Review
Genetics & Heredity
Lei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng, Erwei Hao
Summary: As a neurodegenerative disease, Alzheimer's disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Epitranscriptomic modifications, such as m6A modification, play a significant role in the development of AD. This paper reviews the advances in understanding the regulatory mechanisms of m6A modification in the occurrence and development of AD, and discusses the research techniques related to animal models of m6A and AD, as well as the potential of studying the pathogenesis of AD at the level of the epitranscriptome and identifying early diagnostic markers and effective treatment options.
FRONTIERS IN GENETICS
(2023)
Review
Psychology, Clinical
Reinout W. Wiers, Paul Verschure
Summary: The dominant biomedical perspective views addiction as chronic brain diseases, but this broken brain model has limitations. A systems-level perspective is proposed to better capture the development of addiction and its dynamic influence on subsequent brain adaptations.
ADDICTIVE BEHAVIORS
(2021)
Article
Pharmacology & Pharmacy
Muhammad Usman Haider, Muhammad Furqan, Qasim Mehmood
Summary: The FDA has approved daprodustat as the first oral treatment option for anemia in CKD dialysis patients. Clinical trials have shown its efficacy and safety, non-inferior to darbepoetin and potentially reducing IV iron usage. Daprodustat also holds potential for treating anemia in non-dialysis patients with CKD and for patients with both renal anemia and heart failure, pending further research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Management
Nuno A. Gil
Summary: Megaprojects are complex endeavors that often face challenges such as delays, budget overruns, and scope expansion. This essay suggests that drawing on a new stakeholder theory can help understand and address these issues. Insights from ongoing research show that managers and sponsors face dilemmas in balancing normative traditions and value distribution with essential stakeholders. It is important to study the incentives behind strategic choices made before and after capital investment, and explore ways to achieve socially valuable outcomes.
INTERNATIONAL JOURNAL OF PROJECT MANAGEMENT
(2023)
Review
Endocrinology & Metabolism
Patrycja Mulica, Anne Gruenewald, Sandro L. Pereira
Summary: Declining brain energetics play a role in aging and neurodegenerative diseases like Alzheimer's and Parkinson's. Recent evidence suggests that astrocytes, key in supporting neuronal function, may also contribute to the development of these diseases. Understanding the metabolic interactions between astrocytes and neurons, particularly regarding mitochondria, has therapeutic potential in addressing neurodegenerative disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Kamran Badizadegan, Dominika A. Kalkowska, Kimberly M. Thompson
Summary: This study estimates the number of paralytic polio cases prevented by polio vaccines and the Global Polio Eradication Initiative (GPEI). The results show that the existence and use of polio vaccines have prevented millions of cases globally, and the GPEI has further reduced the number of cases. Analyzing historical cases provides important context for understanding the benefits of investments made in polio eradication.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Chiara Moltrasio, Paola Maura Tricarico, Maurizio Romagnuolo, Angelo Valerio Marzano, Sergio Crovella
Summary: This article provides an overview of the contribution of various genetic studies in the field of Hidradenitis Suppurativa (HS) and discusses the role of genetics in HS, as well as the application of next-generation sequencing technologies.
Article
Clinical Neurology
Anna G. M. Temp, Alexander Ly, Johnny van Doorn, Eric-Jan Wagenmakers, Yi Tang, Michael W. Lutz, Stefan Teipel
Summary: This article introduces the application of Bayesian analysis in clinical trials, using the data of aducanumab as an example. Bayesian analysis can quantify evidence and assess the strength of the effect, which is different from the binary conclusions provided by frequentist tests.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cardiac & Cardiovascular Systems
Veronique L. Roger
Summary: This review summarizes recent studies on the epidemiology of heart failure (HF) over the past decade, indicating that while the incidence of HF is mostly flat or declining, the burden of mortality and hospitalization remains significant, especially with major disparities among younger Black men and women. Emerging risk factors and holistic management approaches may help improve the treatment and management of HF.
CIRCULATION RESEARCH
(2021)
Article
Computer Science, Artificial Intelligence
Anthony Thomas, Sanjoy Dasgupta, Tajana Rosing
Summary: Hyperdimensional computing is a neurally inspired method to obtain high-dimensional, low-precision, distributed data representations. These representations, when combined with simple algorithms, can perform various information processing tasks effectively. This approach has garnered significant interest for its energy-efficient, low-latency, and noise-robust capabilities in solving learning problems.
JOURNAL OF ARTIFICIAL INTELLIGENCE RESEARCH
(2021)
Review
Nutrition & Dietetics
Mitsutaka Nakashima, Kazufumi Nakamura, Takahiro Nishihara, Keishi Ichikawa, Rie Nakayama, Yoichi Takaya, Norihisa Toh, Satoshi Akagi, Toru Miyoshi, Teiji Akagi, Hiroshi Ito
Summary: Cardiovascular diseases and liver diseases are closely related, with non-alcoholic fatty liver disease having the same risk factors as atherosclerotic cardiovascular disease. Heart failure leads to liver fibrosis, worsening cardiac preload and congestion. The association between cardiovascular diseases and liver disease is reviewed, highlighting the importance of assessing liver fibrosis as a prognostic marker and the need for future investigations.
Review
Biochemistry & Molecular Biology
Carlo Albera, Giulia Verri, Federico Sciarrone, Elena Sitia, Mauro Mangiapia, Paolo Solidoro
Summary: Interstitial lung diseases (ILDs) encompass a diverse group of rare and chronic respiratory disorders, with idiopathic pulmonary fibrosis (IPF) being the most studied member. Recent development of antifibrotic drugs has shown benefits in ILDs characterized by progressive fibrosis, leading to significant changes in management.
Article
Engineering, Environmental
Ufuk Alpsahin Cullen, Roberta De Angelis
Summary: The circular economy, inspired by the efficient resource utilization in ecosystems, proposes more efficient production and consumption patterns. Circular entrepreneurship involves exploring and exploiting opportunities in the circular economy domain, emphasizing value creation and social responsibility.
RESOURCES CONSERVATION AND RECYCLING
(2021)
Article
Biochemistry & Molecular Biology
Eberhard Passarge
Summary: Genetics as a field of science evolved after 1900, with human genetics tracing its origins to the period between 1949 and 1959. Scientific advances since 1949 have led to precise genetic diagnoses for many human diseases, genetic counseling, and the integration of genetics into medicine, making human genetics a fundamental area in both medical and biological sciences.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Review
Genetics & Heredity
Shahidee Zainal Abidin, Nurul Asykin Mat Pauzi, Nur Izzati Mansor, Nurul Iffah Mohd Isa, Adila A. Hamid
Summary: microRNAs (miRNAs) and circular RNAs (circRNAs) play important roles in the pathogenesis of Alzheimer's disease, regulating various aspects of the disease progression. The dynamic interaction between miRNAs and their target genes depends on factors such as subcellular localization, relative abundance, and affinity of miRNA-mRNA interactions. CircRNAs, on the other hand, regulate gene expression through interaction with miRNAs at the transcriptional or post-transcriptional level. Although their precise functions and mechanisms are not fully understood, miRNAs and circRNAs have potential importance in the diagnosis and treatment of Alzheimer's disease.
