Article
Medicine, Research & Experimental
Joyce Hou, Evelyn Tolbert, Mark Birkenbach, Nisanne S. Ghonem
Summary: This study demonstrates that treprostinil has a significant hepatoprotective effect during renal ischemia-reperfusion injury, improving liver function, antioxidant levels, suppressing inflammation, and alleviating apoptotic injury, indicating its therapeutic potential in reducing hepatic injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Hucheng Ma, Haozhen Ren, Jun Wang, Xianwen Yuan, Xinyu Wu, Xiaolei Shi
Summary: Glabridin can significantly alleviate oxidative stress, inflammation, and apoptosis induced by APAP, exerting a protective effect by activating the PI3K/Akt/Nrf2/HO-1 pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Neurosciences
Xiaoya Wang, Qingbao Xu, Shali Wang
Summary: The study revealed that overexpression of miR-149-5p can protect the rat brain against I/R injury by regulating Notch2-mediated inflammation and apoptosis pathway.
NEUROMOLECULAR MEDICINE
(2022)
Article
Immunology
Naeimah S. Sulayman Aboulqassim, Sara H. Hazem, Maha H. Sharawy, Ghada M. Suddek
Summary: ROF has been found to have protective effects on hepatic and testicular injury induced by cadmium, including restoring tissue structure, reducing immune cell infiltration, restoring oxidative status, inhibiting proinflammatory signaling pathways, alleviating endoplasmic reticulum stress, mitigating apoptotic injury, restoring barrier integrity, and promoting the regenerative potential of the testes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Zhongbao Chen, Fengjiao Hu, Yalong Zhang, Long Zhang, Tianyu Wang, Chenyang Kong, Haochong Hu, Jiayu Guo, Qi Chen, Bo Yu, Yiting Liu, Jilin Zou, Jiangqiao Zhou, Tao Qiu
Summary: This study revealed that USP29 plays an important role in hepatic ischemia/reperfusion injury by regulating the TAK1-JNK/p38 signaling pathway. Knockout of USP29 exacerbated inflammatory infiltration and injury processes, while overexpression of USP29 alleviated liver injury by decreasing inflammation and inhibiting apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Qinyuan Pan, Yang Liu, Wenrui Ma, Rongsheng Kan, Hong Zhu, Dongye Li
Summary: Luteolin has cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI) by reducing myocardial infarct size and improving intracardiac hemodynamics. It exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects through different signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jian Zhang, Man-ka Zhang, Hui-min Ma, Xin-cheng Song, Yuan-ni Wu, Rui Zhang, Ling-ling He, Xiao-hui Ye, Mei-xin Gao, Xin Li
Summary: The study suggests that C6orf120 gene deficiency may increase susceptibility to carbon tetrachloride-induced acute liver injury in rats, potentially through increased inflammation and activation of the NLRP3 inflammasome and JNK signaling pathway.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Asha Jacob, Zhimin Wang, Hao Ting Yen, Ping Wang
Summary: Administering human AM/AMBP-1 significantly decreased levels of liver enzymes and lactate dehydrogenase, reduced bilirubin levels, and inhibited interleukin-6 gene expression in a rabbit model of hepatic I/R injury. The treatment also reduced apoptosis in the ischemic portion of the liver. Further research is needed to fully understand the potential of human AM/AMBP-1 as a novel therapeutic for hepatic I/R injury.
Article
Cell Biology
Yongmei Cao, Weifeng Huang, Fang Wu, Jiawei Shang, Feng Ping, Wei Wang, Yingchuan Li, Xuan Zhao, Xiaoping Zhang
Summary: ZFP36 plays a crucial role in lung injury induced by I/R, mediating inflammation-associated lung damage by interacting with the CREBBP/p53/p21/Bax pathway. The downregulation of ZFP36 increases the level of fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Biology
Bishoy El-Aarag, Alshaimaa Attia, Magdy Zahran, Ali Younes, Ehab Tousson
Summary: The phthalimide analog showed ameliorative effects on carbon tetrachloride-induced liver injury in mice by demonstrating significant antioxidant activity, inhibition of protein expressions, and improvement in markers of oxidative stress, inflammation, and apoptosis mechanisms.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Qing Yang, Zhen-zhen Zhao, Jian Xie, Yun-peng Wang, Kai Yang, Yu Guo, Jia-feng Wang, Xiao-ming Deng
Summary: The study found that the optimal dose of SEI in treating liver I/R injury was 200 mg/kg. SEI administration reduced ALT, AST, and histopathological injury in I/R liver, similar to GSH. SEI treatment decreased TNF-alpha, IL-113, and IL-6 in liver I/R mice, and inhibited phosphorylation of p65 NF-Kappa B and MAPK kinases in liver tissues. SEI also showed antioxidative, anti-inflammatory, and anti-apoptotic effects in both in vivo and in vitro experiments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Nishant Ranjan Chauhan, Soumya Kundu, Ramyasing Bal, Diya Chattopadhyay, Rinku Sahu, Subhash Mehto, Rina Yadav, Sivaram Krishna, Kautilya Kumar Jena, Sameekshya Satapathy, Anusha Pv, Krushna C. Murmu, Bharati Singh, Srinivas Patnaik, Sarita Jena, Krishnan H. Harshan, Gulam Hussain Syed, Mohammed M. Idris, Punit Prasad, Santosh Chauhan
Summary: Interferon Type I (IFN-I) response plays a crucial role in host defense against SARS-CoV-2 infection. Through mouse models, it has been found that a high level of IFN-I response can protect against lethal SARS-CoV-2 infection, while a dampened IFN-I response may lead to severe infection and immune inflammation.
Article
Cardiac & Cardiovascular Systems
Huairui Shi, Yang Gao, Zhen Dong, Ji'e Yang, Rifeng Gao, Xiao Li, Shuqi Zhang, Leilei Ma, Xiaolei Sun, Zeng Wang, Feng Zhang, Kai Hu, Aijun Sun, Junbo Ge
Summary: The study demonstrates the significant role of GSDMD-mediated cardiomyocyte pyroptosis in myocardial I/R injury, and suggests that the caspase-11/GSDMD pathway may be essential to this process. Furthermore, GSDMD inhibition significantly reduces cardiomyocyte pyroptosis and I/R-induced myocardial injury.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yan Zhou, Xiawei Ji, Jiajing Chen, Yaoyang Fu, Juewei Huang, Rui Guo, Jinhui Zhou, Jianke Cen, Qihao Zhang, Anne Chu, Yingpeng Huang, Changlong Xu, Fangyan Wang
Summary: Butyrate treatment alleviated chronic gastric mucosa lesions in mice by regulating oxidative stress and inflammatory responses, promoting gastric mucosal repair factors, and the upregulation of specific receptor GPR109A played a key role in the therapeutic effects.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Plant Sciences
Jingyi Cai, Jiasheng Wu, Su Fang, Shaoyong Liu, Tianming Wang, Yuanyuan Li, Juan Zou, Rong Shi, Zhengtao Wang, Li Yang, Yueming Ma
Summary: CBBP treatment alleviates ANIT-induced cholestasis and liver injury by reducing hepatocyte inflammation and apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Juanjuan Luo, Pei Liu, Chunjiao Lu, Wanping Bian, Dongsheng Su, Chenchen Zhu, Shaolin Xie, Yihang Pan, Ningning Li, Wei Cui, De-Sheng Pei, Xiaojun Yang
Summary: The research indicates that combined deletions of nf1, tp53, and rb1 genes in zebrafish greatly promote gliomagenesis, with these glioma models showing relevance to temozolomide treatment.
