Article
Nutrition & Dietetics
Lois Veen, Essi Hantikainen, Rino Bellocco, Weimin Ye, Mauro Serafini, Marta Ponzano, Alessandra Grotta, Ylva Trolle Lagerros
Summary: After a 19-year study involving nearly 44,000 men and women, it was found that dietary intake of vitamin E may be positively associated with the risk of osteoarthritis, while no significant associations were observed between vitamin C, beta-carotene, and NEAC with osteoarthritis risk.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Chemistry, Multidisciplinary
Young Geon Kim, Yunjung Lee, Nohyun Lee, Min Soh, Dokyoon Kim, Taeghwan Hyeon
Summary: The field of nanocatalytic therapy, which employs catalytic reactions mediated by nanomaterials to intervene in disease-critical biomolecular processes, has gained increasing interest in the last 20 years. Ceria nanoparticles have shown unique scavenging properties against biologically noxious free radicals, making them potential candidates for self-regenerating antioxidative and anti-inflammatory agents in disease therapy. This review provides an overview of the characteristics of ceria nanoparticles, their scavenging mechanisms, and recent therapeutic applications, as well as the challenges and future research directions.
ADVANCED MATERIALS
(2023)
Article
Plant Sciences
Mohammad Mukarram, M. Masroor A. Khan, Daniel Kurjak, Alexander Lux, Francisco J. Corpas
Summary: Lemongrass cultivation is threatened by increasing soil salinity, but silicon nanoparticles (SiNPs) can enhance salt tolerance in lemongrass by minimizing oxidative stress and promoting growth and photosynthetic performance. SiNPs also improve enzymatic antioxidant activity and osmolyte accumulation. In addition, SiNPs enhance oil biosynthesis in lemongrass, making them a useful tool to alleviate salinity stress in lemongrass and related crops.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Zafar Iqbal, Ali Sarkhosh, Rashad Mukhtar Balal, Celina Gomez, Muhammad Zubair, Noshin Ilyas, Naeem Khan, Muhammad Adnan Shahid
Summary: Flooding-induced hypoxia stress causes damage to plants by reducing green pigments, gas exchange, and photosynthetic activity, but the application of silicon nanoparticles (SiNPs) can enhance antioxidant activities, osmoprotectant accumulation, and micronutrient regulation to help plants combat hypoxia stress more efficiently.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Rekha Thiruvengadam, Baskar Venkidasamy, Ramkumar Samynathan, Rajakumar Govindasamy, Muthu Thiruvengadam, Jin Hee Kim
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates cellular antioxidant defense. It can be activated by oxidative stress and various factors and modifications. Keap1/Nrf2/ARE signaling is a target for treating diseases. Nanomaterials have unique properties and can be used in various biological applications. This review discusses the combined therapy of nanoparticles and Nrf2 and their significance in diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Cristiano Soares, Pedro Nadais, Bruno Sousa, Edgar Pinto, Isabel M. P. L. V. O. Ferreira, Ruth Pereira, Fernanda Fidalgo
Summary: The foliar application of silicon, either as bulk or nano forms, was found to enhance Solanum lycopersicum L. tolerance to glyphosate by reducing oxidative stress and upregulating antioxidant enzymes. Both sources of silicon showed potential in alleviating glyphosate-induced toxicity, with no significant differences in efficacy observed.
Article
Biochemistry & Molecular Biology
Ruta Sutuliene, Ausra Brazaityte, Stanislaw Malek, Michal Jasik, Giedre Samuoliene
Summary: This study aimed to investigate the impact of boron nanoparticles on the antioxidant system and oxidative stress biomarkers in drought-stressed pea plants. The results showed that spraying with B2O3 nanoparticles at 12.5 ppm effectively stimulated phenol accumulation, antioxidant capacity, and enzyme activity in pea leaves exposed to drought. Furthermore, B2O3 nanoparticles reduced the levels of oxidative stress biomarkers and improved the growth and yield of pea plants affected by drought.
Article
Biochemistry & Molecular Biology
Yuhua Zhu, Ziyan Wang, Shuxuan Yu, Chong Zhao, Baofeng Xu, Rui Liu, Li Xu, Yi Guo
Summary: This study investigated the neuroprotective effects of ginseng fibrous root against oxidative stress in Alzheimer's disease (AD). The results showed that ginseng fibrous root enzymatic hydrolysate exhibited antioxidant activities, protected cells from oxidative damage, and improved the survival rate of Caenorhabditis elegans under oxidative stress.
