Article
Clinical Neurology
Alexis M. Crockett, Sean K. Ryan, Adriana Hernandez Vasquez, Caroline Canning, Nickole Kanyuch, Hania Kebir, Guadalupe Ceja, James Gesualdi, Elaine Zackai, Donna McDonald-McGinn, Angela Viaene, Richa Kapoor, Nail Benallegue, Raquel Gur, Stewart A. Anderson, Jorge Alvarez
Summary: Neuroimmune dysregulation is implicated in neuropsychiatric disorders, including schizophrenia. Research found compromised vascular phenotype in patients with 22q11.2 deletion syndrome, leading to compromised immune privilege and potentially increased risk of neuropsychiatric disease.
Article
Psychology, Biological
Tzvetan Popov, Brigitte Rockstroh, Gregory A. Miller
Summary: This study found that individuals with schizophrenia exhibit poorer sensory gating, particularly in the A1 region, as well as in adjacent brain regions. In addition, the study suggests that endogenous connectivity evident in a sequence of activity from angular gyrus to portions of superior temporal gyrus may contribute to both normal and abnormal gating in schizophrenia.
Article
Neurosciences
Xiaotong Du, Xiaotong Wei, Hao Ding, Ying Yu, Yingying Xie, Yi Ji, Yu Zhang, Chao Chai, Meng Liang, Jie Li, Chuanjun Zhuo, Chunshui Yu, Wen Qin
Summary: Functional connectivity disruption is a significant characteristic of schizophrenia, but the heterogeneity of patterns reported across different sites has hindered its clinical generalization. This study compared different correction methods and identified three replicable subnets of disrupted functional connectivities in schizophrenia patients.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Lucie Berkovitch, Lucie Charles, Antoine Del Cul, Nora Hamdani, Marine Delavest, Samuel Sarrazin, Jean-Francois Mangin, Pamela Guevara, Ellen Ji, Marc-Antoine D'albis, Raphael Gaillard, Frank Bellivier, Cyril Poupon, Marion Leboyer, Ryad Tamouza, Stanislas Dehaene, Josselin Houenou
Summary: According to the global neuronal workspace (GNW) theory, conscious access relies on long-distance cerebral connectivity. This study aimed to determine the correlation between structural connectivity and consciousness threshold in psychosis. Results showed that patients with psychosis had an elevated masking threshold compared to controls, with alterations in long-distance connectivity associated with increased masking threshold and psychotic symptoms. The findings suggest that long-distance structural connectivity within the GNW plays a crucial role in conscious access and may mediate the association between impaired structural connectivity and psychosis.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Tianyi Yan, Gongshu Wang, Tiantian Liu, Guoqi Li, Changming Wang, Shintaro Funahashi, Dingjie Suo, Guangying Pei
Summary: This research uses EEG data to study different stages of schizophrenia and finds that the organization and information interactions of microstate networks play a crucial role in the disease's development, particularly in cognitive deficits.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Saba Habibi, Mohammad Yaghoubzad-Maleki, Emran Heshmati, Khosrow Khalifeh
Summary: The development of schizophrenia and some other psychiatric disorders is related to defects in the normal functioning of DISC1. DISC1 is a large-sized protein that interacts with various proteins. Ndel1, on the other hand, interacts with DISC1 and plays a role in nervous system development. Mutations on DISC1 have clinical implications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Nicholas E. Clifton, Matthew L. Bosworth, Niels Haan, Elliott Rees, Peter A. Holmans, Lawrence S. Wilkinson, Anthony R. Isles, Mark O. Collins, Jeremy Hall
Summary: This study investigates the effects of SETD1A loss-of-function mutations on gene expression and synaptic composition in mouse cortex. The results suggest that these mutations may increase the risk of schizophrenia through disruption of mitochondrial pathways and synaptic proteins. However, no genetic association with schizophrenia was found in patient genomic data.
