular-recognition motif of the SSDU, enabling precise regulation of internal order and morphology. Additionally, SSDU-derived pi-amphiphiles have shown promise in producing temperature and redox-responsive supramolecular polymers with efficient functional group display and biological activity.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Yong Sun, Xing Li, Mingda Zhao, Yafang Chen, Yang Xu, Kefeng Wang, Shaoquan Bian, Qing Jiang, Yujiang Fan, Xingdong Zhang
Summary: A new class of biphenyl-tripeptides capable of self-assembling into robust supramolecular nanofiber hydrogels was developed. Molecular dynamics simulations revealed that reasonable hydrogen bond interactions and the presence of FF brick promoted the formation of the hydrogels. Rheology and spectroscopy analysis were used to analyze the biomechanical properties and intermolecular interactions of the hydrogels, and optimize the amino acid sequence. The results demonstrated the good biocompatibility and biological activity of these supramolecular nanofiber hydrogels, making them promising for applications in regenerative medicine.
BIOACTIVE MATERIALS
(2022)
Article
Automation & Control Systems
Ning Zhao, Liang Gao, Zhiyuan Yang, Jian Qi, Kai Han, Xin Sui, Jie Zhao, Yanhe Zhu
Summary: This study proposes a self-assembly strategy inspired by biological cooperative and mutual assistance behaviors, to enable the modular space robot to reorganize into different structures with different functions. The strategy utilizes the meta-module method to give nonmobile modules mobility and utilizes mutual assistance to achieve position and posture reachability of the assembly unit. An assembly planner is designed based on the motion characteristics of the meta-module and mutual assistance to obtain assembly sequences for self-manufacturing desired configurations.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Ikuya Matsumoto, Ryo Sekiya, Takeharu Haino
Summary: By decorating nanographenes with alkyl chains and controlling concentration, solvent polarity, temperature, and sonication, it is possible to achieve self-assembly and formation of stacked structures. Optical measurements and AFM images confirm the presence of stacked structures, while molecular mechanics calculations model the interactions within the aggregates. The nanographenes exhibit concentration-dependent morphologies, forming stacked structures at low concentrations and polymer-like network structures at higher concentrations on mica.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chong-Bin Tian, Qing-Fu Sun
Summary: Discrete organopalladium coordination cages have great potential in various applications such as molecular recognition and sensing, drug delivery, and enzymatic catalysis. Heteroleptic cages with complex architectures and anisotropic cavities have received increasing attention recently. This concept article discusses a powerful self-assembly strategy for constructing a family of organopalladium cages from a given library of ligands, including both homoleptic and heteroleptic structures. The heteroleptic cages often exhibit fine-tuned structures and emergent properties, distinct from their homoleptic counterparts. The concepts and examples provided in this article offer rational guidance for the design of new coordination cages with advanced functions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Xinwei Li, Kian Meng Lim, Wei Zhai
Summary: The advent of advanced manufacturing technologies has the potential to create novel materials with unprecedented material properties. Through a specific manufacturing method, the discontinuous interpenetrating-phase composite (d-IPC) demonstrates unique mechanical properties and high energy absorption capability.
APPLIED MATERIALS TODAY
(2022)
Article
Chemistry, Multidisciplinary
Raghu Pradeep Narayanan, Abhay Prasad, Alex Buchberger, Lei Zou, Julio Bernal-Chanchavac, Tara Macculloch, Nour Eddine Fahmi, Hao Yan, Fei Zhang, Matthew J. Webber, Nicholas Stephanopoulos
Summary: The combination of multiple orthogonal interactions enables hierarchical complexity in self-assembled nanoscale materials. This study demonstrates the efficient supramolecular polymerization of DNA origami nanostructures using a multivalent display of small molecule host-guest interactions, and exploits high-affinity CB[7]-adamantane interactions to enable responsive enzymatic actuation.
Review
Pharmacology & Pharmacy
Matthew J. Webber, E. Thomas Pashuck
Summary: Hydrogels prepared via self-assembly offer scalable and tunable platforms for drug delivery applications. Peptides are widely used as building blocks for self-assembly, while stimuli-responsive self-assembly provides opportunities for more precise drug action. Double-network hydrogels combine the beneficial properties of both self-assembled and covalent networks.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Changxu Ren, Peng Yang, Jiaonan Sun, Eric Y. Bi, Jinyu Gao, Jacob Palmer, Mengqiang Zhu, Yiying Wu, Jinyong Liu
Summary: This study introduces a hybrid catalyst for reducing aqueous ClO4- into Cl- at room temperature with 1 atm of H-2, showing high turnover number and turnover frequency.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Sylvain Sudan, Farzaneh Fadaei-Tirani, Rosario Scopelliti, Kristina E. Ebbert, Guido H. Clever, Kay Severin
Summary: Thirteen palladium-ligand assemblies with different structures and topologies were studied for their ability to bind lithium ions. It was found that the addition of LiBF4 caused a significant structural rearrangement in one case, converting a dinuclear [Pd2L4](4+) complex into a low-symmetry [Pd4L8](8+) assembly with two binding pockets for solvated LiBF4 ion pairs. This rearrangement was only induced by Li+, indicating highly specific host-guest interactions. Structural analysis revealed that the [Pd4L8](8+) receptor had a compact structure with multiple intramolecular interactions, similar to natural and synthetic foldamers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Peidong Du, Shichao Xu, Zhi-Kang Xu, Zhen-Gang Wang
Summary: Designing a favorable microenvironment around enzymes is crucial for tuning their functions and reshaping biocatalytic activities, with supramolecular self-assembly being an effective approach. This review focuses on the progress, relationship between physicochemical properties, and the dynamic regulation of catalytic systems through self-assembly. Insights are provided on overcoming obstacles and future directions in enzyme microenvironment engineering.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Yutong Wang, Lijun Yang, Mengfan Wang, Jiaxing Zhang, Wei Qi, Rongxin Su, Zhimin He
Summary: Enzymes play crucial roles in biochemical reactions due to their highly organized structure and catalytic groups. By self-assembling de novo designed helical heptapeptides, a phosphatase-like mimic was created with significant catalytic activity, highlighting the importance of helical structure in enzymatic catalysis.
Article
Chemistry, Multidisciplinary
Liling Chen, Run Meng, Rui Qing, Wenfeng Li, Ziwei Wang, Yao Hou, Jia Deng, Wei Pu, Zibin Gao, Bochu Wang, Shilei Hao
Summary: We have successfully developed robust keratin hydrogels based on mechanism study through recombinant proteins, which outperform combinations of native proteins in mechanical properties and in biomedical applications.
Article
Biochemistry & Molecular Biology
Abu-Hussien, Guru Krishnakumar Viswanathan, Luba Simhaev, Ashim Paul, Hamutal Engel, Ehud Gazit, Daniel Segal
Summary: The specific residues of the human gamma D-crystallin protein were found to play an important role in the amyloidogenicity of GDC6, facilitating peptide-peptide interactions. By validating the amyloidogenic propensity of peptide variants, it was revealed that these specific residues are crucial for the amyloidogenicity of GDC6.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Om Shanker Tiwari, Krishna N. Ganesh, Ehud Gaze
Summary: The effect of stereochemistry and hydrophobicity on self-assembly of Phe-Phe dipeptide nucleoside conjugates has been studied. It was found that homochiral dipeptides form nanorod structures while heterochiral dipeptides do not form regular structures. The self-assembly of chiral nucleoside-conjugated Phe-Phe peptides results in spherical particles.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zhang, Qi Li, Haoran Wu, Yancheng Wang, Yan Wang, Sigal Rencus-Lazar, Yurong Zhao, Jiqian Wang, Deqing Mei, Hai Xu, Ehud Gazit, Kai Tao
Summary: Amino acids are bio-building blocks that play various roles in metabolic activities. Supramolecular structures formed by amino acids exhibit amyloid-like characteristics, which are driven by hydrogen bonds and play critical roles in the properties and applications of amino acid assemblies. Tyrosine-based superstructures have diverse properties and functions, making them promising next-generation biomaterials for biomedical applications. However, modulating the energetically stable supramolecular structures of tyrosine-based organizations is challenging. By assembling L-Y and D-Y, the secondary structures of the supramolecular assemblies can be modulated, leading to distinct organization kinetics and modulation of physicochemical properties.
