X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

(2010) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

(2010) H. Nury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

(2009) Yun Weng et al.   ANESTHESIA AND ANALGESIA

Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems

(2009) Hongmin Zhang et al.   FASEB JOURNAL

A Unitary Anesthetic Binding Site at High Resolution

(2009) L. Sangeetha Vedula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anionic Lipids Allosterically Modulate Multiple Nicotinic Acetylcholine Receptor Conformational Equilibria

(2009) Corrie J. B. daCosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor  1M1- 2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

(2009) M. Bali et al.   JOURNAL OF NEUROSCIENCE

Functional Complementation of Glra1spd-ot, a Glycine Receptor Subunit Mutant, by Independently Expressed C-Terminal Domains

(2009) C. Villmann et al.   JOURNAL OF NEUROSCIENCE

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

(2009) Svenja Haeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of Nicotinic Acetylcholine Receptor Conformational State by Free Fatty Acids and Steroids

(2008) Gaspar A. Fernández Nievas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

(2008) Nicholas P. Franks   NATURE REVIEWS NEUROSCIENCE