☆ 4.8 Editorial Material

Gene tweaking for conservation

NATURE (2013)

期刊

NATURE

卷 501, 期 7468, 页码 485-486

出版社

NATURE PUBLISHING GROUP

DOI: 10.1038/501485a

关键词

-

类别

Multidisciplinary Sciences

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Computer Science, Artificial Intelligence

Tweaking Deep Neural Networks

Jinwook Kim, Heeyong Yoon, Min-Soo Kim

Summary: A synaptic join method is proposed to improve the accuracies of specific classes in neural networks by adding certain additional synapses and training only these synapses if necessary. Experimental results show that this method can effectively enhance the accuracies of specific classes in a controllable way.

IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE (2022)

添加到收藏夹

Review Neurosciences

Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities

Joke Terryn, Catherine M. Verfaillie, Philip Van Damme

Summary: Frontotemporal dementia (FTD) is a neurodegenerative disease that leads to behavioral changes and language difficulties. Mutations in progranulin (GRN) are associated with up to one-third of genetic FTD cases worldwide. Despite primarily being linked to neurodegeneration, the biological functions of GRN are diverse, ranging from wound healing to tumor cell growth.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

添加到收藏夹

Editorial Material Chemistry, Physical

Structural tweaking of 2D quantum magnetism

Hu Miao, Gabor B. Halasz

Summary: A combination of various techniques revealed that picometre-scale lattice distortions can reverse magnetic anisotropy and enhance magnetic frustration in atomically thin ruthenium trichloride, opening a path towards realizing a quantum spin liquid in the two-dimensional limit.

NATURE MATERIALS (2023)

添加到收藏夹

Article Genetics & Heredity

Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium

Alon Israeli, Yogev Burko, Sharona Shleizer-Burko, Iris Daphne Zelnik, Noa Sela, Mohammad R. Hajirezaei, Alisdair R. Fernie, Takayuki Tohge, Naomi Ori, Maya Bar

Summary: Morphogenesis and differentiation are critical for organ development and shape determination. In the case of compound-leaved tomato, a prolonged morphogenesis phase is essential for leaflet initiation, leading to the compound leaf form. Genetic factors such as LA, CLAU, TKN2, CK, and GA play important roles in balancing the morphogenesis-differentiation process, with pathways converging on the regulation of cytokinin and gibberellin levels. Comprehensive transcriptomic analyses provide further insights into the molecular basis of differentiation and morphogenesis in plants.

PLOS GENETICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Tweaking host immune responses for novel therapeutic approaches against Mycobacterium tuberculosis

Arnab Roy, Puja Kumari Agnivesh, Shashikanta Sau, Sunil Kumar, Nitin Pal Kalia

Summary: In tuberculosis (TB), the battle between the human host and Mycobacterium tuberculosis involves intricate interactions with immune cells. The pathogen has developed a complex system to evade immune cells, leading to persistence and limiting clearance by the host. Host-directed therapies, which target immune pathways, are emerging approaches to curb mycobacterial infections by modulating host responses. This review discusses the role of immune cells during M. tuberculosis proliferation, provides an updated understanding of immunopathogenesis, and explores host-modulating options for pathogen clearance.

DRUG DISCOVERY TODAY (2023)

添加到收藏夹

Article Limnology

Life on the edge: Hawaiian model for coral evolution

Debashish Bhattacharya, Timothy G. Stephens, Amanda I. Tinoco, Robert H. Richmond, Phillip A. Cleves

Summary: Climate change and anthropogenic stressors have led to the degradation and loss of coral reefs, driving research in genomics, proteomics, and genetics to identify resilient species and populations for restoration. The relatively isolated and species-poor coral reefs in the Hawaiian Archipelago provide an ideal platform for advancing coral biology and conservation efforts.

