Article
Multidisciplinary Sciences
Darlan C. Minussi, Michael D. Nicholson, Hanghui Ye, Alexander Davis, Kaile Wang, Toby Baker, Maxime Tarabichi, Emi Sei, Haowei Du, Mashiat Rabbani, Cheng Peng, Min Hu, Shanshan Bai, Yu-wei Lin, Aislyn Schalck, Asha Multani, Jin Ma, Thomas O. McDonald, Anna Casasent, Angelica Barrera, Hui Chen, Bora Lim, Banu Arun, Funda Meric-Bernstam, Peter Van Loo, Franziska Michor, Nicholas E. Navin
Summary: Breast tumors and cell lines consist of numerous subclones organized into a few major superclones. Following clonal TP53 mutations, loss-of-heterozygosity events, and genome doubling, primary tumors undergo a period of transient genomic instability, with ongoing copy number evolution during expansion. Subcloned daughter cells demonstrate genomic rediversification, showing that triple-negative breast cancers continually evolve chromosome aberrations and maintain subclonal diversity during primary tumor growth.
Article
Multidisciplinary Sciences
Johann S. Bergholz, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G. Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J. Freeman, Hye-Jung Kim, Alex K. Shalek, Thomas M. Roberts, Jean J. Zhao
Summary: In this study, it was found that genetic inactivation of PI3K beta can induce anti-tumor immune responses and inhibit the growth of PTEN-deficient breast cancer. This effect is associated with reduced STAT3 signaling and increased expression of immune stimulatory molecules. Pharmacological inhibition of PI3K beta also elicits anti-tumor immunity and synergizes with immunotherapy to inhibit tumor growth. Therefore, the combination of PI3K beta inhibitors and immunotherapy may be a rational treatment approach for PTEN-deficient breast cancer.
Review
Clinical Neurology
James A. R. Nicoll, Tabitha Bloom, Amelia Clarke, Delphine Boche, David Hilton
Summary: BRAIN UK aims to provide extensive archives of neurological tissues and tumors to support neuroscience research. The organization has successfully integrated most of the regional clinical neuroscience centers in the UK to establish a centralized archive database. Researchers can easily access these archives through a simple application process.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Physics, Multidisciplinary
Thomas Fuhs, Franziska Wetzel, Anatol W. Fritsch, Xinzhi Li, Roland Stange, Steve Pawlizak, Tobias R. Kiessling, Erik Morawetz, Steffen Grosser, Frank Sauer, Juergen Lippoldt, Frederic Renner, Sabrina Friebe, Mareike Zink, Klaus Bendrat, Juergen Braun, Maja H. Oktay, John Condeelis, Susanne Briest, Benjamin Wolf, Lars-Christian Horn, Michael Hoeckel, Bahriye Aktas, M. Cristina Marchetti, M. Lisa Manning, Axel Niendorf, Dapeng Bi, Josef A. Kaes
Summary: Cancer cells within tumors tend to become softer, and primary tumors exhibit high mechanical heterogeneity across scales, providing stability and room for cell motility.
Article
Business, Finance
Theophilus Lartey, Gregory A. James, Albert Danso
Summary: This study proposes a novel approach to examine the impact of bank risk exposures on bank efficiency levels, showing that good bank performance management depends on the alliance between risk, funding, and financial performance. High financial or overall performance may not necessarily lead to better risk management, indicating that banks are inherently performance-driven institutions with independent optimal performance objectives.
INTERNATIONAL REVIEW OF FINANCIAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Jan Meiners, Kristina Jansen, Natalia Gorbokon, Franziska Buescheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Doris Hoeflmayer, Soeren Weidemann, Christoph Fraune, Katharina Moeller, Christian Bernreuther, Patrick Lebok, Anne Menz, Frank Jacobsen, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Jakob Izbicki, Daniel Perez, Sarah Minner, Eike Burandt, Till Krech, Andreas Marx, Ronald Simon, Stefan Steurer
Summary: ACE2 expression is detected in tumor cells and tumor-associated capillaries of various tumor types, with particularly high frequencies in certain cancers such as renal cell carcinoma and colorectal adenocarcinoma.
