Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Immunology
Daniel V. Lopez, Fatima A. H. Al-Jaberi, Nkerorema D. Damas, Brian T. Weinert, Urska Pus, Sara Torres-Rusillo, Anders Woetmann, Niels Odum, Charlotte M. Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Th22 cells are a CD4(+) T cell subset that produces interleukin (IL)-22 and primarily acts on epithelial cells, affecting keratinocyte proliferation, differentiation, and maturation. The regulation of IL-22 production in human T cells involves the transcription factors AhR and ROR gamma t, as well as the active form of vitamin D-3. The inhibition of IL-22 production by 1,25(OH)(2)D-3 through VDR and VDRE has been identified as a key mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Souzana E. Xyda, Kalliopi Kotsa, Argyrios Doumas, Emmanouil Papanastasiou, Alexandros A. Garyfallos, George Samoutis
Summary: The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries, Greece and Cyprus, despite ample sunlight in the region. Only the month and gender were significantly associated with vitamin D levels.
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Siekkeri Vandikas, Kerstin Landin-Wilhelmsen, Martin Gillstedt, Amra Osmancevic
Summary: In patients with psoriasis, high levels of vitamin D-binding protein (DBP) may serve as a new inflammatory biomarker. Total 25(OH)D is a reliable measure for vitamin D status in psoriasis patients, but evaluation of free 25(OH)D levels should be considered in patients with multiple co-morbidities and/or undergoing biologic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Linnea Huss, Salma Tuna Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Jonas Manjer, Ann Rosendahl
Summary: This study found no association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality.
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Review
Nutrition & Dietetics
Karina Piatek, Martin Schepelmann, Enikoe Kallay
Summary: Ovarian cancer is a deadly cancer in women, but the current treatments have debilitating side effects. Therefore, there is a need for new treatments with fewer side effects. Vitamin D has anticancer effects, but high doses cause hypercalcemia. Researchers are looking for analogs of vitamin D to reduce side effects.
Review
Nutrition & Dietetics
Andreea Bianca Stoica, Claudiu Marginean
Summary: This article reviews the impact of vitamin D deficiency on the health of infants, emphasizing its global significance and the need for further research and strategies. While conflicting results exist regarding the effects of vitamin D, it is clear that deficiency has significant implications, particularly for infants.
Review
Pharmacology & Pharmacy
Carsten Carlberg, Eunike Velleuer
Summary: Low vitamin D status is a risk factor for colon, prostate, breast, and leukocyte cancers. Lifestyle adjustments can help control cancer risk. Vitamin D has anti-cancer effects on neoplastic cells and immune cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Usama, Zahid Khan, Aktar Ali, Masaud Shah, Muhammad Imran
Summary: Vitamin D (VD) can be produced by the skin or obtained from diet, and deficiency of VD is associated with various risk factors including mutations and modifications in its transport protein VDBP or GC-globulin. Two common single nucleotide polymorphisms create three isoforms of VDBP, and the study investigates the effect of these mutations on conformational changes and VD-binding affinity. The findings reveal the importance of glycation in stabilizing the protein structure and propose a novel mechanism in how distant mutations affect the VD interaction with VDBP.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Immunology
Lori A. Plum, William Blaser, Logan Peter, Jean Prahl, Jeremy Seeman, Hector F. DeLuca
Summary: The study found that vitamin D is not necessary for producing antibodies, as neither vitamin D deficiency, absence of the vitamin D receptor, nor hypocalcemia affected the ability of mice to mount an antibody response to an antigen challenge.
FRONTIERS IN IMMUNOLOGY
(2022)