期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 12, 页码 879-881出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.235
关键词
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资金
- Howard Hughes Medical Institute
- US National Institute of General Medical Sciences, National Institutes of Health [R01GM065865]
- US National Science Foundation
We developed a general method to detect cellular small molecule-RNA conjugates that does not rely on the reactivity of the small molecule. This technique revealed NAD-linked RNA in Escherichia coli and Streptomyces venezuelae. Subsequent characterization showed that NAD is a 5' modification of RNA, cannot be installed in vitro through aberrant transcriptional initiation, is only found among smaller cellular RNAs and is present at a surprisingly high abundance of similar to 3,000 copies per cell.
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