RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

(2012) Arvin C. Dar et al.   NATURE

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

(2012) Holly B. Kordasiewicz et al.   NEURON

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans : rescue by the DAF-16 and HSF-1 pathways

(2011) Andreia Teixeira-Castro et al.   HUMAN MOLECULAR GENETICS

Regional rescue of spinocerebellar ataxia type 1 phenotypes by14-3-3ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration

(2011) Paymaan Jafar-Nejad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms

(2009) Tjakko J. van Ham et al.   EMBO Molecular Medicine

Phosphorylation of ATXN1 at Ser776 in the cerebellum

(2009) Nathan D. Jorgensen et al.   JOURNAL OF NEUROCHEMISTRY

Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF

(2008) Miriam Shaharabany et al.   FEBS Journal

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translating insights from the cancer genome into clinical practice

(2008) Lynda Chin et al.   NATURE

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

(2008) Janghoo Lim et al.   NATURE

The prion organotypic slice culture assay—POSCA

(2008) Jeppe Falsig et al.   Nature Protocols

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES