Article
Biotechnology & Applied Microbiology
Bing Chen, Kaifan Zheng, Shubin Fang, Kangping Huang, Chengchao Chu, Junyang Zhuang, Jin Lin, Shaoguang Li, Hong Yao, Ailin Liu, Gang Liu, Jizhen Lin, Xinhua Lin
Summary: This study introduces a dual-compartment targeted B7H3 multifunctional gold conjugate system that can control the exposure of Dox in a spatio-temporal manner without evident toxicity. It suggests a general strategy for synergistic therapy against NSCLC.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biophysics
David Limon, Silvia Vila, Anahi Herrera-Olivas, Rodrigo Vera, Josefa Badia, Laura Baldoma, Marta Planas, Lidia Feliu, Lluisa Perez-Garcia
Summary: Conjugation of cytostatic drugs to nanomaterials aims to improve their bioavailability and selectivity. Water-soluble gold nanoparticles were synthesized as transporters for synthetic cyclic peptides, showing stability and higher toxicity towards cancer cells with improved uptake.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Omer Akturk
Summary: Increasing the amount of levan enhances the colloidal stability and drug encapsulation efficiency of the nanoparticle complexes, and complexes with higher DOX loadings show significant anticancer effects on MCF-7 breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Xinxin Cui, Kunda Du, Xiaoyin Yuan, Wen Xiao, Yayu Tao, Defeng Xu, Hang Hu
Summary: Five Man-DOX conjugates with different linkers were developed and characterized in this study. Among them, Man-DG-DOX showed the highest cellular uptake amount and the best in vitro antitumor effect on HepG2 cells, indicating its potential for selective DOX delivery to mannose receptor overexpressed tumors.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Sajini D. Hettiarachchi, Emel Kirbas Cilingir, Heidi Maklouf, Elif S. Seven, Suraj Paudyal, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: This study compared three different covalent carbon dots systems for doxorubicin release and cancer cell viability under acidic and physiological conditions. Results indicated that the pH stimuli C-dots-HBA-dox system showed the highest efficacy in doxorubicin release in acidic pH, while the redox stimuli C-dots-S-S-dox system performed well in physiological conditions.
Article
Pharmacology & Pharmacy
Sante Di Gioia, Adriana Trapani, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Saverio Cellamare, Isabella Bolognino, Md Niamat Hossain, Enrico Sanna, Giuseppe Trapani, Massimo Conese
Summary: The synthesis and characterization of a novel N,O-CMCS-Dopamine (DA) amide conjugate was reported, showing its potential utility for Parkinson's disease treatment compared to an analogous N,O-CMCS-DA ester conjugate. The amide conjugate played an important role in preventing DA spontaneous autoxidation, and demonstrated cyto-compatibility with Olfactory Ensheating Cells (OECs) for efficient internalization. Overall, the N,O-CMCS-DA amide conjugate appears to be a promising candidate for improving DA delivery via nose-to-brain administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Plant Sciences
Monica Surek, Mariana M. Fachi, Alexandre de Fatima Cobre, Favizia F. de Oliveira, Roberto Pontarolo, Amanda R. Crisma, Wesley M. de Souza, Karina B. Felipe
Summary: Propolis extracts exhibit antitumor, antibacterial properties and can be a potential source of antineoplastics and antibiotics. They show selective cytotoxicity against tumor cells and synergistic effects in combination with doxorubicin and gentamicin. The natural products may help reduce adverse effects and resistance associated with doxorubicin and gentamicin.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amal A. Sultan, Ghada A. Saad, Gamal M. El Maghraby
Summary: This study investigated the use of bilosomes encapsulating absorption enhancers as carriers for enhancing the oral absorption and cytotoxicity of doxorubicin. The bilosomes were found to significantly improve the intestinal absorption and cytotoxicity of doxorubicin against breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yang Yu, Teng Wang, Xin Meng, Tianze Jiang, Xia Zhao
Summary: To overcome the limitations of DNA damage repair in tumor cells and the damaging effect of high temperatures induced by photothermal therapy (PTT) on adjacent normal tissues, a novel composite hydrogel (OLA-Au-Gel) was developed. OLA-Au-Gel achieved mild PTT (mPTT) through CS-AuNPs and inhibited tumor DNA damage repair through OLA. The hydrogel showed good biocompatibility, injectability, and photothermal response, effectively inhibiting tumor growth both in vitro and in vivo. OLA-Au-Gel holds promising application prospects for tumor inhibition and enhancing the antitumor effect.
Article
Biochemical Research Methods
Stepan Chuprakov, Ayodele O. Ogunkoya, Robyn M. Barfield, Maxine Bauzon, Colin Hickle, Yun Cheol Kim, Dominick Yeo, Fangjiu Zhang, David Rabuka, Penelope M. Drake
Summary: This study addresses critical limitations in current ADC technology by developing a tandem-cleavage linker strategy, which significantly improves stability, efficacy, and tolerability of ADCs. By enhancing linker stability, the research demonstrates the potential to improve an ADC's therapeutic index for better patient outcomes.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Harsha Icharam Narkhede, Avinash Shridhar Dhake, Ajaykumar Rikhabchand Surana
Summary: The novel TSC-DTCs hybrids show promising pharmacological applications with higher activity than their precursor compounds. Some of these hybrids exhibit excellent antioxidant and anticancer properties.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Dhanya Rajan, Ramar Rajamanikandan, Malaichamy Ilanchelian
Summary: The current study investigates the photophysical interactions between xanthene dyes and CTAB-AuNRs. Significant modifications in the optical spectroscopic characteristics of the dyes were observed when they are conjugated with CTAB-AuNRs. Extinction spectral results indicate strong electrostatic interactions and ground state complex between the dyes and CTAB-AuNRs, which lead to the emission quenching of the dyes. The computational interaction analyses also support the near closeness of the dye molecules and CTAB-AuNRs. Additionally, the cytotoxicity study shows that the dye-nanoconjugates exhibit higher toxicity against cancer cells compared to the free dyes.
