Enzyme redesign guided by cancer-derived IDH1 mutations

Progress in understanding 2-hydroxyglutaric acidurias

(2012) Martijn Kranendijk et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Substrate Specificity of 2-Hydroxyglutaryl-CoA Dehydratase fromClostridium symbiosum: Toward a Bio-Based Production of Adipic Acid

(2011) Anutthaman Parthasarathy et al.   BIOCHEMISTRY

A Tale of Two Subunits: How the Neomorphic R132H IDH1 Mutation Enhances Production of αHG

(2011) Beth Pietrak et al.   BIOCHEMISTRY

Theoretical Insights into Heme-Catalyzed Oxidation of Cyclohexane to Adipic Acid

(2011) Holger Noack et al.   INORGANIC CHEMISTRY

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP+-Dependent Isocitrate Dehydrogenase Mutations

(2011) Genglin Jin et al.   PLoS One

Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe

(2011) Stacie L. Bulfer et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

A Lysine-Tyrosine Pair Carries Out Acid−Base Chemistry in the Metal Ion-Dependent Pyridine Dinucleotide-Linked β-Hydroxyacid Oxidative Decarboxylases†

(2009) Deniz F. Aktas et al.   BIOCHEMISTRY

Site-Directed Mutagenesis as a Probe of the Acid−Base Catalytic Mechanism of Homoisocitrate Dehydrogenase fromSaccharomyces cerevisiae

(2009) Ying Lin et al.   BIOCHEMISTRY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemical Mechanism of Homoisocitrate Dehydrogenase fromSaccharomyces cerevisiae†

(2008) Ying Lin et al.   BIOCHEMISTRY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE