Review
Engineering, Biomedical
Leanne de Silva, Paulina N. Bernal, A. J. W. Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Summary: The development of tissue engineering strategies for treatment of large bone defects is crucial, and creating a vascular network is vital for tissue engineered bone constructs.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Angus Weekes, Nicole Bartnikowski, Nigel Pinto, Jason Jenkins, Christoph Meinert, Travis J. Klein
Summary: Current clinical treatment strategies for small diameter blood vessel bypassing in cardiovascular disease management often fail due to lack of suitable grafts and various complications. The rapid advancement of 3D printing and regenerative medicine technologies has the potential to revolutionize cardiovascular disease management by enabling the production of biological vascular grafts with integration, remodeling, and repair capabilities.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Madison Jade Ainsworth, Nino Chirico, Mylene de Ruijter, Andrei Hrynevich, Inge Dokter, Joost P. G. Sluijter, Jos Malda, Alain van Mil, Miguel Castilho
Summary: In order to develop thick engineered cardiac tissue construct with a pre-vascularization pathway, a combination of extrusion-based bioprinting and melt electrowriting techniques was investigated. Gelatin methacryloyl (GelMA) was used as a base hydrogel and collagen, Matrigel, and fibrinogen were utilized as interpenetrating polymers to support myocardial functionality. An anatomically inspired vascular pathway was implemented in a dual extrusion-based bioprinting setup. The optimized bioinks effectively filled the microfiber mesh and maintained cell viability, and distinct cell populations were visualized in their respective patterns up to D14.
Review
Chemistry, Multidisciplinary
Gaston A. Primo, Alvaro Mata
Summary: Biological structures are complex and contain structural hierarchy, chemical anisotropy, and compositional heterogeneity, which play a key role in the functionality of living systems. Recently, there has been increasing interest in using different technologies to recreate spatial arrangements of functional molecules in 3D, particularly in tissue engineering.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Multidisciplinary
Diana S. Lim, John D. Jackson, Anthony Atala, James J. Yoo
Summary: There is a pressing need for new treatments for renal failure, but current therapies are limited by the scarcity of viable organs and infrastructure. Kidney tissue engineering holds promise in addressing the shortcomings, but faces challenges, particularly in establishing successful vascularization of engineered tissue constructs.
Review
Chemistry, Multidisciplinary
Ao Sun, Xinye He, Xiao Ji, Danrong Hu, Meng Pan, Linghong Zhang, Zhiyong Qian
Summary: Photopolymerized hydrogels, with their special formation, can effectively control the formation of hydrogels and are widely used in tissue engineering due to their mild conditions and biocompatibility. They can be applied in cell encapsulation, scaffold materials, and other tissue engineering fields with advanced manufacturing methods.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Malin Becker, Melvin Gurian, Maik Schot, Jeroen Leijten
Summary: Embedded 3D bioprinting using low-viscosity ink 3D (LoV3D) bioprinting based on aqueous two-phase stabilization allows for the fabrication of living constructs at high speeds with high viability. The liquid/liquid interfaces of LoV3D bioprinting offer unique advantages for fusing structures, creating vasculature, and modifying surfaces. The low interfacial tension of LoV3D bioprinting allows for nozzle-independent control over filament diameter, enabling the printing of a wide range of diameters down to the width of a single cell.
Article
Biotechnology & Applied Microbiology
Jessica Nulty, Ross Burdis, Daniel J. Kelly
Summary: Bone tissue engineering has potential to revolutionize treatment of challenging musculoskeletal pathologies. Developing tissue-engineered constructs mimicking early stages of tissue development can address issues of poor vascularization in traditional strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Alperen Abaci, Gulden Camci-Unal, Murat Guvendiren
Summary: Three-dimensional (3D) bioprinting is an emerging technology that can fabricate functional tissues and organs, replicating native tissue function. With its precise positioning of cellular materials and utilization of medical images, 3D bioprinting has enormous potential in biomedical applications, such as tissue engineering and regenerative medicine. It is a rapidly progressing field that has shown clinically relevant uses.
Article
Biophysics
Chuang Gao, Chunxiang Lu, Zhian Jian, Tingrui Zhang, Zhongjian Chen, Quangang Zhu, Zongguang Tai, Yuanyuan Liu
Summary: The skin, as the first line of defense, is susceptible to damage and there is a growing demand for artificial skin in various fields. Traditional skin tissue engineering has made progress, but there are challenges and prospects in 3D bioprinting.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Naresh Mahajan, James J. Yoo, Anthony Atala
Summary: Three-dimensional bioprinting technology has experienced rapid development in the field of biofabrication, leading to the successful generation of functional tissues. However, there are still numerous scientific challenges that need to be addressed, requiring the convergence of expertise from multiple disciplines.
Review
Materials Science, Multidisciplinary
Shivesh Anand, Serena Danti, Lorenzo Moroni, Carlos Mota
Summary: It is estimated that by 2050 one in every ten people will be suffering from disabling hearing loss. Perforated tympanic membranes (TMs) are the most common injury to the human ear, resulting in a partial or complete hearing loss due to inept sound conduction. Tissue engineering approaches, including TM repair and reconstruction, have been developed for TM regeneration.
PROGRESS IN MATERIALS SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Martina M. De Santis, Hani N. Alsafadi, Sinem Tas, Deniz A. Bolukbas, Sujeethkumar Prithiviraj, Iran A. N. Da Silva, Margareta Mittendorfer, Chiharu Ota, John Stegmayr, Fatima Daoud, Melanie Koenigshoff, Karl Sward, Jeffery A. Wood, Manlio Tassieri, Paul E. Bourgine, Sandra Lindstedt, Sofie Mohlin, Darcy E. Wagner
Summary: The study introduces a hybrid bioink composed of alginate and rECM for 3D bioprinting, showing promising printing properties and biological inductive capabilities for generating human tissue.
ADVANCED MATERIALS
(2021)
Review
Polymer Science
Mattia Bartoli, Erik Piatti, Alberto Tagliaferro
Summary: The development of new scaffolds and materials for tissue engineering is a wide and open realm of material science. Among solutions, the use of biopolymers represents a particularly interesting area of study due to their great chemical complexity that enables creation of specific molecular architectures. However, biopolymers do not exhibit the properties required for direct application in tissue repair-such as mechanical and electrical properties-but they do show very attractive chemical functionalities which are difficult to produce through in vitro synthesis. The combination of biopolymers with nanostructured carbon fillers could represent a robust solution to enhance composite properties, producing composites with new and unique features, particularly relating to electronic conduction. In this paper, we provide a review of the field of carbonaceous nanostructure-containing biopolymer composites, limiting our investigation to tissue-engineering applications, and providing a complete overview of the recent and most outstanding achievements.
Article
Materials Science, Biomaterials
Yahui Zhang, Yin Yu, Adil Akkouch, Amer Dababneh, Farzaneh Dolati, Ibrahim T. Ozbolat
BIOMATERIALS SCIENCE
(2015)
Article
Biophysics
Yin Yu, Yahui Zhang, James A. Martin, Ibrahim T. Ozbolat
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2013)
Article
Engineering, Manufacturing
Yin Yu, Yahui Zhang, Ibrahim T. Ozbolat
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2014)
Article
Materials Science, Biomaterials
Yahui Zhang, Yin Yu, Farzaneh Dolati, Ibrahim T. Ozbolat
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2014)
Article
Engineering, Biomedical
Yahui Zhang, Yin Yu, Howard Chen, Ibrahim T. Ozbolat