FRONTIERS IN GENETICS
(2023)
Article
Hematology
Shannon R. McCurdy, Stephen T. Muth, Hua-Ling Tsai, Heather J. Symons, Carol Ann Huff, William H. Matsui, Ivan Borrello, Douglas E. Gladstone, Lode J. Swinnen, Kenneth R. Cooke, Robert A. Brodsky, Javier Bolanos-Meade, Richard F. Ambinder, Ravi Varadhan, Leo Luznik, Richard J. Jones, Maria P. Bettinot, Ephraim J. Fuchs
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Hematology
Toshihiko Tanno, Yiting Lim, Qiuju Wang, Marta Chesi, P. Leif Bergsagel, Geoff Matthews, Ricky W. Johnstone, Nilanjan Ghosh, Ivan Borrello, Carol Ann Huff, William Matsui
Article
Oncology
Ravi K. Anchoori, Balasubramanyam Karanam, Shiwen Peng, Joshua W. Wang, Rosie Jiang, Toshihiko Tanno, Robert Z. Orlowski, William Matsui, Ming Zhao, Michelle A. Rudek, Chien-fu Hung, Xiang Chen, Kylie J. Walters, Richard B. S. Roden
Article
Oncology
Grace M. Wang, Hong Yuen Wong, Hiroyuki Konishi, Brian G. Blair, Abde M. Abukhdeir, John P. Gustin, D. Marc Rosen, Samuel Ray Denmeade, Zeshaan Rasheed, William Matsui, Joseph P. Garay, Morassa Mohseni, Michaela J. Higgins, Justin Cidado, Danijela Jelovac, Sarah Croessmann, Rory L. Cochran, Sivasundaram Karnan, Yuko Konishi, Akinobu Ota, Yoshitaka Hosokawa, Pedram Argani, Josh Lauring, Ben Ho Park
Article
Gastroenterology & Hepatology
Jennifer M. Bailey, Janivette Alsina, Zeshaan A. Rasheed, Florencia M. McAllister, Ya-Yuan Fu, Ruben Plentz, Hao Zhang, Pankaj J. Pasricha, Nabeel Bardeesy, William Matsui, Anirban Maitra, Steven D. Leach
Letter
Allergy
Jenny H. Lin, William Matsui, Charles Aloe, Roger D. Peng, Gregory B. Diette, Patrick N. Breysse, Elizabeth C. Matsui
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Allergy
Corinne A. Keet, Wayne G. Shreffler, Roger D. Peng, William Matsui, Elizabeth C. Matsui
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Article
Medicine, Research & Experimental
Jung-Hyun Kim, Rajesh K. Thimmulappa, Vineet Kumar, Wanchang Cui, Sarvesh Kumar, Ponvijay Kombairaju, Hao Zhang, Joseph Margolick, William Matsui, Thomas Macvittie, Sanjay V. Malhotra, Shyam Biswal
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Oncology
Yvette L. Kasamon, Robert A. Brodsky, Michael J. Borowitz, Richard F. Ambinder, Pamela A. Crilley, Steve Y. Cho, Hua-ling Tsai, B. Douglas Smith, Douglas E. Gladstone, Hetty E. Carraway, Carol Ann Huff, William H. Matsui, Javier Bolanos-Meade, Richard J. Jones, Lode J. Swinnen
LEUKEMIA & LYMPHOMA
(2013)
Article
Oncology
Joshua F. Zeidner, Douglas E. Gladstone, Marianna Zahurak, William H. Matsui, Christopher Gocke, Richard J. Jones, B. Douglas Smith
Article
Oncology
Jasmin R. Agarwal, Qiuju Wang, Toshihiko Tanno, Zeshaan Rasheed, Akil Merchant, Nilanjan Ghosh, Ivan Borrello, Carol Ann Huff, Farhad Parhami, William Matsui
MOLECULAR CANCER THERAPEUTICS
(2014)
Review
Respiratory System
Muhammad Alamgeer, Craig D. Peacock, William Matsui, Vinod Ganju, D. Neil Watkins
Article
Oncology
Filipe L. F. Carvalho, Brian W. Simons, Emmanuel S. Antonarakis, Zeshaan Rasheed, Nora Douglas, Daniela Villegas, William Matsui, David M. Berman
Review
Oncology
Ajay Abraham, William Matsui
Summary: Myeloid malignancies arise from normal hematopoiesis and the Hedgehog (HH) signaling pathway plays an important role in these diseases, with SMO inhibitors approved for the treatment of acute myeloid leukemia (AML). Despite the broad activity of SMO inhibitors in AML, clinical studies in other myeloid malignancies remain inconclusive and further research is needed to explore their efficacy.
Article
Hematology
Nilanjan Ghosh, Xiaobu Ye, Hua-Ling Tsai, Javier Bolanos-Meade, Ephraim J. Fuchs, Leo Luznik, Lode J. Swinnen, Douglas E. Gladstone, Richard F. Ambinder, Ravi Varadhan, Satish Shanbhag, Robert A. Brodsky, Ivan M. Borrello, Richard J. Jones, William Matsui, Carol Ann Huff
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
