期刊
NATURAL PRODUCT RESEARCH
卷 28, 期 11, 页码 776-781出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.880911
关键词
Aspergillus; co-fermentation; marine-derived fungi; anti-proliferative
资金
- Ministry of Economics and Technology, Germany
- NSFC [30910103914]
Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketide derivatives (4-6). The chemical structure and relative and absolute configurations of psychrophilin E (1) were unambiguously established based on HRMS, 1D, 2D NMR and chiral-phase HPLC analysis of its hydrolysate. All the isolated compounds were assessed for their anti-proliferative activity against four different human cancer cell lines and some of them revealed selective activities.
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