Article
History & Philosophy Of Science
Peter Langland-Hassan
Summary: This paper discusses criticisms of the causal theory of memory and proposes a revised causal theory through considering the phenomenon of forgetting through repetition. The revised theory suggests that individual memory traces are shaped by multiple past experiences.
Article
Ethics
Mads Dahl Gjefsen, Knut Jorgen Vie
Summary: Researchers' communication activities are influenced by motivations, abilities, specific topics, and artifacts of research. Different communication objects may have various affordances, both enabling and constraining features, indicating the need for artifact-specific approaches to researchers' attitudes towards communication and the institutionalization of Responsible Research and Innovation (RRI).
JOURNAL OF RESPONSIBLE INNOVATION
(2021)
Editorial Material
Computer Science, Software Engineering
Niels Christian Nilsson, Andre Zenner, Adalberto L. Simeone
Summary: This article introduces a taxonomy for organizing techniques using haptic proxies for delivering a sense of touch in virtual reality. The success of these techniques depends on the similarity and colocation of physical props with their virtual counterparts, as well as the deployment time, reality manipulation, and purpose of the techniques. Key advantages and limitations of the different categories of techniques are also discussed.
IEEE COMPUTER GRAPHICS AND APPLICATIONS
(2021)
Editorial Material
Multidisciplinary Sciences
Marissa Mock, Suzanne Edavettal, Christopher Langmead, Alan Russell
Summary: Artificial intelligence tools can facilitate data sharing on drug candidates while ensuring the security of sensitive information, enabling the utilization of machine learning and cutting-edge lab techniques for the benefit of society.
Review
Pharmacology & Pharmacy
Hossein Omidian, Jafar Razmara, Sepideh Parvizpour, Hamed Tabrizchi, Yosef Masoudi-Sobhanzadeh, Yadollah Omidi
Summary: The life cycle of a drug starts from its discovery and ends when it is disposed. Various entities such as drug discovery companies, manufacturers, regulatory agencies, suppliers, pharmacies, patients, and healthcare providers are involved in this process. Transparency, traceability, automation, and data security play crucial roles in ensuring effective and safe transactions among all parties. However, challenges like scalability, energy consumption, regulations, standards, and complexity hinder the adoption of new technology that can fulfill these requirements. This article highlights how blockchain technology can track, accelerate, and enhance the efficiency of complex operations like pharmaceutical development.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Graziano, Angela Stefanachi, Marialessandra Contino, Ruben Prieto-Diaz, Alessia Ligresti, Poulami Kumar, Antonio Scilimati, Eddy Sotelo, Francesco Leonetti
Summary: Multicomponent reactions (MCRs) are widely used in synthetic organic chemistry for drug discovery and development due to their flexibility in forming complex products with high efficiency. They are considered as an exploratory and evolutionary tool in medicinal chemistry, enabling sustainable and rapid synthesis of biologically active molecules. This review provides an overview of the approaches and applications of MCRs in the development of new anticancer drugs, showcasing their extensive use in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
K. L. T. Dilrukshi Jayawardene, Enzo A. Palombo, Peter R. Boag
Summary: Parasitic nematodes infect a wide range of organisms and have significant impact on human health and agriculture. The main method of controlling these parasites is through anthelmintic drugs, but there is limited selection in the market and resistance is a major issue. Therefore, the development of new anthelmintics is crucial for sustainable parasitic control.
Article
Biochemistry & Molecular Biology
William A. Eaton
Summary: This article discusses the author's transition from spectroscopy to drug discovery for treating sickle cell disease. The author's lab has developed a high throughput assay and discovered multiple potential oral drugs for sickle cell disease in a drug repurposing library.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Medicinal
Hongming Chen
Summary: While AI applications in drug discovery are increasing, examples with full DMTA outcomes are still rare. A recent study demonstrated the potential of a generative model in the drug discovery process, showing that ideas generated by AI could be validated through wet-lab works.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Yihui Song, Xiaoke Yang, Bin Yu
Summary: Drug repurposing is an attractive strategy for finding new indications for existing drugs. Three approved antidepressants have shown potential in clinical trials for cancer treatment. By conducting further medicinal chemistry research, several TCP-based inhibitors of the histone lysine specific demethylase 1 enzyme have been discovered, showing promise for cancer treatment. Repurposing antidepressants could be a promising strategy for cancer treatment.
DRUG DISCOVERY TODAY
(2022)
Review
Chemistry, Medicinal
Bhawna Chopra, Ashwani Kumar Dhingra
Summary: Natural products have been used in folklore for centuries for treating various ailments, with plant-derived products recognized as a source of therapeutic agents and structural diversity. After small modifications, natural molecules can offer better pharmacological potential as new molecular entities.
PHYTOTHERAPY RESEARCH
(2021)
Review
Chemistry, Medicinal
Julie Ross, Caitlin E. Miron, Jessica Plescia, Patricia Laplante, Kevin McBride, Nicolas Moitessier, Tarik Moroy
Summary: The MYC oncogene is a high priority target for clinical intervention in cancer patients, with direct small molecule inhibition traditionally facing challenges due to its intrinsically disordered nature. However, recent strategies for indirectly targeting MYC, such as MYC guanine quadruplex stabilization and disruption of MYC:MAX heterodimer, have emerged with the advancement of protein structural information and computational tools in medicinal chemistry.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Yojana Gadiya, Andrea Zaliani, Philip Gribbon, Martin Hofmann-Apitius
Summary: The study develops a patent enrichment tool called PEMT, which extracts relevant patent information linked to chemical structures and gene names. It supports drug discovery and research by establishing a patent landscape around genes of interest. The tool is open-source and its source code and software package are available through the provided link.
Article
Biology
Jonne Rietdijk, Marianna Tampere, Aleksandra Pettke, Polina Georgiev, Maris Lapins, Ulrika Warpman-Berglund, Ola Spjuth, Marjo-Riitta Puumalainen, Jordi Carreras-Puigvert
Summary: The emergence and global spread of the COVID-19 pandemic has underscored the need for efficient methods to identify new or repurposed therapeutic drugs. A new method combining Cell Painting and anti-virus antibody stain has been developed for unbiased morphological profiling of virus infection on host cells, demonstrating its potential for antiviral drug screening and discovery.
Article
Chemistry, Medicinal
Yi-Fan Chen, Chien-Huang Wu, Li-Hsien Chen, Hao-Wei Lee, Jinq-Chyi Lee, Teng-Kuang Yeh, Jang-Yang Chang, Ming-Chen Chou, Hui-Ling Wu, Yen-Po Lai, Jen-Shin Song, Kai-Chia Yeh, Chiung-Tong Chen, Chia-Jui Lee, Kak-Shan Shia, Meng-Ru Shen
Summary: Chemotherapy-induced neurotoxicity is a common adverse effect of cancer treatment, and there is currently no effective medication for prevention or treatment. However, the discovery of CN016 as a neuroprotective agent shows promise, as it can inhibit inflammatory responses and alleviate nerve damage caused by chemotherapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Olivia Weeks, Gabriel D. Bosse, Isaac M. Oderberg, Sebastian Akle, Yariv Houvras, Paul J. Wrighton, Kyle LaBella, Isabelle Iversen, Sahar Tavakoli, Isaac Adatto, Arkadi Schwartz, Daan Kloosterman, Allison Tsomides, Michael E. Charness, Randall T. Peterson, Matthew L. Steinhauser, Pouneh K. Fazeli, Wolfram Goessling
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Plant Sciences
Joshua P. Torres, Zhenjian Lin, David S. Fenton, Lee U. Leavitt, Changshan Niu, Pui-Ying Lam, Jose Miguel Robes, Randall T. Peterson, Gisela P. Concepcion, Margo G. Haygood, Baldomero M. Olivera, Eric W. Schmidt
JOURNAL OF NATURAL PRODUCTS
(2020)
Review
Biochemistry & Molecular Biology
T. Zhang, R. T. Peterson
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Pui-Ying Lam, Aditya R. Thawani, Enrique Balderas, Andrew J. P. White, Dipayan Chaudhuri, Matthew J. Fuchter, Randall T. Peterson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Plant Sciences
Guangwei Wu, Bryn T. M. Dentinger, Jason R. Nielson, Randall T. Peterson, Jaclyn M. Winter
Summary: The fermentation of Acremonium tubakii W. Gams isolated from soil samples collected from the University of Utah led to the discovery of six new linear pentadecapeptides, named emerimicins V-X. Detailed bioinformatic investigations and experimental techniques were used to elucidate the amino acid composition and configuration of these peptides, revealing significant activity in two of them.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Gabriel D. Bosse, Cristoval Urcino, Maren Watkins, Paula Florez Salcedo, Sabrina Kozel, Kevin Chase, April Cabang, Samuel S. Espino, Helena Safavi-Hemami, Shrinivasan Raghuraman, Baldomero M. Olivera, Randall T. Peterson, Joanna Gajewiak
Summary: Natural products like conotoxins have great potential in biomedical research and treating human diseases. Developing a rapid screening method using zebrafish larvae, researchers identified a bioactive conotoxin, CNF-Ep1, which not only affected the locomotor behavior of the larvae but also showed activity in mouse assay systems. This novel screening platform can accelerate the discovery of bioactive marine natural products with potential implications for understanding neuronal circuitry.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Noemi D. Paguigan, Jortan O. Tun, Lee S. Leavitt, Zhenjian Lin, Kevin Chase, Cheryl Dowell, Cassandra E. Deering-Rice, Albebson L. Lim, Manju Karthikeyan, Ronald W. Hughen, Jie Zhang, Randall T. Peterson, Christopher A. Reilly, Alan R. Light, Shrinivasan Raghuraman, J. Michael McIntosh, Baldomero M. Olivera, Eric W. Schmidt
Summary: Molleamines A-E were identified as major neuroactive components in sea slugs and their prey tunicates, with synthetic 3 showing potential as a lead compound for developing neuroactive compounds with unique biological properties.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Saba Parvez, Chelsea Herdman, Manu Beerens, Korak Chakraborti, Zachary P. Harmer, Jing-Ruey J. Yeh, Calum A. MacRae, H. Joseph Yost, Randall T. Peterson
Summary: MIC-Drop is a platform combining droplet microfluidics, single-needle en masse CRISPR ribonucleoprotein injections, and DNA barcoding, enabling large-scale functional genetic screens in zebrafish to efficiently identify genes responsible for morphological or behavioral phenotypes. It has the potential to scale to thousands of genes, facilitating genome-scale reverse genetic screens in model organisms.
Article
Developmental Biology
Yijie Geng, Randall T. Peterson
Summary: This study developed a method using a computer numerical controlled manufactured mold to create larva-shaped slots in agarose gel for easier mounting of zebrafish larvae in a vertical position. Compared to the current manual holding method, this new technique is not only less time-consuming and labor-intensive, but also beginner-friendly.
Article
Biochemistry & Molecular Biology
Stephanie A. Carmack, Janaina C. M. Vendruscolo, M. Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D. Bosse, Daniele Mercatelli, Federico M. Giorgi, Yu Fu, Anthony J. Hinrich, Francine M. Jodelka, Karen Ling, Robert O. Messing, Randall T. Peterson, Frank Rigo, Scott Edwards, Pietro P. Sanna, Marisela Morales, Michelle L. Hastings, George F. Koob, Leandro F. Vendruscolo
Summary: This study explores the mechanistic role of extrahypothalamic stress systems in driving opioid addiction and finds that glucocorticoid receptor antagonism with mifepristone reduces opioid addiction-like behaviors and decreases the firing of corticotropin-releasing factor neurons in the rat amygdala.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Jason R. Nielson, Anjali K. Nath, Kim P. Doane, Xu Shi, Jangwoen Lee, Emily G. Tippetts, Kusumika Saha, Jordan Morningstar, Kevin G. Hicks, Adriano Chan, Yanbin Zhao, Amy Kelly, Tara B. Hendry-Hofer, Alyssa Witeof, Patrick Y. Sips, Sari Mahon, Vikhyat S. Bebarta, Vincent Jo Davisson, Gerry R. Boss, Jared Rutter, Calum A. MacRae, Matthew Brenner, Robert E. Gerszten, Randall T. Peterson
Summary: Cyanide acts as a metabolic poison by inhibiting cytochrome c oxidase and other metabolic enzymes, causing metabolic perturbations. Glyoxylate has been identified as a potential cyanide countermeasure that can effectively and rapidly mitigate cyanide toxicity in animal models.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Tejia Zhang, Ivy Alonzo, Chris Stubben, Yijie Geng, Chelsea Herdman, Nancy Chandler, Kim P. Doane, Brock R. Pluimer, Sunia A. Trauger, Randall T. Peterson
Summary: Sphingolipidoses, a type of lysosomal storage disease, cause early mortality and limited treatment options due to neurological involvement. Demyelination pathways were investigated in a zebrafish model with combined saposin deficiency, and severe myelin loss was observed. Dysregulated mTORC1 signaling and neuroinflammation were found, and the modulation of acid sphingomyelinase activity showed potential as a treatment approach.
DISEASE MODELS & MECHANISMS
(2023)
Article
Biochemical Research Methods
Yijie Geng, Christopher Yates, Randall T. Peterson
Summary: Researchers developed the ZeChat assay, a scalable social behavioral evaluation method for zebrafish using unsupervised deep learning. Screening a compound library, they found that different classes of chemicals induce distinct patterns of social behavior. Dopamine D3 agonists were found to have a social stimulative effect and rescued social deficits in a zebrafish autism model. The ZeChat platform offers a promising approach for studying the pharmacology of social behavior and discovering new social-modulatory compounds.
CELL REPORTS METHODS
(2023)
Review
Clinical Neurology
Aleksandr Shcheglovitov, Randall T. Peterson
Summary: Recent advances in molecular and cellular engineering have improved the pace and precision of investigating human disorders. This progress is expected to lead to the development of innovative drug-screening platforms and new patient-specific therapeutics.
Article
Medicine, Research & Experimental
Gabriel D. Bosse, Roberto Cadeddu, Gabriele Floris, Ryan D. Farero, Eva Vigato, Suhjung J. Lee, Tejia Zhang, Nilesh W. Gaikwad, Kristen A. Keefe, Paul E. M. Phillips, Marco Bortolato, Randall T. Peterson
Summary: Research has shown that finasteride reduces self-administration of multiple opioids and physical signs of opioid withdrawal in zebrafish and rat models. Steroidogenic pathways are highlighted as important therapeutic targets for opioid use disorder, with finasteride potentially offering a new treatment option.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
