期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 12, 页码 874-875出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.261
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资金
- NIDDK NIH HHS [R01 DK052380, R01 DK030534] Funding Source: Medline
Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.
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