LIMNOLOGY AND OCEANOGRAPHY (2022)

添加到收藏夹

Article Chemistry, Physical

Interface tweaking of perovskite solar cells with carbon nitride-based 2D materials

Naveen Harindu Hemasiri, Muhammad Ashraf, Samrana Kazim, Robert Graf, Nisar Ullah, Muhammad Nawaz Tahir, Shahzada Ahmad

Summary: Two-dimensional van der Waals layered materials exhibit strong Coulomb interactions, leading to large exciton binding energies. Tuning the interface is crucial for device functionality, including optoelectrical devices.

NANO ENERGY (2023)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Tweaking the bridge in metallocene Zr(iv)/W(iv) bimetallic hydrides

Selwin Fernando, Martina Landrini, Alceo Macchioni, David L. L. Hughes, Peter H. M. Budzelaar, Luca Rocchigiani

Summary: Zirconocene cations react with Cp2WH2 to form bimetallic bridging hydride 1, which has an atypical Zr(mu-H)W structure and a modulatable coordination geometry. Reaction with Lewis bases and unsaturated substrates can shift the coordination plane of the hydride bridge. Reaction with olefins and alkynes leads to alkyl and vinyl species with perpendicular Zr and W coordination planes. The bridging hydride interaction prevents bimetallic cooperativity and sigma-bond metathesis between Zr-C and H-H bonds is the preferred pathway.

DALTON TRANSACTIONS (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals

Frederic B. Bastian, Julien Roux, Anne Niknejad, Aurelie Comte, Sara S. Fonseca Costa, Tarcisio Mendes de Farias, Sebastien Moretti, Gilles Parmentier, Valentine Rech de Laval, Marta Rosikiewicz, Julien Wollbrett, Amina Echchiki, Angelique Escoriza, Walid H. Gharib, Mar Gonzales-Porta, Yohan Jarosz, Balazs Laurenczy, Philippe Moret, Emilie Person, Patrick Roelli, Komal Sanjeev, Mathieu Seppey, Marc Robinson-Rechavi

Summary: Bgee is a database that allows retrieval and comparison of gene expression patterns in multiple animal species using curated healthy wild-type data, enabling the detection of expression conditions for any single gene across different species. It integrates various data types and ensures consistent data annotation and processing for cross-species comparisons.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Chemistry, Physical

Tweaking the interplay of the layers by substitution in Ca3Co4O9+δ for high efficiency thermoelectric materials

Sivakumar Neelakandan, Krishnendu Biswas

Summary: In this study, the electrical conductivity and power factor of Ca3Co4O9 were enhanced by doping, while the thermal conductivity remained unchanged. This is of great significance for improving the thermoelectric performance of the material.

JOURNAL OF ALLOYS AND COMPOUNDS (2024)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tweaking the Small Non-Coding RNAs to Improve Desirable Traits in Plant

Koushik Halder, Abira Chaudhuri, Malik Z. Abdin, Asis Datta

Summary: The plant transcriptome contains a large number of non-coding RNAs (ncRNAs) which play a role in regulating gene expression. These ncRNAs have been extensively studied since the 1990s to understand their function in gene regulatory networks and their involvement in plant responses to various stresses. Small ncRNAs, such as siRNAs, miRNAs, and tasiRNAs, are of particular interest to molecular breeders due to their agricultural importance. This review provides an overview of the current knowledge on these small ncRNAs, including their biogenesis, mode of action, and their potential use in improving crop productivity and disease resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Article Agronomy

Tweaking Pakistani Punjab rice-wheat management to maximize productivity within nitrate leaching limits

Donald S. Gaydon, Tasneem Khaliq, Mobin-ud-Din Ahmad, M. J. M. Cheema, Umair Gull

Summary: Pakistan is facing challenges of food insecurity and water scarcity. Research suggests that significant gains in rice and wheat production can be achieved through optimizing farmer management strategies, particularly in crop planting and fertilizer use, to improve productivity and water resource efficiency.

FIELD CROPS RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Our shared global responsibility: Safeguarding crop diversity for future generations

Hannes Dempewolf, Sarada Krishnan, Luigi Guarino

Summary: The resilience and sustainability of food systems rely on crop diversity, which is used by breeders and farmers to produce new varieties and respond to challenges. To meet changing demands, the global conservation system for crop diversity needs to keep pace by providing both biological materials and relevant information, while ensuring equitable access and benefit sharing.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

添加到收藏夹

Article Environmental Sciences

The principles driving gene drives for conservation

Sarah Hartley, Riley Taitingfong, Pedro Fidelman

Summary: Gene drive technology is an emerging biotechnology that has the potential to address global biodiversity conservation issues. The governance of conservation gene drive involves principles such as broad engagement, public acceptance, informed decision-making, collaboration, ethical frameworks, diverse expertise, and developer self-regulation. Analyzing these principles helps to understand the goals and responsibilities of gene drive applications in conservation and evaluate their strengths and weaknesses.

ENVIRONMENTAL SCIENCE & POLICY (2022)

添加到收藏夹

Article Chemistry, Physical

Atypical performance of CoO-accelerated interface tweaking in hierarchical cobalt phosphide/oxide@P-doped rGO heterostructures for hybrid supercapacitors

Paulraj Arunkumar, Sampath Gayathri, Dipankar Saha, Jong Hun Han

Summary: In this study, a 2D/2D heterostructure made of hierarchical pseudocapacitive cobalt phosphide/oxide and P-doped reduced graphene oxide (PrGO) nanosheets (CoP/CoO@PrGO) was fabricated using porous zeolitic-imidazolate framework precursor. This structure exhibits a high specific capacitance of 405 F g-1 at 5 A g-1 and excellent cycling stability. Therefore, this heterostructure holds great potential for the development of high-performance supercapacitors.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

添加到收藏夹

Article Biodiversity Conservation

Impacts of climate change and renewable energy development on habitat of an endemic squirrel, Xerospermophilus mohavensis, in the Mojave Desert, USA

Richard D. Inman, Todd C. Esque, Kenneth E. Nussear, Philip Leitner, Marjorie D. Matocq, Peter J. Weisberg, Thomas E. Dilts

BIOLOGICAL CONSERVATION (2016)

添加到收藏夹

Article Ecology

Landscape disturbance and sporadic hybridization complicate field identification of chipmunks

Christina F. Frare, Marjorie D. Matocq, Chris R. Feldman, Angela M. White, Patricia N. Manley, Kathleen D. Jermstad, Evon R. Hekkala

JOURNAL OF WILDLIFE MANAGEMENT (2017)

添加到收藏夹

Article Neurosciences

Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations

Gaurav Kaushik, Yu Xia, Jean C. Pfau, Michael A. Thomas

NEUROSCIENCE LETTERS (2017)

添加到收藏夹

Review Ecology

Biodiversity and Topographic Complexity: Modern and Geohistorical Perspectives

Catherine Badgley, Tara M. Smiley, Rebecca Terry, Edward B. Davis, Larisa R. G. DeSantis, David L. Fox, Samantha S. B. Hopkins, Tereza Jezkova, Marjorie D. Matocq, Nick Matzke, Jenny L. McGuire, Andreas Mulch, Brett R. Riddle, V. Louise Roth, Joshua X. Samuels, Caroline A. E. Stroemberg, Brian J. Yanites

TRENDS IN ECOLOGY & EVOLUTION (2017)

添加到收藏夹

Article Biodiversity Conservation

GENETIC STRUCTURE ACROSS A CONTACT ZONE BETWEEN XEROSPERMOPHILUS GROUND SQUIRRELS IN SOUTHERN CALIFORNIA

Philip Leitner, Jennifer Rippert, Marjorie D. Matocq

WESTERN NORTH AMERICAN NATURALIST (2017)

添加到收藏夹

Article Zoology

Genetically distinct populations of the pygmy rabbit (Brachylagus idahoensis) in the Mono Basin of California

Eveline S. Larrucea, Morgan L. Robinson, Jennifer S. Rippert, Marjorie D. Matocq

JOURNAL OF MAMMALOGY (2018)

添加到收藏夹

Article Evolutionary Biology

The genetic legacy of 50 years of desert bighorn sheep translocations

Joshua P. Jahner, Marjorie D. Matocq, Jason L. Malaney, Mike Cox, Peregrine Wolff, Mitchell A. Gritts, Thomas L. Parchman