HUMAN MOLECULAR GENETICS
(2022)
Article
Neurosciences
Moushumi Nath, Sanjeev K. Bhardwaj, Lalit K. Srivastava, Tak Pan Wong
Summary: The dysfunction of the ventral hippocampal-prefrontal cortical pathway is a core neuroimaging feature of schizophrenia. This study investigates the effects of early developmental perturbations in the ventral hippocampus on long-term functional organization in the prefrontal cortex. The findings reveal mechanisms by which the prefrontal cortex adapts to early developmental disruptions in the ventral hippocampus, providing insights into the circuit pathology of schizophrenia.
Article
Multidisciplinary Sciences
Tara C. Delorme, William Ozell-Landry, Nicolas Cermakian, Lalit K. Srivastava
Summary: Most individuals with neurodevelopmental disorders (NDDs), such as schizophrenia and autism spectrum disorders, have disrupted sleep and circadian rhythms. Prenatal infection increases the risk of developing NDDs. In this study, pregnant mice were exposed to a viral mimetic to model prenatal infection. The offspring showed behavioral differences and increased microglial morphology in the dentate gyrus, which were influenced by environmental circadian disruption. These findings suggest the importance of considering the interactions between circadian disruption and prenatal infection in developing therapies for individuals with NDDs.
SCIENTIFIC REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Meenakshi Pundir, Silvana Papagerakis, Maria C. De Rosa, Nikos Chronis, Katsuo Kurabayashi, Shahad Abdulmawjood, Mark Edward P. Prince, Liubov Lobanova, Xiongbiao Chen, Petros Papagerakis
Summary: The internally driven circadian rhythm controls physiological processes in the body, and the central clock in the hypothalamus is influenced by external cues, such as light. Dysfunction in this complex network can lead to circadian disruption and health problems.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Psychiatry
Ying Zhao, Qiongge Guan, Jingyi Shi, Jiewei Sun, Qi Wang, Jianzhou Yang, Ravi Retnakaran, Jinhong Han, Xiangyang Zhang, Wei Hao, Xin Huang, Ruiling Zhang, Desheng Zhai, Shi Wu Wen
Summary: This study evaluated the impact of quetiapine treatment on the central set point of thyroid homeostasis in patients with acute phase schizophrenia. The results showed that quetiapine exposure was associated with a significant decline in thyroid indices and there was a dose-response relationship.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Valentina Mancini, Vincent Rochas, Martin Seeber, Nicolas Roehri, Tonia A. Rihs, Victor Ferat, Maude Schneider, Peter J. Uhlhaas, Stephan Eliez, Christoph M. Michel
Summary: This study investigates the abnormalities in brain oscillations in 22q11.2 deletion carriers and reveals more severe abnormalities associated with psychotic symptoms. The study also demonstrates the lack of age-related changes in deletion carriers, indicating potential developmental impairments.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Business
Fred eric Godart, Luca Pistilli
Summary: This study categorizes disruptive phenomena into four types: technological, business model, regulatory, and social movements. Through analyzing existing literature and empirical case studies, the research reveals the characteristics of different types of disruption and how they affect industry players.
JOURNAL OF BUSINESS RESEARCH
(2024)
Article
Neurosciences
P. Abad-Perez, F. J. Molina-Paya, L. Martinez-Otero, V. Borrell, R. L. Redondo, J. R. Brotons-Mas
Summary: We investigated the role of NMDAr function in pathological oscillations and behavior in schizophrenia. Our results show that NMDAr blockade disrupted the correlation between oscillations and speed of movement, crucial for internal representations of distance. Moreover, NMDAr function might explain several cognitive symptoms of schizophrenia and be crucial to hippocampal-prefrontal cortex interaction.
Article
Psychology, Clinical
Mathias K. Kammerer, Stephanie Mehl, Lea Ludwig, Tania M. Lincoln
Summary: The study found that patients with persecutory delusions had lower subjective sleep quality but higher actigraphic-measured sleep duration and efficiency. Circadian rhythm disruption was associated with more severe persecutory symptoms, and low sleep efficiency could predict next-day persecutory symptoms. Therapeutic interventions targeting the reduction of persecutory symptoms may benefit from including modules focused on improving sleep efficacy and stabilizing sleep-wake patterns.
JOURNAL OF ABNORMAL PSYCHOLOGY
(2021)