期刊
NATURE CHEMICAL BIOLOGY
卷 5, 期 2, 页码 76-77出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio0209-76
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Syntheses of natural product-like compound libraries with high scaffold diversity have proven hard to develop. A strategy employing metathesis cascades to 'zip up' a set of unsaturated building blocks differently connected by variable linkers demonstrates that over 80 distinct scaffold classes can be synthesized in one go.
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