Article
Pathology
Wenping Shen, Qun Han, Feifei Sun, Zhishuang Li, Li Li
Summary: Nek9 has high expression in schwannomas, melanomas, and rhabdomyosarcomas, with relatively high positivity in neurofibromas and MPNSTs. It has better sensitivity compared to S-100 and SOX10. Immunohistochemical analysis of Nek9 expression may aid in the diagnosis and differential diagnosis of these tumors.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Chemistry, Analytical
Carolina Blanco-Angulo, Andrea Martinez-Lozano, Roberto Gutierrez-Mazon, Carlos G. Juan, Hector Garcia-Martinez, Julia Arias-Rodriguez, Jose M. Sabater-Navarro, Ernesto Avila-Navarro
Summary: This study introduces a microwave-based non-invasive system for detecting tumors in breast phantoms. The system includes hardware and software components, allowing for automated data acquisition and the generation of medical images using an improved algorithm. Experimental results demonstrate the system's effectiveness in detecting tumors in the breast.
Article
Engineering, Biomedical
Karolyn Sassi Ogliari, Patricia Bencke Grudzinski, Camila Gomes da Silva, Monica Luiza Immig, Maria Laura Halon, Fabrizio Blank Loth, Alicia Sassi Ogliari, Monique Blauth Tovo, Liziane Raquel Beckenkamp
Summary: This study presents a validated protocol for long-term preservation of amniotic membrane (AM) and demonstrates its effectiveness in maintaining the tissue's cell viability and biological properties. Cryopreservation with dimethyl sulfoxide and product presentation as a multilayer roll showed the best results, and the tissue could be kept under refrigerated conditions for up to 7 days with acceptable cell viability.
BIOMEDICAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Gameel Saleh, Ashraf Abuelhaija, Budour Alfaris, Aljohara Aljabr, Maryam Zainalabedin, M. H. A. Mhareb, Maryam Alhashim, Salma Alenezi
Summary: In this article, a heterogeneous multimodal anthropomorphic breast phantom with carcinoma is developed to mimic the response of the natural breast tissue when imaged using ionizing and non-ionizing machines. The phantom is tailored in terms of its elemental composition and response to ionization radiation parameters. The fabricated phantom shows an excellent agreement with the properties of the natural breast tissue. Experimental validation using CT, MRI, and Mammographic machines confirms the accuracy of the phantom's imaging properties.
Review
Cell & Tissue Engineering
Bao-Shi Fan, Yang Liu, Ji-Ying Zhang, You-Rong Chen, Meng Yang, Jia-Kuo Yu
Summary: The study summarized the 5C basic principles for establishing modern standardized stem cell banks and discussed the applications of stem cells in managing sports injuries. Proposing these principles will benefit in standardizing stem cell research and establishing modern stem cell banks, while the establishment of stem cell banks can help the scientific community cope with the difficulty of obtaining stem cell samples.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pathology
Melinda F. Lerwill, Andrew H. S. Lee, Puay Hoon Tan
Summary: Fibroepithelial tumors of the breast consist of fibroadenomas and phyllodes tumors, which have distinct pathological features and grading. Phyllodes tumors have the potential for recurrence, and malignant cases may metastasize and lead to death.
Article
Pathology
Fresia Pareja, Mahsa Vahdatinia, Caterina Marchio, Simon S. K. Lee, Arnaud Da Cruz Paula, Fatemeh Derakhshan, Edaise M. da Silva, Pier Selenica, Higinio Dopeso, Sarat Chandarlapaty, Hannah Y. Wen, Anne Vincent-Salomon, Edi Brogi, Britta Weigelt, Jorge S. Reis-Filho
Summary: Breast neuroendocrine tumors (NETs) have genetic similarities with mucinous breast carcinomas (MuBCs), characterized by an enrichment of mutations in transcription factors. These findings suggest that some breast cancers may acquire neuroendocrine differentiation later in tumor evolution.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Yunju Kim, Sung Hoon Sim, Boram Park, In Hye Chae, Jai Hong Han, So-Youn Jung, Seeyoun Lee, Youngmi Kwon, In Hae Park, Kyounglan Ko, Chan Wha Lee, Keun Seok Lee, Han-Sung Kang, Eun Sook Lee
Summary: The study investigated the use of MRI criteria to identify residual tumors in patients with triple-negative and HER2+ breast cancer following neoadjuvant chemotherapy. Different parameters showed varying diagnostic performances in distinguishing residual tumors in different subtypes of breast cancer. The results suggest that MRI-based identification of residual tumors is feasible in selected patients.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Barbara Blanco-Fernandez, Sergi Rey-Vinolas, Gulsun Bagci, Gerard Rubi-Sans, Jorge Otero, Daniel Navajas, Soledad Perez-Amodio, Elisabeth Engel
Summary: Breast tissue-derived matrices can serve as important biomaterials to replicate the complexity of the tumor extracellular matrix (ECM), with the addition of collagen type I improving the fidelity to breast tumors. These novel bioinks have great potential in bioprinting breast cancer models.
ACS APPLIED MATERIALS & INTERFACES
(2022)