Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies

(2010) Fernando Calvo et al.   BIOESSAYS

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

The ERK signaling cascade-Views from different subcellular compartments

(2009) Zhong Yao et al.   BIOFACTORS

Selectivity of Docking Sites in MAPK Kinases

(2009) A. Jane Bardwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Modularity of MAP kinases allows deformation of their signalling pathways

(2009) Areez Mody et al.   NATURE CELL BIOLOGY

Sequence patches on MAPK surfaces define protein-protein interactions

(2009) Gary L Johnson et al.   GENOME BIOLOGY

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Endosomal Targeting of MEK2 Requires RAF, MEK Kinase Activity and Clathrin-Dependent Endocytosis

(2008) Emilia Galperin et al.   TRAFFIC