Review
Chemistry, Multidisciplinary
Nikhil Bajpayee, Thangavel Vijayakanth, Sigal Rencus-Lazar, Sneha Dasgupta, Aamod V. Desai, Rahul Jain, Ehud Gazit, Rajkumar Misra
Summary: Flexible and biocompatible metal peptide frameworks (MPFs) have been developed from short and ultra-short peptides for various applications such as greenhouse gas storage, molecular recognition, and chiral transformations. Recently, specifically folded peptides have been utilized to fabricate metal helix frameworks (MHFs) that control the formation of three-dimensional (3D)-MHFs. This article describes the recent progress of metal-driven folded peptide assembly for constructing 3D porous structures with potential applications in energy storage, chiral recognition, and biomedical fields, serving as an alternative to conventional metal-organic frameworks (MOFs).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Geriatrics & Gerontology
Rony M. Sayig-Keren, Moria Dagan, Pablo Cornejo Thumm, Marina Brozgol, Eran Gazit, Brad Manor, Jeffrey M. Hausdorff
Summary: This study examines the effects of theta-tACS on dual-task walking and cognitive function in older adults. The results show that theta-tACS and tDCS have similar effects in reducing dual-task costs, suggesting that theta-tACS may influence the fronto-parietal network and improve dual-tasking.
Article
Chemistry, Physical
Jiahao Zhang, Yan Zhang, Yancheng Wang, Sigal Rencus-Lazar, Deqing Mei, Ehud Gazit, Kai Tao
Summary: Bio-organic adaptive photonic crystals (PCs) are fabricated by drop-casting amphiphilic guanine-based peptide nucleic acid self-assembled microspheres. The configurations and structural coloration of the supramolecular PCs are sensitive to self-assembly influencing parameters, showing temperature-encoded structural color evolution and solvent polarity-dependent solvatochromism. These findings suggest that supramolecular PCs have promising potential for environmental protection and optical applications.
Review
Chemistry, Multidisciplinary
Vijay Bhooshan Kumar, Ifat Sher, Sigal Rencus-Lazar, Ygal Rotenstreich, Ehud Gazit
Summary: Carbon quantum dots (CDs) are emerging carbonaceous nanomaterials with excellent fluorescent properties, small size, cell and tissue penetration ability, ease of synthesis, surface modification, low cytotoxicity, and superior water dispersion. They have great potential as bioimaging probes, drug carriers, and disease diagnostics. Functionalized CDs show promise in the diagnosis and treatment of ocular diseases, including macular and anterior segment diseases, as well as targeting A beta amyloids in the retina.
Article
Multidisciplinary Sciences
Luca Palmerini, Luca Reggi, Tecla Bonci, Silvia Del Din, M. Encarna Mico-Amigo, Francesca Salis, Stefano Bertuletti, Marco Caruso, Andrea Cereatti, Eran Gazit, Anisoara Paraschiv-Ionescu, Abolfazl Soltani, Felix Kluge, Arne Kuederle, Martin Ullrich, Cameron Kirk, Hugo Hiden, Ilaria D'Ascanio, Clint Hansen, Lynn Rochester, Claudia Mazza, Lorenzo Chiari
Summary: This study provides an example of organizing, integrating, and storing movement data recorded from different wearables and gold standard technologies. The guidelines derived from the experience of a large multi-centric study offer support for accessing, understanding, and reusing available data, promoting standardization and integration in other studies, and facilitating comparison of recorded data in the scientific community.
Review
Pharmacology & Pharmacy
Vijay Bhooshan Kumar, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, Ehud Gazit
Summary: Tissue engineering is focused on restoring or replacing damaged tissues, and peptide self-assembly, particularly RGD peptides, is an effective method for developing tissue structures and functionalities. This review summarizes the progress of RGD application in tissue and organ development, examines its impact on TE efficacy in clinical and preclinical studies, and outlines recent advancements in the use of RGD functionalized biomaterials for tissue regeneration.
