Article
Environmental Sciences
Min Zhou, Xiaotong Guan, Ting Deng, Ruiwen Hu, Lu Qian, Xueqin Yang, Bo Wu, Juan Li, Qiang He, Longfei Shu, Qingyun Yan, Zhili He
Summary: This study found that the phylogenetic diversity of bacterial communities is related to their denitrification rates and temporal stability. By experimentally evolving synthetic denitrifying communities with different phylogenetic distances, it was found that communities with higher phylogenetic diversity exhibited higher function and stability. This has important implications for using synthetic communities to address environmental issues and mitigate greenhouse gas emissions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Geochemistry & Geophysics
Michael K. Newey, Joshua M. Kantor, Gerald R. Benitz
Summary: This work focuses on improving SAR autofocus methods for moving targets, incorporating higher motion order terms to improve image quality and reduce blurring in target signatures.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Biochemistry & Molecular Biology
Hanqiao Xu, Takashi Kurohara, Nobumichi Ohoka, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu
Summary: In this study, a solid-phase synthesis method is developed for diverse PROTAC design, which includes investigating a wider range of E3 ligands and linker structures. The study expanded the E3 ligand range to include VHL and IAP ligands, and compared the suitability of PEG and alkyl linker for PROTAC synthesis. The solid-phase synthesis methods enabled rapid synthesis of multiple PROTACs for BRD4 targeting.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Kefei Liao, Jifa Shen, Shan Ouyang, Qiaoying Yu
Summary: This study proposes a deblurring target imaging method for frequency diversity arrays (FDA). By establishing a mathematical model of image domain blur and introducing deconvolution and low-error imaging methods, high-quality imaging without blur is achieved.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Samuzal Bhuyan, Dharmendra Das, Amit Chakraborty, Susanta Mandal, Kumaraswamy Dhanabal, Biswajit Gopal Roy
Summary: A carbohydrate-based diversity oriented synthetic approach was used to access structurally diverse and stereochemically complex chiral polyheterocyclic molecules. The study demonstrated the successful utilization of inexpensive D-Glucose as a chiral pool to access complex chiral structures using achiral reagents and DKHDA reaction. The newly generated polyheterocycles showed good three-dimensional scaffold diversity and drug-likeness according to chemoinformatic analysis with 40 branded drugs.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Haoyu Jing, Jie Rong, Masahiko Taniguchi, Jonathan S. Lindsey
Summary: Tetrapyrrole macrocycles play a central role in photosynthesis, and researchers have constructed arrays of these macrocycles to explore their photophysical properties and potential applications. Linking the macrocycles with phenylene units has been a common strategy in array chemistry, enabling rapid electron and energy transfer. The majority of studies have focused on porphyrins, with limited investigations on chlorins and bacteriochlorins. In addition to artificial photosynthesis, arrays chemistry also holds potential for catalytic applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Max J. Caplin, Daniel J. Foley
Summary: Fragment-based drug discovery is a crucial technology for delivering clinical candidates, but the development of sp(3)-rich fragments remains challenging. Recent advances in C(sp(3))-H functionalization offer valuable approaches to advancing fragment hits by 'growing' functionalized rings and chains from unconventional, carbon-centered vectors.
Article
Biology
Weiqi Xia, Lingyan Zheng, Jiebin Fang, Fengcheng Li, Ying Zhou, Zhenyu Zeng, Bing Zhang, Zhaorong Li, Honglin Li, Feng Zhu
Summary: This study presents a novel protein function annotation strategy, PFmulDL, which integrates multiple deep learning methods to address the limitations of existing methods in annotating proteins in "rare classes". The new model is capable of annotating a larger number of protein families and significantly improving prediction performance.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hengyou Zhang, He Jiang, Zhenbin Hu, Qijian Song, Yong-Qiang Charles An
Summary: This study consolidated the raw resequencing data of 1465 soybean genomes from public databases and newly sequenced 91 highly diverse wild soybean genomes, providing a collection of 1556 sequenced genomes. Analysis revealed 32 million single nucleotide polymorphisms (SNPs), indicating high genomic diversity. Paired accessions were identified to facilitate soybean germplasm exchange between countries, and the utility of these SNPs in post-genomics research was demonstrated.
Article
Microbiology
Taylor R. Sehein, Rebecca J. Gast, Maria Pachiadaki, Laure Guillou, Virginia P. Edgcomb
Summary: Protists play essential roles in marine food webs and biogeochemical cycles. However, there is limited data on the specific ecological niches of some of the most abundant taxa. This study investigated the prevalence of Syndiniales, a group often found in picoplankton samples, and the impacts of syndinian parasitism in a productive coastal pond. The findings suggest that seasonal shifts in protist populations, including parasitic Syndiniales, were influenced by primary productivity and temperature-driven stratification. The study highlights the propagation of syndinian parasites through mixed protist assemblages and provides insights into host/parasite interactions in marine environments.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Hojun You, Chongam Kim
Summary: Sophisticated solution algorithms and complex data structures are key barriers that hinder high-order methods from widespread adoption in industry and academia. The CsTC approach optimizes high-order methods by converting tensor operations into an optimization problem, resulting in significantly improved performance compared to non-optimized methods. This target-oriented and architecture-based optimization is fully reflective of the mesh, solution parameters, and computing architecture used.
COMPUTER PHYSICS COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Yu-Zhu Yang, Xiang-Na Chang, Xuan-Sheng Xie, Mengzhou Wang, Jian-Wu Xie
Summary: A facile domino reaction using o-isothiocyanato-(E)-cinnamaldehydes as precursors was developed to synthesize six classes of 2,4-dihydro-1H-benzo[d][1,3]thiazine derivatives with different functional groups. This study is significant for diversity-oriented synthesis method.
TETRAHEDRON LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Tingting Gu, Zhen Zhang, Shengyu Zhang, Weihua Zhu, Xu Liang
Summary: This review introduces the synthesis, properties and applications of Co(III)corroles. Different synthesis methods are discussed, and the spectroscopic and electrochemical properties of Co(III)corroles are described. The paper focuses on the application of Co(III)corroles, including energy development, degradation of organochlorides, and oxidation of alkanes.
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Adrielle P. Maximiano, Giovana S. Ramos, Marcelo V. Marques, Marcus M. Sa
Summary: A two-step method for preparing cyclopropane-carboxaldehyde-1,1-diester from gamma, delta-epoxyester is described, showing high synthetic versatility and good yields. The method can be used to efficiently synthesize various cyclopropylidene-gamma-lactams and delta-lactams in one pot.
SYNTHESIS-STUTTGART
(2021)
Article
Engineering, Electrical & Electronic
Yixiang Hu, Xueyang Li, Deng Mao, Md Samiul Alam, Essam Berikaa, Jinsong Zhang, Santiago Bernal, Alireza Samani, Mohammad E. Mousa-Pasandi, Maurice O'Sullivan, David V. Plant
Summary: This paper presents a silicon photonic phase-diverse receiver based on an asymmetric self-coherent detection (ASCD) scheme with Mach-Zehnder interferometers (MZI). The receiver has a hardware-efficient architecture and can recover complex double-sideband signals using only 2 single-ended photodiodes and 2 analog-to-digital converters. Experimental results demonstrate the successful transmission of high-speed signals, such as 60 Gbaud single-polarization 16-QAM signal and 80 Gbaud single-polarization 16-QAM DSB signal, using the SiP MZI-ASCD receiver over 40 km of single-mode fiber (SMF).
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Chemistry, Organic
Bowen Shen, Mingchun Gao, Francisco Franco, Rohan Kapre, Junhan Zhou, Xinzhe Li, Joel Garcia, Jared T. Shaw, Angelique Y. Louie
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Jared T. Shaw
Review
Chemistry, Multidisciplinary
Benjamin D. Bergstrom, Leslie A. Nickerson, Jared T. Shaw, Lucas W. Souza
Summary: Donor/donor and donor carbenes, although relatively new in carbene chemistry, have shown exquisite chemo- and stereo-selectivity in various insertion reactions. Recent studies have demonstrated high levels of diastereo- and enantioselectivity with different transition metal catalysts. Methods involving diazo-based carbene precursors and diazo-free metal carbenes have both been successful, providing context for future developments in this emerging field.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jake R. Jagannathan, James C. Fettinger, Jared T. Shaw, Annaliese K. Franz
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Mingchun Gao, Bowen Shen, Junhan Zhou, Rohan Kapre, Angelique Y. Louie, Jared T. Shaw
Article
Chemistry, Multidisciplinary
Kimberly M. Trevino, Brandon K. Tautges, Rohan Kapre, Francisco C. Franco, Victor W. Or, Edward Balmond, Jared T. Shaw, Joel Garcia, Angelique Y. Louie
Summary: This study demonstrated colorimetric copper sensing at low micromolar levels using dimethylamine-functionalized spiropyran (SP1). The SP1-Cu2+ complex formation led to a color change that could be observed by the naked eye as low as 6 μM, with a detection limit of 0.11 μM. SP1 showed high selectivity for Cu2+ ions and could be used for field testing of trace Cu2+ ions.