Article
Chemistry, Multidisciplinary
Mariana Zavarize, Nikolai V. V. Sibirev, Yury Berdnikov, Murilo Moreira, Helio T. Obata, Varlei Rodrigues, Vladimir G. G. Dubrovskii, Monica A. Cotta
Summary: InP nanowires were catalyzed by Au, Ag, and Au-Ag nanoparticles on GaAs substrates with different orientations. Statistical analysis and modeling demonstrated that the ratio of droplet surface density to In precursor flux is critical in controlling nanowire growth mode and orientation. These findings enhance our understanding of planar nanowire vapor-liquid-solid growth and provide tools for controlling III-V nanowire growth on lattice-mismatched substrates.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Polymer Science
Maria Psarrou, Martha Georgia Kothri, Maria Vamvakaki
Summary: A new linear copolymer based on acylhydrazone linkages was synthesized and characterized for its degradation under both acidic and photo conditions. The copolymer was chemically linked to an anticancer drug to form amphiphilic polymer-drug conjugates, which self-assembled into spherical nanoparticles for therapeutic cargo release. The assemblies were disrupted under UV light and decreased pH, releasing the drug payload.
Article
Biochemistry & Molecular Biology
Jayne Torres de Sousa, Rafael Rodrigues Dihl, Fernanda Briao Menezes Boaretto, Ana Leticia Hilario Garcia, Ivana Grivicich, Juliana da Silva, Jaqueline Nascimento Picada
Summary: This study evaluated the cytotoxic and mutagenic effects of morphine alone and in combination with doxorubicin. Morphine showed cytotoxic effects on neuroblastoma cells and reduced the cytotoxic effects of doxorubicin. Morphine did not induce mutations and decreased the mutagenic effects induced by doxorubicin in certain strains.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Astronomy & Astrophysics
Jay Nadeau, Chris Lindensmith, Jody W. Deming, Vicente I. Fernandez, Roman Stocker
Article
Optics
Eugene Serabyn, Kurt Liewer, Chris Lindensmith, Kent Wallace, Jay Nadeau
Article
Chemistry, Multidisciplinary
Jay L. Nadeau, Yong Bin Cho, Jonas Kuhn, Kurt Liewer
FRONTIERS IN CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Manuel Bedrossian, Casey Barr, Chris A. Lindensmith, Kenneth Nealson, Jay L. Nadeau
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Editorial Material
Biochemical Research Methods
Jay Nadeau, YongKeun Park, Gabriel Popescu
Article
Biochemical Research Methods
Zach Marin, J. Kent Wallace, Jay Nadeau, Andre Khalil
Article
Biology
Konstantin A. Kudinov, Daniel R. Cooper, Jonathan K. Ha, Colin K. Hill, Jay L. Nadeau, Jan P. Seuntjens, Stephen E. Bradforth
RADIATION RESEARCH
(2018)
Article
Biology
Iufia Hancziuek, Aaron J. Kenna, Chris Lindensmith, Jay Nadeau
RADIATION RESEARCH
(2018)
Article
Optics
Manuel Bedrossian, J. Kent Wallace, Eugene Serabyn, Christian Lindensmith, Jay Nadeau
Article
Chemistry, Multidisciplinary
Yekaterina G. Chmykh, Jay L. Nadeau
Article
Optics
True Gibson, Manuel Bedrossian, Eugen Serabyn, Chris Lindensmith, Jay L. Nadeau
Summary: The Gouy phase anomaly is described as an additional pi phase shift that accumulates as a wave passes through focus. In this study, it is demonstrated that the anomaly can be directly detected in the phase image using the z-derivative of the phase, allowing for precise localization of unlabeled, micrometer-sized bacteria. The approach is less computationally intensive and relatively insensitive to reconstruction parameters compared to other procedures like deconvolution.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
(2021)
Review
Multidisciplinary Sciences
Jacqueline M. Acres, Myka Jaap Youngapelian, Jay Nadeau
Summary: As interest in space exploration grows, there is an increasing need to understand the impact of microgravity on microbial behavior, particularly motility. Studies on the effects of microgravity on microbial motility are limited, but genomic and transcriptomic research provide insights into the potential effects. A focus on specific strains of Gram-negative bacteria is common in this research.
Article
Chemistry, Multidisciplinary
Arash Farhadi, Manuel Bedrossian, Justin Lee, Gabrielle H. Ho, Mikhail G. Shapiro, Jay L. Nadeau
Article
Astronomy & Astrophysics
Manuel Bedrossian, Chris Lindensmith, Jay L. Nadeau
Article
Chemistry, Analytical
Hala Ghali, Hicham Chibli, Jay L. Nadeau, Pablo Bianucci, Yves-Alain Peter