Article
Biochemistry & Molecular Biology
Maya Emmons-Bell, Iswar K. Hariharan
Summary: The membrane potential of cells is patterned in the Drosophila wing imaginal disc, with anterior cells near the boundary being more depolarized due to Hh signalling. This depolarization promotes membrane localization of Smoothened and enhances Hh signalling, demonstrating a mutual reinforcement between membrane depolarization and Hh-dependent signalling.
Article
Biochemistry & Molecular Biology
Guanzhi Li, Ye Deng, Kaiqun Li, Yuchen Liu, Ling Wang, Zhiyong Wu, Chao Chen, Kairui Zhang, Bin Yu
Summary: The study reveals that Hedgehog (Hh) signalling is activated during trauma-induced tendon ossification and regulates antioxidant pathways affecting ROS generation in TDSCs. Downregulation of Hh signalling inhibits tendon ossification, while upregulation promotes the process. Targeting Hh signalling may be a potential treatment for trauma-induced tendon ossification.
Article
Biology
Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M. Betzler, Daryan Kempe, Mate Biro, Nicholas Ariotti, Gregory M. Redpath, Jeremie Rossy
Summary: This study investigates the recruitment of SNX9 to CD28 clusters upon CD28 triggering, which promotes membrane tubulation and regulates the stability of CD28 as well as signaling events. CD28 clusters are shown to be dynamic structures, and SNX9-mediated tubulation generates a membrane environment that facilitates CD28 triggering and downstream signaling events.
Article
Biochemistry & Molecular Biology
Kezhou Wang, Jie Xiong, Yiwen Lu, Lifeng Wang, Tian Tian
Summary: Macrophages are crucial immune cells in tumour immunity, and the subtypes of macrophages, M1 and M2, play different roles in response to different microenvironments. The transcription factor KLF4 and its SUMOylation have been shown to regulate macrophage polarization. SENP1, a specific protease for KLF4 de-SUMOylation, is found to affect M1 macrophage polarization and the activity of tumour cells. This suggests that the SENP1-KLF4 axis could be a potential target in cancer therapy.
Article
Developmental Biology
Adam W. Olson, Vien Le, Jinhui Wang, Alex Hiroto, Won Kyung Kim, Dong-Hoon Lee, Joseph Aldahl, Xiwei Wu, Minhyung Kim, Gerald R. Cunha, Sungyong You, Zijie Sun
Summary: The study demonstrates that stromal androgen receptor (AR) action is crucial for prostate development, and selective deletion of stromal AR expression in prepubescent Gli1-expressing cells disrupts androgen signaling-initiated stromal-epithelial paracrine interactions, leading to growth retardation and developmental defects in pubertal prostate epithelia. Aberrant shh-signaling activation and altered differentiation fates of prostatic epithelial cells are identified as key mechanisms affected by stromal AR deletion.
Article
Biochemistry & Molecular Biology
Yi-Qun Gao, Ling-Hua Bu, Mei-Ling Han, Ya-Ling Wang, Zong-Yun Li, Hong-Tao Liu, Dai-Yin Chao
Summary: Recent studies have shown that blue light regulates primary root growth inhibition under phosphate-deficient conditions through the cryptochromes and their downstream signaling factors. The inhibition of root elongation by low phosphate requires blue light signal perception at the shoot and transduction to the root, where SPA1 and COP1 play a negative role while HY5 plays a positive role. Further experiments revealed that HY5 can migrate from the shoot to root and activate the expression of LPR1 to regulate primary root growth.
Article
Medicine, Research & Experimental
Lamis M. F. El-Baz, Samah M. Elaidy, Hani S. Hafez, Nahla M. Shoukry
Summary: The study demonstrates the crucial role of Shh signaling in the pathogenesis of asthma, suggesting that modulation of Shh signaling may have significant implications for asthma therapy.
Article
Biology
Shu Yang, Xuefeng Wu, Euphrosyne Daoutidou, Ya Zhang, MaryJane Shimell, Kun-Han Chuang, Aidan J. Peterson, Michael B. O'Connor, Xiaoyan Zheng
Summary: This study reveals a novel mechanism by which the Hedgehog (Hh) protein modulates the activity of Bone Morphogenetic Proteins (BMPs) in the developing Drosophila wing. The findings suggest that Hh-induced expression of the Nord protein fine-tunes the range and strength of BMP signaling by regulating their release and activity. Nord acts as a dosage-dependent BMP modulator, promoting signaling at low levels and inhibiting it at high levels.
Article
Cell Biology
Qi Wang, Shiqi Wu, Yanan Gu, Hua Liang, Fei He, Xinyang Wang, Dalin He, Kaijie Wu
Summary: Prostate cancer growth and progression are dependent on androgens, but treatment failure and poor prognosis occur when the cancer becomes androgen independent. In this study, RASAL2 was found to play an oncogenic role in prostate cancer by promoting tumor cell proliferation and growth through the PI3K/AKT/cyclin D1 pathway. RASAL2 expression was higher in cancer tissues and correlated with poorer prognosis. These findings suggest that RASAL2 may be a potential therapeutic target for prostate cancer.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Yu-Ching Wen, Chien-Liang Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Van Thi Ngoc Tram, Michael Hsiao, Jiaoti Huang, Wei-Yu Chen, Yen-Nien Liu
Summary: Our study reveals that LIF/ZBTB46 signaling activation upregulates PCK1-driven glucose metabolism and neuroendocrine differentiation in CRPC. Targeting PCK1 may reduce the neuroendocrine phenotype and inhibit the growth of prostate cancer cells in vitro and in vivo, offering potential improvements in prostate cancer treatment after ADT using PCK1 inhibitors.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Jianping Li, Ziming Wang, Hecheng Li, Jun Cao, Ning Nan, Xiaoqiang Zhai, Ying Liu, Tie Chong
Summary: This study investigates the effects of resveratrol on the progression of prostate cancer through regulation of the Hedgehog signaling pathway. The results demonstrate that resveratrol inhibits tumor growth and expression of related proteins, while promoting epithelial-mesenchymal transition.
Article
Medicine, Research & Experimental
Dandan Dou, Jinghui Liang, Xiangyu Zhai, Guosheng Li, Hongjuan Wang, Liying Han, Lin Lin, Yifei Ren, Shilian Liu, Chuanyong Liu, Wei Guo, Jingxin Li
Summary: The study demonstrated that OXT protects against experimental colitis by modulating DCs through the Pi3K/AKT pathway. The nervous system participates in immune regulation of colitis by modulating DCs. Using OXT-pretreated DCs opens new therapeutic perspectives for the treatment of UC in humans.
Article
Genetics & Heredity
Wanhao Chi, Wei Liu, Wenqin Fu, Shengqian Xia, Ellie S. Heckscher, Xiaoxi Zhuang
Summary: The study demonstrates a significant genetic contribution to Starvation-Induced Hyperactivity (SIH) as a behavioral trait, with RNA binding proteins (RBPs) playing an important role. Through RNA interference and the TARGET system, the study confirms the role of RBP Syp in regulating SIH in adult neurons. RNA-seq analysis reveals alternatively spliced syp under starvation, emphasizing the significance of post-transcriptional processes in behavioral responses to starvation.
Article
Immunology
Guochun Ou, Mingmei Zhu, Yufang Huang, Wen Luo, Jie Zhao, Wenbo Zhang, Hangbiao Xia, Shuhong Wang, Rong He, Qing Xiao, Yan Deng, Rong Qiu
Summary: This study reveals the upregulation of HSP60 expression in COPD and its involvement in the activation of TLR4-MyD88-NF-kappa B signaling pathway and NLRP3 inflammasome, suggesting its potential role in COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Matt J. Barter, Andrew Butcher, Hui Wang, Dimitra Tsompani, Martin Galler, Ellen L. Rumsby, Kirsty L. Culley, Ian M. Clark, David A. Young
Summary: Elevated pro-inflammatory signalling and catabolic metalloproteinase expression are common features of arthritis. HDAC6 has been found to play a crucial role in mediating pro-inflammatory signalling and metalloproteinase gene expression in chondrocytes, thereby providing possible therapeutic targets for arthritis.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Agnes Lim, Markus R. Wenk, Louis Tong
TRENDS IN MOLECULAR MEDICINE
(2015)
Article
Multidisciplinary Sciences
John J. Lee, Michael E. Rothenberg, E. Scott Seeley, Bryan Zimdahl, Sally Kawano, Wan-Jin Lu, Kunyoo Shin, Tomoyo Sakata-Kato, James K. Chen, Maximilian Diehn, Michael F. Clarke, Philip A. Beachy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Correction
Biochemistry & Molecular Biology
Agnes Lim, Markus R. Wenk, Louis Tong
TRENDS IN MOLECULAR MEDICINE
(2016)
Article
Multidisciplinary Sciences
Chen Zhao, Shang Cai, Kunyoo Shin, Agnes Lim, Tomer Kalisky, Wan-Jin Lu, Michael F. Clarke, Philip A. Beachy
Article
Multidisciplinary Sciences
Elaine Y. C. Hsia, Ya Zhang, Hai Son Tran, Agnes Lim, Ya-Hui Chou, Ganhui Lan, Philip A. Beachy, Xiaoyan Zheng
NATURE COMMUNICATIONS
(2017)
Editorial Material
Oncology
Ja Hyeon Ku, Kunyoo Shin, Minyong Kang
TRANSLATIONAL CANCER RESEARCH
(2017)
Article
Oncology
Kunyoo Shin, Agnes Lim, Chen Zhao, Debashis Sahoo, Ying Pan, Edda Spiekerkoetter, Joseph C. Liao, Philip A. Beachy
Article
Cell Biology
Kunyoo Shin, Agnes Lim, Justin I. Odegaard, Jared D. Honeycutt, Sally Kawano, Michael H. Hsieh, Philip A. Beachy
NATURE CELL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
JungHo Kong, Doyeon Ha, Juhun Lee, Inhae Kim, Minhyuk Park, Sin-Hyeog Im, Kunyoo Shin, Sanguk Kim
Summary: A machine learning framework leveraging network-based analyses has been developed to identify biomarkers that can predict immune checkpoint inhibitor treatment response. The predictions based on this framework were found to be more accurate than conventional biomarkers in three different types of cancer.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Yunhee Kim, Inha Kim, Kunyoo Shin
Summary: Recent advancements in stem cell and developmental biology have led to the generation of in vitro models that mimic early mammalian development, offering significant opportunities for embryogenesis research. In this article, the authors provide an overview of current techniques used to model early mammalian embryogenesis, focusing on models created from stem cells derived from humans and mice. By discussing the historical background and fundamental principles, the authors aim to provide a comprehensive understanding of these in vitro models. The article also explores the potential applications of these models in disease modeling and highlights the challenges and future developments in the field of stem cell research.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
JungHo Kong, Heetak Lee, Donghyo Kim, Seong Kyu Han, Doyeon Ha, Kunyoo Shin, Sanguk Kim
NATURE COMMUNICATIONS
(2020)