Article
Nanoscience & Nanotechnology
Sheng Wang, Hailin Shen, Qiulian Mao, Qing Tao, Guotao Yuan, Lingli Zeng, Ziying Chen, Yunjiao Zhang, Liang Cheng, Jingzhong Zhang, Hui Dai, Chunhong Hu, Yue Pan, Yonggang Li
Summary: A macrophage loaded with a photothermal nanoprobe was developed to cross the blood-brain barrier and accumulate into deep gliomas for multimodal imaging and guided surgery purposes. This nanoplatform shows promise for achieving accurate diagnosis, imaging-guided surgery, and effective photothermal therapy for gliomas.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin Seok Yi, Hee Jong Ki, Yoo Sung Jeon, Jeong Jin Park, Taek-Jun Lee, Jin Tae Kwak, Sang Bong Lee, Hyung Jin Lee, In Seong Kim, Joo Hyun Kim, Ji Sung Lee, Hong Gee Roh, Hyun Jeong Kim
Summary: This study evaluated the ability of collateral maps to predict lesion growth and penumbra after acute anterior circulation ischemic strokes. The results showed that collateral perfusion grades were associated with lesion growth, and the collateral ratio had a high concordance correlation coefficient, making it useful for personalized application of recanalization treatments.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Philipp Vollmuth, Martha Foltyn-Dumitru, Felix Sahm, Kyu Sung Choi, Ji Eun Park, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim
Summary: The fifth edition of the World Health Organization classification of central nervous system tumors published in 2021 focuses on the transitional state between traditional histopathology-based classification and molecular diagnostics. This review emphasizes the molecular diagnostics and imaging findings of glioneuronal and neuronal tumors, which often overlap with pediatric-type gliomas and circumscribed astrocytic gliomas. Due to this overlap, radiologists play a crucial role in utilizing imaging features to differentiate difficult cases with inconclusive histopathology and genetic alterations.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Oncology
Malik Galijasevic, Ruth Steiger, Stephanie Mangesius, Julian Mangesius, Johannes Kerschbaumer, Christian Franz Freyschlag, Nadja Gruber, Tanja Janjic, Elke Ruth Gizewski, Astrid Ellen Grams
Summary: This review provides an insight into the use of magnetic resonance spectroscopy (MRS) in the diagnosis and follow-up of gliomas. It covers both proton and phosphorous MRS techniques in clinical and scientific practice, including preoperative grade prediction and post-treatment follow-up. The review also discusses the current research utility and possible future strategies of proton and phosphorous MRS in glioma research.
Article
Neurosciences
Pauline Mouches, Matthias Wilms, Deepthi Rajashekar, Sonke Langner, Nils D. Forkert
Summary: This study aimed to develop deep learning models to predict biological brain age using multimodal imaging data. The results showed that combining T1-weighted and angiography MRI data significantly improved prediction accuracy, while also identifying the most contributing brain regions and arteries.
HUMAN BRAIN MAPPING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Philipp Vollmuth, Martha Foltyn-Dumitru, Felix Sahm, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim
Summary: The fifth edition of the 2021 WHO classification of central nervous system tumors highlights the importance of molecular diagnostics and genetic alterations in the classification of gliomas. Molecular biomarkers now play a role in establishing tumor grades and providing prognostic information. Radiologists need to understand the changes in the classification for accurate imaging interpretation and communication with clinicians. This review series focuses on the implications of the 2021 WHO classification on imaging diagnosis for gliomas and other related tumors.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neuroimaging
Bikei Ryu, Shinsuke Sato, Masayuki Takase, Tatsuki Mochizuki, Shogo Shima, Tatsuya Inoue, Yoshikazu Okada, Yasunari Niimi
Summary: This study investigated the use of 3D-RA/3D-MR fusion images for diagnosing SAVS, showing higher interobserver agreement and better image quality compared to 3D-RA images. The fusion images allowed for detailed evaluation of the anatomical structures surrounding the shunt.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai, Jinhao Gao, Hongyu Lin
Summary: This study reports a new strategy to improve the performance of nanoparticle-based T1 contrast agents by utilizing the photoinduced super-hydrophilic assistance (PISA) effect. By doping gadolinium into citrate-coated titanium dioxide ellipsoidal nanoparticles (GdTi-SC NPs), the r1 value of the nanoparticles significantly increases upon UV irradiation. The existence of the PISA effect is confirmed by the reduced water contact angle and increased surface hydroxyl groups, leading to enhanced paramagnetic relaxation enhancement (PRE) efficiency and improved imaging performance. In vivo MRI experiments on rats demonstrate that GdTi-SC NPs can serve as a high-performance contrast agent for sensitive imaging of blood vessels and accurate diagnosis of vascular lesions, indicating the success of the proposed strategy.
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongxi Zhang, Xingwang Yong, Xiaohui Ma, Jianjiang Zhao, Zhipeng Shen, Xinchun Chen, Fengyu Tian, Weibo Chen, Dan Wu, Yi Zhang
Summary: APT imaging can differentiate high-grade and low-grade gliomas in pediatric patients, and provides additional value beyond quantitative relaxation times.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Philipp Vollmuth, Martha Foltyn-Dumitru, Felix Sahm, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim
Summary: The fifth edition of the WHO classification of central nervous system tumors published in 2021 advances the role of molecular diagnostics in glioma classification. This review focuses on the molecular diagnostics and imaging findings of pediatric-type diffuse high-grade gliomas, pediatric-type diffuse low-grade gliomas, and circumscribed astrocytic gliomas. Understanding molecular diagnostics and imaging findings is crucial for radiologists in clinical practice.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Henrik Leonhardt, Anne Thilander-Klang, John Bath, Marit Johannesson, Niclas Kvarnstrom, Pernilla Dahm-Kahler, Mats Brannstrom
Summary: The study compared CT angiography (CTA), digital subtraction angiography (DSA), and MR angiography (MRA) in evaluating uterine arteries (UA) of potential living donors for uterus transplantation (UTx). MRA was found to be unable to fully evaluate some UAs, with lower radiation doses in DSA.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angela Bernabeu-Sanz, Maria Fuentes-Baile, Cristina Alenda
Summary: The study found that IDH1-wt tumors are more necrotic than IDH1-mut tumors, and that the infiltrative pattern in HGG is associated with loss of p53 expression, Ki-67 index, and Glx levels. Additionally, tumor choline levels could be used as a predictive factor in survival, in addition to IDH1 status, to provide a more accurate prediction of survival in HGG patients.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang
Summary: Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd-DTPA), have limited blood circulation time due to rapid clearance by the kidney, which hinders the improvement of contrast between tumors and normal tissue. To address this issue, a novel MRI contrast agent using deformable mesoporous organosilica nanoparticles (D-MON) incorporating Gd-DTPA is fabricated. In vivo distribution studies show that the D-MON-based contrast agent can prolong blood circulation time and achieve high-contrast imaging in tumor tissue, surpassing the performance of the clinical contrast agent Gd-DTPA.
ADVANCED MATERIALS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie Thust, Caroline Micallef, Sachi Okuchi, Sebastian Brandner, Atul Kumar, Kshitij Mankad, Stephen Wastling, Laura Mancini, Hans Rolf Jaeger, Ananth Shankar
Summary: H3 K27M-mutant diffuse midline gliomas in teenagers and adults exhibit heterogeneous signal, contact with midline, and invasive features. Diffusion-weighted MRI demonstrates commonly low ADC values in the solid tumor portion.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Multidisciplinary Sciences
Xiaoxia Song, Zhi Chen, Xue Zhang, Junfeng Xiong, Teng Jiang, Zihan Wang, Xinran Geng, U. Kei Cheang
Summary: Magnetic tri-bead microrobots with NIR photothermal response drug delivery mechanisms showed excellent potential for targeted chemo-photothermal therapy for lung cancer cells, demonstrating precise targeting and effective treatment.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Li Chen, Zhi-xing Liu, Qiu-chen Bi, Jun Zhao, Qing-rong Liang, Qun Tang
Summary: The study showed that incremental increases in paclitaxel dosage following ultrasound-guided percutaneous ethanol-paclitaxel combined therapy in a rabbit liver cancer model resulted in greater tumor necrosis, indicating a significant anti-proliferative effect.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Pharmacology & Pharmacy
Yang-Feng Lv, Zhi-Qiang Deng, Qiu-Chen Bi, Jian-Jun Tang, Hong Chen, Chuan-Sheng Xie, Qing-Rong Liang, Yu-Hua Xu, Rong-Guang Luo, Qun Tang
Summary: This study proposes a new method for treating hepatocellular carcinoma (HCC) using transarterial chemoembolization (TACE), called DOX-TASE. By modulating the chemo-environment with sevelamer, a polymeric phosphate binder, intratumoral inorganic phosphate (Pi) starvation is induced, resulting in increased accumulation and retention of the chemotherapy drug doxorubicin (DOX) in the tumor. This new approach induces more severe tumor necrosis compared to conventional TACE and drug-eluting bead TACE.
Article
Pharmacology & Pharmacy
Qiu-Chen Bi, Jian-Jun Tang, Jun Zhao, Yang-Feng Lv, Zhi-Qiang Deng, Hong Chen, Yu-Hua Xu, Chuan-Sheng Xie, Qing-Rong Liang, Rong-Guang Luo, Qun Tang
Summary: Sevelamer arsenite nanoparticle is a promising drug delivery system for the treatment of solid tumors. Its unique Pi-responsive properties enable enhanced tumor necrosis compared to arsenic trioxide, and in-vitro tests have shown that it can enhance the anticancer effect of arsenic trioxide.
Article
Nanoscience & Nanotechnology
Qiu-Chen Bi, Yan-Shu Li, Rong-Guang Luo, Hong Chen, Yang-Feng Lv, Zhi-Xing Liu, Qing-Rong Liang, Li Chen, Bao-Hua Xu, Qun Tang
Summary: Decades of research have led to rapid progress in the development of polymeric embolic materials for vascular applications. This study proposes a new concept of 'responsive embolization' using ground sevelamer nanoparticles, which can effectively occlude blood flow in vessels when exposed to inorganic phosphate. Additionally, citrated sevelamer nanoparticles demonstrate delayed aggregation and deeper penetration into the capillary system, making them a potential new type of vascular embolic.
Article
Chemistry, Analytical
Junfeng Xiong, Xiaoxia Song, Yuhang Cai, Jiahe Liu, Yangyuan Li, Yaqiang Ji, Liang Guo, U. Kei Cheang
Summary: The small size of robotic microswimmers makes them ideal for biomedical tasks in tiny, enclosed spaces. However, the degradability of these microswimmers is a pressing concern. In this study, a new method for preparing degradable hydrogel achiral crescent microswimmers was proposed. The microswimmers showed good biocompatibility and were able to achieve swimming efficiency comparable to previous microswimmers. This research demonstrates the potential of degradable hydrogel microswimmers for microscale applications.
Article
Nanoscience & Nanotechnology
Xiaoxia Song, Rongxin Qian, Tingting Li, Wei Fu, Lijun Fang, Yuzhen Cai, Heng Guo, Lei Xi, U. Kei Cheang
Summary: Researchers have developed a macrophage membrane-coated nanocomplex that can target and modulate the immune system for tumor therapy. The nanocomplex utilizes photoacoustic imaging and magnetic guidance, resulting in synergistic therapeutic effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Haoying Wang, Xiaoxia Song, Junfeng Xiong, U. Kei Cheang
Summary: In this study, bilayer magnetic microrobots with an achiral planar design were fabricated using a biocompatible natural polymer and Fe3O4 nanoparticles. These microrobots demonstrated excellent cell biocompatibility and high mobility, providing a solution for biomedical applications.
Article
Biotechnology & Applied Microbiology
Hong Chen, Chuan-Sheng Xie, Yan-Shu Li, Zhi-Qiang Deng, Yang-Feng Lv, Qiu-Chen Bi, Jian-Jun Tang, Rong-Guang Luo, Qun Tang
Summary: This study investigated the safety and therapeutic efficiency of transarterial sevelamer embolization (TASE) and found that sevelamer ultrafine particles are a safe and efficient embolic agent for the treatment of liver cancer, which can replace the current microsphere-based embolization techniques.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Zhi Chen, Xiaoxia Song, Xueliang Mu, Junkai Zhang, U. Kei Cheang
Summary: Cell delivery using magnetic microswimmers is a promising tool for targeted therapy. This study presents the fabrication of rapid and uniform manufactur-able 2D magnetic achiral microswimmers with pores for delivering bone marrow mesenchymal stem cells (BMSCs) to regenerate articular-damaged cartilage. The microswimmers exhibit rolling or swimming motions under magnetic fields and demonstrate biocompatibility and long-distance targeting capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Qun Tang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qiu-Chen Bi, Zhi-Qiang Deng, Yang-Feng Lv, Yue Liu, Chuan-Sheng Xie, Yuan-qiao He, Qun Tang
Summary: This study found that low Pi stress can enhance the sensitivity of hepatocellular carcinoma to sorafenib by suppressing the migration and invasion of cancer cells and inhibiting angiogenesis. Low Pi stress also decreased the viability of sorafenib-resistant cells by directly regulating the expression of specific proteins. In vivo analysis confirmed the enhanced sensitivity of hepatocellular carcinoma to sorafenib under low Pi stress. Overall, low Pi stress can improve the efficacy of sorafenib in treating hepatocellular carcinoma and expand the indications for sevelamer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Yang-feng Lv, Zi-qiang Liao, Qiu-chen Bi, Chuan-sheng Xie, Xiao-yong Wei, Yi Yun, Yuan-qiao He, Qun Tang
Summary: Numerous studies have shown the positive correlation between high levels of Pi and tumor progression. This study aimed to investigate the relationship between macrophage polarization and low-Pi stress. The results revealed that low-Pi stress can repolarize tumor-associated macrophages (TAMs) towards the M1 phenotype, inhibiting tumor growth and activating the immune response.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
David Quashie, Prateek Benhal, Zhi Chen, Zihan Wang, Xueliang Mu, Xiaoxia Song, Teng Jiang, Yukun Zhong, U. Kei Cheang, Jamel Ali
Summary: In the past two decades, there has been an increasing amount of research on wireless devices that can operate at the scale of biological cells or even smaller. One prominent type of these devices is bio-hybrid actuators, which integrate biological cells or subcellular components with synthetic or inorganic parts. Magnetic bio-hybrid actuators have recently shown promise in addressing challenges in small scale fabrication, control, and localization. They also have the potential for high efficiency, self-repair, and self-replication. By combining these properties with magnetically driven forces and torques, which can be controlled and are biologically safe, magnetic bio-hybrid actuators have significant advantages over other small scale actuators.
Article
Pharmacology & Pharmacy
Qiu-Chen Bi, Rong-Guang Luo, Yan-Shu Li, Jun Zhao, Xin Fu, Hong Chen, Yang-Feng Lv, Zhi-Xing Liu, Qing-Rong Liang, Qun Tang
Summary: Metabolic stress and inorganic phosphate burden are known stimulators of cancer progression. The introduction of transarterial sevelamer embolization (TASE) as an alternative to conventional chemoembolization has shown promising results in reducing metastasis and recurrence in liver cancer models. The technique depletes intratumoral inorganic phosphate and inhibits tumor vascularity and metastasis by downregulating angiogenic factors and oncoprotein expression.
ADVANCED THERAPEUTICS
(2022)