Article
Biochemistry & Molecular Biology
Jedrzej Baszynski, Piotr Kaminski, Maria Bogdzinska, Slawomir Mroczkowski, Marek Szymanski, Karolina Wasilow, Emilia Stanek, Karolina Holderna-Bona, Sylwia Brodzka, Rafal Bilski, Halyna Tkachenko, Natalia Kurhaluk, Tomasz Stuczynski, Malgorzata Lorek, Alina Wozniak
Summary: The intensification of oxidative stress affects male reproductive potential and enzymatic antioxidative mechanisms. Chemical elements, antioxidants, and genetic polymorphism are interconnected and shape male fertility.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Environmental Sciences
Zaid Ulhassan, Imran Khan, Muzammil Hussain, Ali Raza Khan, Yasir Hamid, Sajad Hussain, Suleyman I. Allakhverdiev, Weijun Zhou
Summary: Nanoparticles have shown efficacy in reducing chromium-induced phytotoxicity and improving plant tolerance. They can achieve this by various mechanisms, including improving photosynthetic machinery, regulating cellular metabolites, and activating antioxidants.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Sathiyamoorthy Padmanaban, Durgasruthi Pully, Antony V. Samrot, Vijayakumar Gosu, Nanthini Sadasivam, In-Kyu Park, Kamalakannan Radhakrishnan, Don-Kyu Kim
Summary: Reactive oxygen species (ROS) play a significant role in various biological systems, acting as both a cause and a consequence in liver-related metabolic disorders such as steatohepatitis. Medications targeting ROS formation and reducing ROS levels have gained interest as a therapeutic approach. Nanotechnology, utilizing nanocomplex systems as efficient nano-antioxidants, offers enhanced antioxidant delivery to the target site and improved accuracy, making it a promising avenue for efficient therapeutic interventions in oxidative stress-related liver disorders.
Article
Chemistry, Analytical
Pankaj Gupta, Vandna K. Gupta, Artur Huseinov, Connor E. Rahm, Kiera Gazica, Noe T. Alvarez
Summary: The study developed a nonenzymatic glucose sensor using copper nanoparticles and carbon nanotubes microelectrode set, demonstrating excellent sensitivity, low detection limit, and resistance to external interference. The sensor was successfully applied for quantifying glucose in physiological samples, showing great potential for commercial nonenzymatic glucose sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Borgohain Anima, Pradip Mondal, Guruswami Gurusubramanian, Vikas Kumar Roy
Summary: Copper nanoparticles (CuNPs) are widely used but can pose a risk to human health, particularly in terms of uterine toxicity. This study found that CuNPs can penetrate the uterus and cause uterine injury in rats. The study also revealed that CuNPs induce apoptosis in uterine cells by affecting the apelin signaling pathway, leading to further uterine damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Agriculture, Dairy & Animal Science
Bianca R. Silva, Jose R. V. Silva
Summary: In vitro follicle growth and oocyte maturation have limitations, namely not all in vitro matured oocytes can develop into viable embryos. Reactive oxygen species (ROS) during in vitro culture contribute to low oocyte quality. Non-enzymatic antioxidants like melatonin and resveratrol increase antioxidant enzymes expression, while N-acetyl-cysteine, cysteamine, nobiletin, and quercetin increase levels of glutathione (GSH) to reduce oocyte oxidative stress. Other antioxidants such as L-ascorbic acid, lycopene, L-carnitine, acteoside, laminarin, phycocyanin, and mogroside V also have protective effects against ROS-induced damage. Understanding their mechanisms of actions is crucial for improving in vitro culture systems.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Environmental Sciences
Luis M. F. Alves, Marco F. L. Lemos, Ariana B. Moutinho, Filipe R. Ceia, Juan Munoz-Arnanz, Begona Jimenez, Henrique Cabral, Sara C. Novais
Summary: Chemical pollution poses a major threat to marine ecosystems, especially to top predators like sharks, which are highly susceptible to exposure and accumulation of contaminants. This study examined the contamination levels, composition, and sources in blue sharks inhabiting the Northeast Atlantic, as well as the potential risk to human consumers. High levels of contaminants were found in most sampled sharks, with over 75% exceeding legal limits for human consumption. Consumption of meat from these sharks could potentially expose consumers to dangerous levels of methylmercury. Moreover, the assessment of single contaminants may underestimate the risk to human health, and the accumulation of contaminants in sharks appears to be influenced by their geographical distribution rather than other factors such as sex, size, or prey trophic level.
ENVIRONMENTAL POLLUTION
(2023)
Editorial Material
Environmental Sciences
Eduardo Alves de Almeida, Afonso Celso Dias Bainy, Lucia Guilhermino
Article
Environmental Sciences
Rosa Freitas, Federica Arrigo, Francesca Coppola, Valentina Meucci, Federica Battaglia, Amadeu M. V. M. Soares, Carlo Pretti, Caterina Faggio
Summary: The present study investigated the influence of temperature on the effects of Sodium Lauryl Sulfate (SLS) in the mussel species Mytilus galloprovincialis. Higher biochemical alterations were observed in SLS-exposed mussels and warming enhanced the impacts. These results highlight the potential harm of SLS pollution to mussels and the importance of considering climate changes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Rita Trabulo, M. Clara P. Amorim, Paulo J. Fonseca, Manuel Vieira, Andre B. Matos, Thibaut Marin-Cudraz, Marco F. L. Lemos, Ariana B. Moutinho, Sara C. Novais, Pedro Pousao-Ferreira, Ana Candeias-Mendes, Ana M. Faria
Summary: The growth of human populations has led to an increase in marine traffic, which poses a threat to marine biodiversity. The impact of shipping noise exposure on fish early life stages is still not well understood.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Susana I. L. Gomes, Bruno Guimaraes, Paolo Gasco, Magda Blosi, Anna L. Costa, Janeck J. Scott-Fordsmand, Monica J. B. Amorim
Summary: Nanoemulsions have been studied as carriers for drug delivery, but there is currently no information on their ecotoxicological effects. This study investigated the toxicity of a nanoemulsion material designed for use as a liposomal excipient for eye drops, and found that it was toxic to soil organisms, affecting survival, reproduction, and size. These findings provide important ecotoxicological data for a group of nanomaterials and suggest the need for formulation improvements to reduce environmental impact.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Susana I. L. Gomes, Sekerani B. Chidiamassamba, Tito Trindade, Janeck J. Scott-Fordsmand, Monica J. B. Amorim
Summary: Nanoagrochemicals have the potential to revolutionize agriculture by reducing application rates and maintaining efficacy. However, the environmental risk assessment of these advanced materials is often lacking. This study evaluated the ecotoxicity of the commercial fertilizer WELGRO & REG; Cu + Zn on soil invertebrates and found that the nano-features of the fertilizer resulted in higher toxicity compared to its individual components.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Joao A. Rodrigues, Daniela S. C. Bispo, Monica G. Silva, Rita Araujo, Amadeu M. V. M. Soares, Rosa Freitas, Ana M. Gil
Summary: This study investigates the effects of exposure to 17-α-ethinylestradiol (EE2) on lipophilic extracts of Ruditapes philippinarum clams at 17 degrees C and 21 degrees C. The results show that EE2 exposure at 17 degrees C leads to a slight increase in membrane rigidity at low concentrations, while at higher concentrations, lipid metabolism stabilizes. In contrast, at 21 degrees C, lipid metabolism responds to EE2 at 125 ng/L, with the antioxidant docosahexaenoic acid (DHA) helping to mitigate oxidative stress. The study also identifies new potential markers of stress mitigation, such as high levels of phosphatidylcholine (PtdCho), polyunsaturated fatty acids (PUFAs), and linoleic acid, as well as low PUFA/glycine ratios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Environmental
Melissa Mariana, Miguel Castelo-Branco, Amadeu M. Soares, Elisa Cairrao
Summary: Phthalates, essential components in the plastics industry, are widely present in the environment and everyday life. They are classified as endocrine-disrupting compounds and are easily absorbed by the human body, interfering with hormonal homeostasis and potentially leading to the development of various diseases in different age groups.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Ana Sofia Quina, Andreia C. M. Rodrigues, Amadeu M. V. M. Soares, Maria da Luz Mathias, Carlos Gravato
Summary: The greater white-toothed shrew Crocidura russula has been used as a sentinel species to assess environmental risks to human populations. Previous studies focused on the liver as the main target of physiological and metabolic changes due to heavy metal pollution, but the shrews still persisted despite liver damage. This study investigates the skeletal muscle tissue of C. russula as an alternative site for detoxification and survival in polluted areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Tiago Morais, Pedro Moleiro, Carla Leite, Francesca Coppola, Joao Pinto, Bruno Henriques, Amadeu M. V. M. Soares, Eduarda Pereira, Rosa Freitas
Summary: This study evaluates the responses of mussels exposed to individual and mixed cobalt, nickel, and mercury and found negative effects on energy reserves, activation of antioxidants and detoxification enzymes, and cellular damage in the mixture.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Diana Campos, Rui G. Morgado, Ana Rita R. Silva, Ana L. Machado, Katerina Grabicova, Vladimir Zlabek, Susana Loureiro, Amadeu M. V. M. Soares, Joao L. T. Pestana
Summary: Personal care products containing organic ultraviolet filters (UV filters) and insect repellents can introduce anthropogenic contaminants into freshwater ecosystems, impacting aquatic organisms. This study evaluated the combined effects of two commonly detected UV filters (Benzophenone-3 (BP3) and Enzacamene (4-MBC)) and BP3 combined with an insect repellent (N,N-diethyl-3-methylbenzamide - DEET) on the life-history traits of Chironomus riparius. The results showed synergistic effects between BP3 and 4-MBC on emergence rate, whereas the effects of BP3 and DEET mixture differed for males and females. The study highlights the complexity of chemical mixtures in sediments and the importance of assessing their combined effects for accurate risk assessment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Susana I. L. Gomes, Sekerani B. Chidiamassamba, Janeck J. Scott-Fordsmand, Monica J. B. Amorim
Summary: Nanopesticides have the potential to increase agricultural productivity in a more sustainable way, but there is limited research on their environmental risk assessment. In this study, the ecotoxicity of the nanopesticide Karate Zeon and its active substance lambda-cyhalothrin were investigated and compared. Results showed no significant difference in toxicity between Karate Zeon and lambda-cyhalothrin, but different stages of development may have varying sensitivity. The use of Karate Zeon can benefit from reduced application rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Rone S. Barbosa, Fabianne Ribeiro, Eliane Aparecida Rotili, Rosaina de Sousa Venega, Aline Silvestre Pereira Dornelas, Amadeu M. V. M. Soares, Carlos Gravato, Renato Almeida Sarmento
Summary: This study evaluated the biological effects of the commercial formulation Actara on the aquatic non-target and non-biting larvae of Chironomus xanthus. The results showed that Actara was non-toxic to C. xanthus at environmentally relevant concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Luis Gabriel A. Barboza, Xose L. Otero, Ezequiel Fernandez, Luis R. Vieira, Jose O. Fernandes, Sara C. Cunha, Lucia Guilhermino
Summary: This pilot study examined the potential link between the presence of microplastics (MPs) in the brain of 180 wild fish and the activity of the acetylcholinesterase (AChE) enzyme. MPs were found in 5% of the samples, all from one species collected in the summer. Seventeen MPs were found in brain samples, with sizes ranging from 8 to 96 μm. Fish with MPs showed significantly lower AChE activity compared to those without MPs. These findings highlight the contribution of MPs to pollution-induced neurotoxicity and emphasize the need for further research in this area for better "One Health" protection.
Article
Chemistry, Multidisciplinary
Fatima C. F. Santos, Rudo A. Verweij, Amadeu M. V. M. Soares, Janeck J. Scott-Fordsmand, Cornelis A. M. van Gestel, Monica J. B. Amorim
Summary: This study assessed the multigenerational effects of silver nanomaterials (Ag NM300K) and silver salt (AgNO3) on soil invertebrates. The results showed that both forms of silver caused a decrease in reproduction, and silver uptake decreased over time. After reaching a certain concentration, detoxification mechanisms seemed to be activated, leading to a decrease in reproductive output. Transfer to clean soil allowed for complete elimination of silver from the animals.
NANOSCALE ADVANCES
(2023)
