Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2

A fluorescent membrane tension probe

(2018) Adai Colom et al.   Nature Chemistry

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

(2017) Manoël Prouteau et al.   NATURE

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

(2017) Andrea L. Marat et al.   SCIENCE

Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

(2017) Manikandan Karuppasamy et al.   Nature Communications

Headgroup engineering in mechanosensitive membrane probes

(2016) Saeideh Soleimanpour et al.   CHEMICAL COMMUNICATIONS

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases

(2016) Tomomi Narita et al.   Scientific Reports

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering

(2015) Xiaodong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

(2015) Delphine Rispal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

Hog1: 20 years of discovery and impact

(2014) J. L. Brewster et al.   Science Signaling

Membrane Tension in Rapidly Moving Cells Is Determined by Cytoskeletal Forces

(2013) Arnon D. Lieber et al.   CURRENT BIOLOGY

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

(2013) Alf Honigmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Eisosomes and plasma membrane organization

(2012) Agustina Olivera-Couto et al.   MOLECULAR GENETICS AND GENOMICS

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

Laurdan generalized polarization fluctuations measures membrane packing micro-heterogeneity in vivo

(2012) S. A. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use the force: membrane tension as an organizer of cell shape and motility

(2012) Alba Diz-Muñoz et al.   TRENDS IN CELL BIOLOGY

Regulation of Cell Wall Biogenesis inSaccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway

(2011) David E. Levin   GENETICS

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

Lateral reorganization of plasma membrane is involved in the yeast resistance to severe dehydration

(2010) Sebastien Dupont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Biology and Physics of Cell Shape Changes in Development

(2009) Ewa Paluch et al.   CURRENT BIOLOGY

Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae

(2009) Stefan Hohmann   FEBS LETTERS

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

(2009) Doris Berchtold et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Positive Regulators of the Yeast Fps1 Glycerol Channel

(2009) Sara E. Beese et al.   PLoS Genetics

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

Plasma membrane microdomains regulate turnover of transport proteins in yeast

(2008) Guido Grossmann et al.   JOURNAL OF CELL BIOLOGY

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY