期刊
NANOTECHNOLOGY
卷 22, 期 27, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/22/27/275312
关键词
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资金
- Core Research for Evolutional Science and Technology
- Japan Science and Technology Agency
- International Human Frontier Science Program
- Grants-in-Aid for Scientific Research [23651112] Funding Source: KAKEN
Novel assemblies of DNA-functionalized gold nanoparticles (DNA-GNPs) have received considerable interest due to their fascinating properties which are desired for various detection applications. In this study, we present innovative GNP assemblies which have a cage-shaped protein ferritin in the center, and discrete GNPs sterically surrounding the central ferritin. These assemblies were constructed by hybridizing DNA-GNP to chemically DNA-modified ferritin, which has a hollow cavity or an iron NP core. Subsequent gel electrophoresis purification and transmission electron microscopy observation showed that ferritin/DNA/GNP assemblies were successfully constructed and can be isolated as independent functional units, which can be used to investigate not only the interaction between the GNPs of complicated GNP clusters but also the interaction between the GNPs and the internalized NP.
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