EVOLUTIONARY APPLICATIONS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

The potential association of psychoactive pharmaceuticals in the environment with human neurological disorders

Gaurav Kaushik, Michael A. Thomas

SUSTAINABLE CHEMISTRY AND PHARMACY (2019)

添加到收藏夹

Article Biodiversity Conservation

Can long-lived species keep pace with climate change? Evidence of local persistence potential in a widespread conifer

Sarah M. Bisbing, Alexandra K. Urza, Brian J. Buma, David J. Cooper, Marjorie Matocq, Amy L. Angert

Summary: The study highlights the impact of landscape on genetic structure and performance of tree populations, with local climate conditions influencing survival and growth patterns. Some populations may not currently occupy their climatic optimum, but genetically diverse and phenotypically plastic populations of trees have high persistence potential.

DIVERSITY AND DISTRIBUTIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multigenerational backcrossing and introgression between two woodrat species at an abrupt ecological transition

Joshua P. Jahner, Thomas L. Parchman, Marjorie D. Matocq

Summary: Analysis of genetic data from two ecologically distinct mammals in a hybrid zone in southern California shows that hybrids are rare and consist mostly of F-1 individuals and multigenerational backcrosses. More than half of loci show elevated introgression from one genetic background to the other, although introgression is not associated with measures of divergence and loci with extreme divergence values are not near detoxification enzymes related to woodrat dietary specialization.

MOLECULAR ECOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trio-binned genomes of the woodrats Neotoma bryanti and Neotoma lepida reveal novel gene islands and rapid copy number evolution of xenobiotic metabolizing genes

Robert Greenhalgh, Matthew L. Holding, Teri J. Orr, James B. Henderson, Thomas L. Parchman, Marjorie D. Matocq, Michael D. Shapiro, M. Denise Dearing

Summary: The genomic architecture of woodrats and their response to environmental change, especially the switch to a toxic food source, are studied using third-generation sequencing and novel analytical toolsets. A trio binning sequencing approach with a hybrid woodrat allows the simultaneous assembly of genomes representing each parental species, providing insights into the genetic mechanisms of dietary adaptation. Multiple gene duplications and expansions in key gene families involved in the metabolism of toxic compounds are found, suggesting the crucial role of these genetic changes in dietary adaptation. The success of trio binning in recovering parental genomes from species that diverged millions of years ago is also demonstrated.

MOLECULAR ECOLOGY RESOURCES (2022)

添加到收藏夹

Article Ecology

Hybridization in the absence of an ecotone favors hybrid success in woodrats (Neotoma spp.)

Dylan M. Klure, Robert Greenhalgh, Thomas L. Parchman, Marjorie D. Matocq, Lanie M. Galland, Michael D. Shapiro, M. Denise Dearing

Summary: In a shrubland in California, a 3-year recapture study on Bryant's woodrat and desert woodrat revealed a high frequency of hybridization. The hybrids have comparable survival rates to the dominant parental species, indicating that ecological factors have limited influence on hybridization in this environment.

EVOLUTION (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential Effects of Climate on Survival Rates Drive Hybrid Zone Movement

Elizabeth A. Hunter, Marjorie D. Matocq, Peter J. Murphy, Kevin T. Shoemaker

CURRENT BIOLOGY (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Predicting genome terminus sequences of Bacillus cereus-group bacteriophage using next generation sequencing data

Cheng-Han Chung, Michael H. Walter, Luobin Yang, Shu-Chuan (Grace) Chen, Vern Winston, Michael A. Thomas

BMC GENOMICS (2017)

添加到收藏夹

Meeting Abstract Chemistry, Multidisciplinary

Neurodevelopmental toxicity of low concentration silver nanoparticles in embryonic zebrafish (Danio rerio)

Tyler Hemphill, Verona Nicolae, Alicia Latta, Stephen Robertson, Russ Manteca, Cecelia Pena, Joshua Pak, Michael Thomas, Jerry Harris

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.