Article
Chemistry, Organic
Sara Y. Howard, Michael J. Di Maso, Kristin Shimabukuro, Noah P. Burlow, Darlene Q. Tan, James C. Fettinger, Thomas C. Malig, Jason E. Hein, Jared T. Shaw
Summary: The mechanisms for the three- and four-component variants of the Castagnoli-Cushman reaction have been investigated, revealing a novel mechanism involving the reversible formation of free amine and cyclic anhydride from amide-acids derived from maleic anhydride. Further experiments support a similar mechanism for the 3CR, leading to the development of new conditions for the formation of dihydroisoquinolones with high yields and excellent diastereoselectivity. This culmination of more than a decade of mechanistic speculation enables the design of new multicomponent reactions exploiting this novel mechanism.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Anna Lo, David A. Gutierrez, Garrett Toth-Williams, James C. Fettinger, Jared T. Shaw
Summary: Lewis acid mediated allylations of beta-alkoxy N-tosyl imines using allyltrimethylsilane led to the formation of anti-selective 3-alkoxy homoallylic N-tosyl amines. Two methods of Cu(OTf)(2)-mediated allylations were reported, showing that diastereoselectivity can be achieved through the 1,3 acyclic stereocontrol of beta-chiral aldimines. The observed selectivity trends and computational evidence suggest that selectivity arises through the formation of a six-membered ring chelate.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sarah N. Dishman, Croix J. Laconsay, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw
Summary: Intramolecular C-H insertions with donor/donor dirhodium carbenes provide a concise and highly stereoselective method to set two contiguous stereocenters in a single step. The study demonstrates that donor/donor carbenes undergo uniquely stereoselective reactions that originate from a stepwise reaction mechanism, in contrast to the analogous concerted reactions of carbenes with one or more electron-withdrawing groups attached.
Article
Chemistry, Multidisciplinary
Benjamin D. Bergstrom, Amy T. Merrill, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw
Summary: This article reports the first synthesis methods of Panowamycins and their epimers, and reveals the previous structural misassignment of panowamycin A and veramycin F. The researchers achieved these synthesis methods through dirhodium-catalyzed C-H insertion reactions and Wacker oxidation, avoiding the use of protecting groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Benjamin D. Bergstrom, Garrett Toth-Williams, Anna Lo, Jeffrey W. Toman, James. C. Fettinger, Jared T. Shaw
Summary: Polysubstituted allenes are valuable synthetic intermediates that offer structural complexity, modularity, and chirality for further transformations. In this study, a novel method for synthesizing tetrasubstituted allenes with geminal acyl/alkoxy substitution is reported. These unique push-pull allenes demonstrate bench-stability and interesting reactivity in various applications.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Oncology
Christopher A. Lucchesi, Jin Zhang, Mingchun Gao, Jared Shaw, Xinbin Chen
Summary: EIF4E is a cap-binding protein that is important for cap-dependent translation. Overexpression of EIF4E promotes cancer development by preferentially translating oncogenic mRNAs. The development of the disruptor 4EGI-1 inhibits oncoprotein expression for cancer therapy. RBM38 interacts with EIF4E on TP53 mRNA, prevents EIF4E from binding to TP53 mRNA cap, and inhibits TP53 expression. The derived peptide Pep8 disrupts the EIF4E-RBM38 complex, leading to increased TP53 expression and decreased tumor cell growth. Compound 094 interacts with EIF4E, dissociates RBM38 from EIF4E, and enhances TP53 translation in an RBM38- and EIF4E-dependent manner. Compound 094 suppresses tumor spheroid growth and cooperates with doxorubicin and 4EGI-1 to suppress tumor cell growth.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mingchun Gao, Jose M. Ruiz, Emily Jimenez, Anna Lo, Croix J. Laconsay, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw
Summary: Substrates designed for 1,4-C-H insertion to produce benzocyclobutenes underwent a unique elimination reaction, resulting in the formation of ortho-quinone dimethide (o-QDM) intermediates that further participated in Diels-Alder or hetero-Diels-Alder cycloadditions. The analogous benzylic acetals or ethers, on the other hand, bypassed the C-H insertion pathway and, after hydride transfer, underwent a de-aromatizing elimination reaction to form o-QDM at ambient temperature. The resulting dienes exhibited high diastereo- and regio-selectivity when involved in various cycloaddition reactions. This method represents a rare example of catalytic o-QDM generation without the involvement of a benzocyclobutene, and it offers a mild and ambient temperature approach to access these valuable intermediates. DFT calculations provided support for the proposed mechanism. Furthermore, this methodology was successfully applied to the synthesis of (+/-)-isolariciresinol with an overall yield of 41%.
Article
Chemistry, Organic
Benjamin D. Bergstrom, Garrett Toth-Williams, Anna Lo, Jeffrey W. Toman, James. C. Fettinger, Jared T. Shaw
Summary: Polysubstituted allenes are important synthetic intermediates that offer structural complexity, modularity, and axial chirality in further transformations. We report the synthesis of tetrasubstituted allenes featuring a novel geminal acyl/alkoxy substitution, which exhibit both stability and interesting reactivity in several applications.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Leslie A. Nickerson, Benjamin D. Bergstrom, Mingchun Gao, Yuan-Shin Shiue, Croix J. Laconsay, Matthew R. Culberson, Walker A. Knauss, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw
