期刊
NATURE
卷 455, 期 7217, 页码 1248-1250出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature07282
关键词
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资金
- Medical Research Council
- MRC [G0401313] Funding Source: UKRI
- Medical Research Council [G0401313] Funding Source: researchfish
It has long been known that the 59 to 39 polarity of DNA synthesis results in both a leading and lagging strand at all replication forks(1). Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escherichia coli is not random but is driven in a manner that results in the leading and lagging strands being addressed to particular cellular destinations. These destinations are consistent with the known patterns of chromosome segregation(2,3). Our work demonstrates a new level of organization relating to the replication and segregation of the E. coli chromosome.
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