A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol

Dual Roles for PARP1 during Heat Shock: Transcriptional Activator and Posttranscriptional Inhibitor of Gene Expression

(2015) Sejal Vyas et al.   MOLECULAR CELL

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human tRNA synthetase catalytic nulls with diverse functions

(2014) W.-S. Lo et al.   SCIENCE

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

(2014) Jerome C Nwachukwu et al.   eLife

Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens

(2013) Christina J. Matheny et al.   CHEMISTRY & BIOLOGY

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

ARF induction in response to DNA strand breaks is regulated by PARP1

(2013) Giulia Orlando et al.   NUCLEIC ACIDS RESEARCH

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Uncovering of a Short Internal Peptide Activates a tRNA Synthetase Procytokine

(2012) Peter S. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

tRNA-controlled Nuclear Import of a Human tRNA Synthetase

(2012) Guangsen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

(2012) Mathew Sajish et al.   Nature Chemical Biology

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF- B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage

(2011) Y. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Activator-Induced Spread of Poly(ADP-Ribose) Polymerase Promotes Nucleosome Loss at Hsp70

(2011) Steven J. Petesch et al.   MOLECULAR CELL

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

(2011) V M Renault et al.   ONCOGENE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60

(2010) Jiadong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simian Virus 40 Infection Triggers a Balanced Network That Includes Apoptotic, Survival, and Stress Pathways

(2010) V. Butin-Israeli et al.   JOURNAL OF VIROLOGY

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

(2010) D. C. Hegan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes

(2009) Brian C. Smith et al.   ANALYTICAL BIOCHEMISTRY

Mutational Separation of Aminoacylation and Cytokine Activities of Human Tyrosyl-tRNA Synthetase

(2009) Mili Kapoor et al.   CHEMISTRY & BIOLOGY

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

(2009) Nadine Martin et al.   EMBO JOURNAL

Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure

(2009) Laura Formentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

(2009) S. B. Rajamohan et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3  Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

(2009) S. M. Shin et al.   MOLECULAR PHARMACOLOGY

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE