A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr

The Order Bacillales Hosts Functional Homologs of the WorrisomecfrAntibiotic Resistance Gene

(2012) Lykke H. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transferable Plasmid-Mediated Resistance to Linezolid Due tocfrin a Human Clinical Isolate of Enterococcus faecalis

(2012) Lorena Diaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Covalent Intermediate in the Catalytic Mechanism of the Radical S-Adenosyl-l-methionine Methyl Synthase RlmN Trapped by Mutagenesis

(2012) Kevin P. McCusker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

LEADER Program Results for 2009: an Activity and Spectrum Analysis of Linezolid Using 6,414 Clinical Isolates from 56 Medical Centers in the United States

(2011) David J. Farrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cfr and RlmN Contain a Single [4Fe-4S] Cluster, which Directs Two Distinct Reactivities forS-Adenosylmethionine: Methyl Transfer by SN2 Displacement and Radical Generation

(2011) Tyler L. Grove et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical S-adenosylmethionine enzymes: Mechanism, control and function

(2011) Martin R. Challand et al.   NATURAL PRODUCT REPORTS

RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

(2011) F. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Radically Different Mechanism for S-Adenosylmethionine-Dependent Methyltransferases

(2011) T. L. Grove et al.   SCIENCE

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

From the Structure and Function of the Ribosome to New Antibiotics (Nobel Lecture)

(2010) Thomas A. Steitz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and Characterization of the Multidrug Resistance Gene cfr in a Panton-Valentine Leukocidin-Positive Sequence Type 8 Methicillin-Resistant Staphylococcus aureus IVa (USA300) Isolate

(2010) A. C. Shore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus

(2010) Gracia Morales et al.   CLINICAL INFECTIOUS DISEASES

Multicity Outbreak of Linezolid‐ResistantStaphylococcus epidermidisAssociated with Clonal Spread of acfr‐Containing Strain

(2010) Hector Bonilla et al.   CLINICAL INFECTIOUS DISEASES

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

(2010) Nora Vázquez-Laslop et al.   EMBO JOURNAL

Clinical Outbreak of Linezolid-Resistant Staphylococcus aureus in an Intensive Care Unit

(2010) Miguel Sánchez García   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy

(2010) R. E. Mendes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

First Report of Staphylococcal Clinical Isolates in Mexico with Linezolid Resistance Caused by cfr: Evidence of In Vivo cfr Mobilization

(2010) R. E. Mendes et al.   JOURNAL OF CLINICAL MICROBIOLOGY

RlmN and Cfr are Radical SAM Enzymes Involved in Methylation of Ribosomal RNA

(2010) Feng Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anaerobic functionalization of unactivated C–H bonds

(2009) Squire J Booker   CURRENT OPINION IN CHEMICAL BIOLOGY

Linezolid surveillance program results for 2008 (LEADER Program for 2008)

(2009) David J. Farrell et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) Katarzyna H. Kaminska et al.   NUCLEIC ACIDS RESEARCH

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States

(2008) R. E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY