Review
Chemistry, Organic
Bo-Ya Hao, Ya-Ping Han, Yuecheng Zhang, Yong-Min Liang
Summary: Fluorinated organic compounds, especially those containing the OCF3 group, are of great importance in various fields. In recent years, the synthesis of trifluoromethoxylated compounds has attracted much attention, and different strategies have been developed for their efficient and practical synthesis. These strategies involve de novo formation of the OCF3 group, trifluoromethylation of alcohols or phenols, direct installation of the OCF3 group onto complex molecules, visible-light-induced trifluoromethoxylation, transition metal-catalyzed trifluoromethoxylation, and rearrangement reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Weiqiang Yang, Xinghua Li, Liling Fei, Weizhen Liu, Xiuling Liu, Haiyang Xu, Yichun Liu
Summary: This review systematically summarizes the green synthesis approaches for various classes of QDs, including carbon-based dots, binary QDs, and multi-component QDs, with a focus on bottom-up methods utilizing biomass materials, green solvents, and biological organism design.
Review
Chemistry, Organic
Rodrigo Abonia, Oscar Montoya
Summary: This review examines the progress in literature on the synthesis of 1,2,2-triarylethanone derivatives from 2000 to 2020, exploring various synthetic approaches such as metal-free, metal-mediated, C-H bond activation, alpha-monoarylation, alpha,alpha-diarylation, umpolung processes, N heterocyclic carbene (NHC), and deoxygenation. Mechanistic proposals and reported data on carbon-carbon bond formation through ketone based alpha-arylation processes are also briefly discussed and organized for comparison in concise Tables/Schemes.
CURRENT ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Raul R. Rodriguez-Berrios, Stephen R. Isbel, Alejandro Bugarin
Summary: Polypropionate units, found in many natural products, have antimicrobial and therapeutic potential. This review includes all epoxide-based methodologies developed by research groups such as Kishi, Katsuki, Marashall, Miyashita, Prieto, Sarabia, Jung, McDonald, etc. for the synthesis of polypropionates. The review also includes the isolation and biological activities of synthetized polypropionates and related natural products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Dmitry Y. Mladentsev, Ekaterina N. Kuznetsova, Maria N. Skvortsova, Ratmir R. Dashkin
Summary: This article reviews the preparation of Rivaroxaban and discusses its applicability in large-scale production. The common intermediates are discussed in detail and relevant comparisons are made. The article provides an overview of the current state of research and suggests possible directions for further development.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Chemistry, Multidisciplinary
Manoj Gayke, Hanuman Narode, Gyanchander Eppa, Rajesh S. Bhosale, Jhillu Singh Yadav
Summary: Epilepsy is a chronic neurological disorder affecting individuals of all age groups, with the main treatment option being the antiepileptic drug brivaracetam. This drug has shown great efficacy in limiting the progression of epilepsy and has drawn significant attention from researchers for further synthesis advancements.
Review
Chemistry, Applied
Vikas Rathod, Pankaj Saini, Ramandeep Kaur, Srinivasa Marimganti, Kamlesh J. Ranbhan
Summary: Vildagliptin is an oral antidiabetic agent used to treat type 2 diabetes. It is preferred due to its mechanism of action and superior gastrointestinal tolerability. However, there is a lack of review articles summarizing all synthetic processes of vildagliptin.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Review
Chemistry, Organic
Krishnaji Tadiparthi, Swathy Venkatesh
Summary: This review outlines the total synthesis of natural products based on the butenolide core unit. It highlights the synthetic methods involved in the preparation of butenolide-containing molecules and aims to increase the profile of such scaffolds to the synthetic community.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Review
Chemistry, Applied
Siddhanath D. Bhosle, Shivanand Itage, Balraju Gangapuram, Gyanchander Eppa, Rajesh S. Bhosale, Jhillu Singh Yadav
Summary: Schizophrenia, a chronic and severe mental disorder, affects 20 million people worldwide. The causes of schizophrenia are not yet fully understood, but it is believed that interactions between genes and environmental factors play a role. Antipsychotic drugs, including cariprazine, are commonly used to control schizophrenia. This review provides a brief background on the synthetic approaches to cariprazine.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Review
Chemistry, Applied
Siddhanath D. Bhosle, Shivanand V. Itage, Krishna A. Jadhav, Rajesh S. Bhosale, Jhillu Singh Yadav
Summary: Schizophrenia is a persistent and severe mental illness that affects 20 million people globally. Genetic and environmental interactions are hypothesized to be among the causes of Schizophrenia. Antipsychotic medications, including Clozapine, are commonly used to treat Schizophrenia, especially in cases where other medications have been ineffective or intolerable due to side effects. This review provides a brief overview of recent developments in the synthesis of the Clozapine drug molecule.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Review
Chemistry, Multidisciplinary
Vidya Jyothi Alli, Pawan Yadav, Vavilapalli Suresh, Surender Singh Jadav
Summary: WEE1 is a critical checkpoint kinase in mitotic events, playing a crucial role in cell maturation and DNA repair. In cancer cells, elevated levels of WEE1 kinase are often associated with progression and survival. Therefore, WEE1 kinase has emerged as a promising target for anticancer therapy. Various classes of WEE1 inhibitors have been designed using rational or structure-based techniques, and the discovery of AZD1775 has further strengthened the potential of WEE1 as an anticancer target.
Review
Chemistry, Multidisciplinary
Rabia Akhtar, Ameer Fawad Zahoor, Muhammad Irfan, Tanveer Hussain Bokhari, Atta ul Haq
Summary: The Ullmann reaction is a widely used organic synthesis for the construction of carbon-heteroatom bonds. Recent developments in green methodologies have overcome the harsh reaction conditions of the traditional Ullmann coupling. These advancements have opened up new possibilities for the synthesis of various heterocycles, drug-like molecules, and natural products.
Review
Biochemistry & Molecular Biology
Keke Li, Kirk R. Gustafson
Summary: The last seven years have seen an expansion in research efforts focused on sesterterpenoids, resulting in the discovery of numerous structurally novel and biologically active compounds. These newly reported sesterterpenoids offer diverse structures and bioactivities with potential importance in both biomedical and ecological fields. Additionally, there has been rapid growth in knowledge related to sesterterpene biosynthesis, creating new opportunities for future discovery and research.
NATURAL PRODUCT REPORTS
(2021)
Article
Plant Sciences
Jennifer A. N. Brophy
Summary: Recent advances in understanding plant development and gene expression control may lead to a new strategy for engineering plant form and function, allowing for the production of novel agricultural products designed to tolerate extreme stresses, increase yield, reduce waste, and improve manufacturing practices.
Review
Chemistry, Multidisciplinary
Mandeep, Hao Liu, Pratyoosh Shukla
Summary: Microbial endoglucanases from the beta-1-4 glycosyl hydrolase family are crucial enzymes in industries like pulp and paper, converting lignocellulosic substrates to soluble sugars and aiding in biodegradation. Biocomputational tools can help understand their catalytic activity and chemical behavior, potentially enhancing productivity and reducing costs. This review highlights interesting aspects of enzyme design, utilizing computational techniques for quality improvement, synthetic biology for faster enzyme development, and diverse protein engineering tools for enzyme modification.
