期刊
NATURE CHEMICAL BIOLOGY
卷 6, 期 5, 页码 324-326出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.348
关键词
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资金
- Volkswagen Foundation [I81/597, I81/797]
- Helmholtz-Initiative on Systems Biology
Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phospholipid residing on early endosomes, where it is proposed to be involved in endosomal fusion. We synthesized membrane-permeant derivatives of PtdIns(3)P, including a caged version that is to our knowledge the first photoactivatable phosphoinositide derivative developed so far. In living cells, photoactivation of caged PtdIns(3)P induced rapid endosomal fusion in an EEA1-dependent fashion, thus providing in vivo evidence that PtdIns(3)P is a sufficient signal for driving this process.
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