期刊
NATURE CELL BIOLOGY
卷 15, 期 8, 页码 885-887出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2817
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Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.
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