Article
Clinical Neurology
Zilong Wang, Changyu Jiang, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, Ru-Rong Ji
Summary: The study demonstrates that intrathecal opioids can induce itching by acting on MOR on spinal inhibitory interneurons, resulting in disinhibition of the spinal itch circuit. In addition, spinal ablation of GRPR(+) neurons can reduce opioid-induced itch, while intrathecal NPY administration can suppress itch response.
Article
Neurosciences
Xin Luo, Ouyang Chen, Zilong Wang, Sangsu Bang, Jasmine Ji, Sang Hoon Lee, Yul Huh, Kenta Furutani, Qianru He, Xueshu Tao, Mei-Chuan Ko, Andrey Bortsov, Christopher R. Donnelly, Yong Chen, Andrea Nackley, Temugin Berta, Ru-Rong Ji
Summary: The IL-23/IL-17A/TRPV1 axis regulates female-specific mechanical pain, with IL-23 inducing pain in females but impaired in mice lacking IL-23 or IL-23r. IL-23-induced pain is promoted by estrogen and suppressed by androgen.
Article
Medicine, General & Internal
Yachen Si, Lulu Liu, Jin Cheng, Tingting Zhao, Qi Zhou, Jianpeng Yu, Wei Chen, Jiarong Ding, Xuejun Sun, Hongtao Lu, Zhiyong Guo
Summary: The study demonstrated that hydrogen-rich water can improve crystal deposition, tubular injury, fibrosis, and ROS production in mouse kidneys induced by oxalate diet, and reduce renal injury, inflammation, and oxidative stress indexes. A total of 3,566 differential genes were screened by RNA-seq, and the PI3K/AKT, NF-kappa B, and TGF-beta pathways were identified as key targets for further investigation.
FRONTIERS IN MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Caiyou Zeng, Xuejun Sun, Bojin Qi, Yipeng Wang, Haibo Wang, Zhejun Tan, Yong Peng, Baoqiang Cong
Summary: This study demonstrates a novel strategy to enhance the strength and ductility of AA2219 Al-6.3Cu alloy arc-welded joints by introducing TiC particles and using a distinctive ultrasonic frequency double-pulsed arc. The fabricated TiCp/Al6.3Cu joint shows a fine-grained structure and a hierarchical alpha-Al grain structure embedded with dense nano-precipitation. The joint exhibits an unprecedented joint coefficient and excellent mechanical performance.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Cell Biology
Xuan Shi, Lina Zhu, Sheng Wang, Wanli Zhu, Quanfu Li, Juan Wei, Di Feng, Meiyun Liu, Yuanli Chen, Xuejun Sun, Hongtao Lu, Xin Lv
Summary: This study explored the protective effects of magnesium hydride (MgH2) on two types of ARDS models and its underlying mechanism in a lipopolysaccharide (LPS)-induced ARDS model of the A549 cell line. Results showed that MgH2 exerted anti-inflammatory, antioxidant, anti-apoptotic, and barrier-protective effects by regulating molecular signaling pathways. The in vivo study also demonstrated that MgH2-treated mice had a better survival rate and less pathological damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Xiaoya Li, Xueqi Ma, Xintong Chen, Tingfang Wang, Qing Liu, Yongfang Wang, Zhezhe Li, Juan Hofer, Fangbing Li, Liang Xiao, Xuejun Sun, Jinggang Mo
Summary: This study analyzed the molecular composition of the medusa and polyp of Aurelia coerulea and compared its toxicity with another scyphozoan jellyfish, Stomolophus meleagris. The results showed that A. coerulea medusae and polyps have similar molecular compositions, but their gene expressions are significantly different. A. coerulea medusa displayed weaker toxicity compared to S. meleagris medusa, and the variation in toxin expressions may be an important factor contributing to the difference in toxicity.
Article
Engineering, Manufacturing
Xuejun Sun, Bojin Qi, Zihao Jiang, Caiyou Zeng, Baoqiang Cong
Summary: In this study, different current modes were used to butt-weld 1460 Al-Li alloy plates. The effects of these current modes on the weld microstructure and mechanical properties were compared. The results showed that modulating pulsed current can refine the grains in the weld zone and fusion zone, and significantly increase the quantity and width of a fine strip-like equiaxed grain zone. Both P-VPTIG and DP-VPTIG processes effectively enhanced the strength and elongation of the joints.
JOURNAL OF MANUFACTURING PROCESSES
(2022)
Article
Anesthesiology
Kenta Furutani, Ouyang Chen, Aidan McGinnis, Yuqing Wang, Charles N. Serhan, Trond Vidar Hansen, Ru-Rong Ji
Summary: The article demonstrates that 3-oxa-PD1 effectively reduces both acute and chronic itch in mouse models by regulating synaptic transmission and astroglial LCN2 production. Stable SPM analogs like 3-oxa-PD1 could be useful in treating pruritus associated with different skin injuries.
Article
Economics
Jingpei Ma, Xuejun Sun
Summary: The development of green technology allows manufacturers in traditional industries to reduce carbon emissions, but the adoption of this technology varies among manufacturers. By implementing an effective green technology licensing strategy, highly efficient manufacturers can share their technology with less efficient manufacturers. The government has introduced subsidies to promote the use of green technology among manufacturers. However, the effectiveness of these subsidies, especially in the face of intense market competition, is still uncertain. This study develops a game theory model to analyze the optimal subsidy policy for the government.
MANAGERIAL AND DECISION ECONOMICS
(2023)
Editorial Material
Medicine, Research & Experimental
Xuejun Sun, Shigeo Ohta, John H. Zhang
MEDICAL GAS RESEARCH
(2023)
Article
Immunology
Chunjing Bao, Ouyang Chen, Huaxin Sheng, Jeffrey Zhang, Yikai Luo, Byron W. Hayes, Han Liang, Wolfgang Liedtke, Ru-Rong Ji, Soman N. Abraham
Summary: IgE-mediated anaphylaxis is a life-threatening systemic reaction triggered by allergens, resulting in the release of mediators from mast cells. The drop in body temperature associated with anaphylaxis in mice also involves the activation of the body's thermoregulatory neural circuit. This circuit is activated by chymase from mast cells stimulating TRPV1+ sensory neurons, leading to hypothermia.
SCIENCE IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ouyang Chen, Qianru He, Qingjian Han, Kenta Furutani, Yun Gu, Madelynne Olexa, Ru-Rong Ji
Summary: Our understanding of neuropathic itch is limited due to a lack of relevant animal models. In this study, we established a mouse model of chronic itch by inoculating cutaneous T cell lymphoma (CTCL) in mice. The model exhibited lymphoma growth, immune cell accumulation, and persistent pruritus. We observed time-dependent changes in nerve innervations and identified different mechanisms underlying acute, chronic, and neuropathic itch.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Engineering, Biomedical
Jing Ma, Suhe Dong, Hongtao Lu, Zhongmin Chen, Huijie Yu, Xuejun Sun, Renjun Peng, Wei Li, Sinian Wang, Qisheng Jiang, Fengsheng Li, Li Ma
Summary: This study revealed the protective effect of MgH2, a hydrogen storage nanomaterial, on radiation-induced male fertility impairment. MgH2 improved testicular structure, sperm quality, genetic effect, spermatogenesis, and hormone secretion. It also eliminated free radicals, suppressed ROS production, alleviated oxidative stress, and inhibited apoptosis and inflammation induced by radiation.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Organic
Jannicke Irina Nesman, Ouyang Chen, Xin Luo, Ru-Rong Ji, Charles N. Serhan, Trond Vidar Hansen
Summary: This study focuses on a new analog of protectin D1, 3-oxa-PD1(n-3 DPA), which demonstrated significant alleviation of streptozotocin-induced diabetic neuropathic pain in mouse models as well as itching symptoms in a chronic itch model of cutaneous T-cell lymphoma. These findings highlight the potential of developing new immunoresolvents based on the structure-functions of protectins and their synthetic analogs.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)