Cancer: The flipside of Notch

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

(2011) Zhenyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

(2010) Jon C Aster et al.   JOURNAL OF PATHOLOGY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

(2008) Shadmehr Demehri et al.   PLOS BIOLOGY