Article
Chemistry, Multidisciplinary
Ruth Aizen, Zohar A. Arnon, Or Berger, Antonella Ruggiero, Dor Zaguri, Noam Brown, Evgeny Shirshin, Inna Slutsky, Ehud Gazit
Summary: Nucleobase crystals have unique fluorescence properties in the visible spectrum, unlike their monomeric counterparts. Additionally, some nucleobases exhibit a red edge excitation shift, which is uncommon in the field of organic supramolecular materials and may have implications in therapeutic and materials science.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Om Shanker Tiwari, Ruth Aizen, Massimiliano Meli, Giorgio Colombo, Linda J. W. Shimon, Noam Tal, Ehud Gazit
Summary: Molecular self- and co-assembly have the ability to form diverse and well-defined supramolecular structures with notable physical properties. By exploring the co-assembly of L-His with different aromatic amino acids, including Phe, Tyr, and Trp, we expanded the structural space of amino acid nanomaterials. The best seamless co-assembly was observed between L-His and L-Phe, resulting in the formation of single crystals.
Article
Chemistry, Physical
Yunxiao Wang, Qiang Geng, Yan Zhang, Lihi Adler-Abramovich, Xinyuan Fan, Deqing Mei, Ehud Gazit, Kai Tao
Summary: In this article, the mechanisms underlying the self-assembly of 9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), the preparation methodologies of Fmoc-FF hydrogels, and the properties and applications of Fmoc-FF self-assemblies are systematically summarized. The contemporary shortcomings that limit the development of Fmoc-FF self-assembly are raised, and alternative solutions and future research perspectives are proposed.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou, Yu Chen, Ehud Gazit, Phanourios Tamamis
Summary: The design of novel cancer drug nanocarriers is crucial in cancer therapeutics. Nanomaterials, especially self-assembling peptides, show great potential in drug delivery by promoting drug release and stability while reducing side effects. This review highlights the importance of metal coordination, structure stabilization, cyclization, and minimalism in the design of peptide self-assembled nanocarriers for cancer drug delivery. Future perspectives suggest that incorporating these materials into single or multicomponent systems could lead to novel classes of cancer drug delivery systems.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Computer Science, Interdisciplinary Applications
Gaelle Prigent, Kamiar Aminian, Andrea Cereatti, Francesca Salis, Tecla Bonci, Kirsty Scott, Claudia Mazza, Lisa Alcock, Silvia Del Din, Eran Gazit, Clint Hansen, Anisoara Paraschiv-Ionescu
Summary: This study aims to validate a robust walking detection algorithm using a single foot-worn inertial measurement unit (IMU) in real-life settings. Accurate walking detection was obtained, with sensitivity and specificity of 98% and 91% respectively. A validated algorithm would pave the way for assessing patient performance and gait quality in real-world conditions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Biotechnology & Applied Microbiology
Francesca Salis, Stefano Bertuletti, Tecla Bonci, Marco Caruso, Kirsty Scott, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Clemens Becker, Philip Brown, Anne-Elie Carsin, Brian Caulfield, Lorenzo Chiari, Ilaria D'Ascanio, Silvia Del Din, Bjoern M. Eskofier, Judith Garcia-Aymerich, Jeffrey M. Hausdorff, Emily C. Hume, Cameron Kirk, Felix Kluge, Sarah Koch, Arne Kuederle, Walter Maetzler, Encarna M. Mico-Amigo, Arne Mueller, Isabel Neatrour, Anisoara Paraschiv-Ionescu, Luca Palmerini, Alison J. Yarnall, Lynn Rochester, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Ugo Della Croce, Claudia Mazza, Andrea Cereatti
Summary: This study presents a wearable multi-sensor system (INDIP) that accurately assesses people's gait in real-world conditions. The system performed well in different cohorts and gait patterns, and was easy to use. Therefore, it can be considered a valid and feasible solution for analyzing gait in real-world conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
